Search results for "CEC"
showing 10 items of 347 documents
Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor.
2001
Abstract Background/Aims : Cultured human hepatocytes are considered a close model to human liver. However, the fact that hepatocytes are placed in a microenvironment that differs from that of the cell in the liver raises the question: to what extent does drug metabolism in vitro reflect that of the liver in vivo? This issue was examined by investigating the in vitro and in vivo metabolism of aceclofenac, an analgesic/anti-inflammatory drug. Methods : Hepatocytes isolated from programmed liver biopsies were incubated with aceclofenac, and the metabolites formed were investigated by HPLC. During the course of clinical recovery, patients were given the drug, and the metabolites, largely prese…
Sealing ability of five different retrograde filling materials.
1996
The sealing ability of Amalgam, Harvard-Cement, Diaket, gold-leaf, and Ketac-Endo as retrofilling materials was investigated. Paper cones were fixed with Harvard-Cement in the instrumented roots of 100 extracted human incisors. Apicectomy was performed and a 2-mm-deep retrograde cavity was prepared. Teeth were assigned to five groups (n = 20); each group received a different filling material. Surfaces of the roots were isolated with nail polish. Teeth, were stored in 1% methylene blue dye for 72 h. Roots were sectioned, and the depth of dye penetration was evaluated through a stereomicroscope. Retrofills with Ketac-Endo showed significantly less leakage compared with amalgam. There was no s…
Parental working time patterns and children's socioemotional wellbeing: Comparing working parents in Finland, the United Kingdom, and the Netherlands
2017
Abstract This cross-national study examined the connections between parental working time patterns (i.e., regular day work vs. nonstandard working hours) and children's socio-emotional wellbeing defined in terms of internalizing and externalizing problems and prosocial behavior. We also examined how the total number of hours worked, changes in work schedules, working overtime at short notice, and having an influence over one's work schedules were linked with children's wellbeing. Data were collected by a web survey from Finnish ( n = 358), Dutch ( n = 200) and British ( n = 267) parents with children aged 3 to 12 years. The results showed, that in all three countries parents working nons…
South Pole glacial climate reconstruction from multi-borehole laser particulate stratigraphy
2013
AbstractThe IceCube Neutrino Observatory and its prototype, AMANDA, were built in South Pole ice, using powerful hot-water drills to cleanly bore>100 holes to depths up to 2500 m. The construction of these particle physics detectors provided a unique opportunity to examine the deep ice sheet using a variety of novel techniques. We made high-resolution particulate profiles with a laser dust logger in eight of the boreholes during detector commissioning between 2004 and 2010. The South Pole laser logs are among the most clearly resolved measurements of Antarctic dust strata during the last glacial period and can be used to reconstruct paleoclimate records in exceptional detail. Here we use…
Early diagnosis of primary melanoma of caecum. Case report and review of the literature.
2021
Malignant gastrointestinal melanoma is usually a metastatic lesion. We report the case of a 79-year-old female asymptomatic patient. Colonoscopy revealed one plane 15 mm pigmented lesion in the caecum. Neither CT scan of the abdomen nor right hemicolectomy revealed no metastatic disease. Histopathological examination of the surgical specimen was indicative of malignant melanoma.A set of additional enquires such as laboratory and imaging tests did not point out any suspicious lesions in the skin, eye, leptomeninges or other sites. Therefore, we made the diagnosis of primary colonic melanoma.The diagnosis of this disease is still a challange and often demanding for a multidisciplinary approac…
Intertextual Voices of Children, Parents, and Specialists in Individual Education Plans
2019
Planning support and education services requires multifaceted information from professionals, parents, and children. Despite this, educators have emphasized professional opinions in individual education plans (IEPs), whereas the perspectives of children and parents have remained inconsequential. In this study, we examine the intertextual voices of children, parents, and specialists in IEPs (N = 287) drafted in Finnish early childhood education and care (ECEC). The findings show that educators use intertextual voices to serve the following functions: (1) Creating a more multidimensional image of a child, (2) presenting evidence for their argumentation, and (3) assigning the responsibility to…
Early Childhood Education and Care System in Finland
2017
In Finland, Early Childhood Education and Care (ECEC) includes day care arrangements offered to families (care) along with goal-oriented early childhood education (early education and teaching) provided for children prior to transitioning to primary education. ECEC is therefore seen to build a coherent starting phase within the continuum of lifelong learning. ECEC follows the “educare” principle, which emphasizes the simultaneous consideration for children’s education, teaching, and care as the foundation of pedagogical activity, which is at the same time strongly rooted in the idea of learning and development as a holistic experience. The aim of this article is to provide an overview of th…
Younger children in ECEC: focus on the national steering documents in the Nordic countries
2015
The aim of this study was to review the national steering documents on early childhood education and care (ECEC) in Denmark, Finland, Iceland, Norway and Sweden, with the focus on children up to the age of three, posing the question: What do these documents tell us about ECEC for younger children in the Nordic early childhood settings? Methodologically, a qualitative document analysis was applied. The documents provide a picture of young children whose age, individual needs and a number of other factors, such as cultural background, should be taken into account in ECEC. These children learn holistically, in close interaction with their environment. Their safety and well-being are seen as pa…
Documents in Interaction: A Case Study on Parent–Teacher Meetings (ECEC)
2020
Whilst the quality of early childhood education and care (ECEC) is being monitored increasingly closely, various documentation methods and practices that aim at recording and assessing children’s advancement and activities have expanded in ECEC. The research on the impact of such documentation methods on grassroots-level practices is however currently scarce. This chapter illuminates the role of a specific documentation method—that is, a child’s ECEC plan—in parent–teacher meetings in Finnish ECEC. This plan was implemented as a means to increase pedagogical quality of ECEC in Finland. The chapter considers the ECEC plan a participant during parent–teacher meetings and, by applying discursi…
Privilege or tragedy? : Educators’ accounts of flexibly scheduled early childhood education and care
2017
This article explores accounts given by Finnish educators ( n = 31) on the topic of flexibly scheduled early childhood education and care (i.e. childcare provided during non-standard as well as standard hours). Previous research has shown this to be a sensitive topic because of the contradiction between what is deemed in the interests of children and the fact of providing childcare during non-standard hours. The research follows the principles of discursive psychology. Educators’ accounts were labelled as excusing, compensating, normalising and justifying. Accounts categorised as excusing and compensating shared concern over the effects of childcare during non-standard hours on children’s w…