Search results for "CEF"
showing 10 items of 318 documents
Microgravity-induced alterations in signal transduction in cells of the immune system
2010
Since decades it is known that the activity of cells of the immune system is severely dysregulated in microgravity, however, the underlying molecular aspects have not been elucidated yet. The identification of gravity-sensitive molecular mechanisms in cells of the immune system is an important and indispensable prerequisite for the development of counteractive measures to prevent or treat disturbed immune cell function of astronauts during long-term space missions. Moreover, their sensitivity to altered gravity renders immune cells an ideal model system to understand if and how gravity on Earth is required for normal mammalian cell function and signal transduction. We investigated the effec…
Renal and nonrenal clearances of ceftriaxone at the steady-state and its relation to plasma protein binding
1995
Abstract The effect of the saturable plasma protein binding of ceftriaxone on the elimination of this drug was studied under steady-state conditions in the rat. A concentration-dependent increase in the total, renal and nonrenal clearances of total drug (bound + unbound) was observed, and it was related to the increase in the ex vivo unbound fraction of ceftriaxone as the plasma concentration increased. The nonrenal clearance of the unbound ceftriaxone showed a statistically significant decrease as the plasma concentration of the unbound drug at the steady state increased, which indicates that the nonrenal elimination of the drug (mainly by biliary excretion) is a saturable process. Renal c…
Enterobacter and Klebsiella species isolated from fresh vegetables marketed in Valencia (Spain) and their clinically relevant resistances to chemothe…
2013
Occurrence of antibiotic-resistant pathogenic or commensal enterobacteria in marketed agricultural foodstuffs may contribute to their incorporation into the food chain and constitutes an additional food safety concern. In this work, we have determined the clinically relevant resistances to 11 common chemotherapeutic agents in Enterobacter and Klebsiella isolates from fresh vegetables from various sources (supermarkets and greengrocers' shops in Valencia, Spain). A total of 96 isolates were obtained from 160 vegetables analyzed (50% positive samples): 68 Enterobacter isolates (59 E. cloacae, two E. aerogenes, two E. cancerogenus, one E. gergoviae, and four E. sakazakii, currently Cronobacter…
Sintesi, caratterizzazione e nuove strategie formulative per la somministrazione di nuovi derivati dopaminici nella terapia della malattia di Parkins…
2014
Il legittimo affidamento nel bilanciamento della Corte costituzionale e della Corte europea dei diritti dell'uomo in materia di retroattività legisla…
2018
The chapter examines the Constitutional Court's jurisprudence on legislative retroactivity, which is compared to the jurisprudential direction of the European Court of Human Rights. In particular, it is concerned with assessing the compatibility of retroactive laws to the so-called right to peaceful enjoyment of property, referred to in the European Convention on Human Rights.
Comparing the outcomes of two different approaches to CEFR-based rating of students’ writing performances across two European countries
2018
This study investigated to what extent two teams of experienced raters from different European countries (Finland and Austria), using their own CEFR-based rating scale (one holistic and one analytic), agreed on the CEFR level of students’ writing performances. Both teams rated one hundred performances written by Austrian secondary school students based on two tasks. The Finnish raters (N = 3) applied a holistic CEFR-linked rating scale consisting of verbatim CEFR descriptors developed in Finland, while the Austrian team (N = 6) used an analytic CEFR-linked rating scale consisting of four criteria developed in Austria. The ratings were analysed using the Rasch model. Although there were indi…
Assessing learners’ writing skills in a SLA study: Validating the rating process across tasks, scales and languages
2014
There is still relatively little research on how well the CEFR and similar holistic scales work when they are used to rate L2 texts. Using both multifaceted Rasch analyses and qualitative data from rater comments and interviews, the ratings obtained by using a CEFR-based writing scale and the Finnish National Core Curriculum scale for L2 writing were examined to validate the rating process used in the study of the linguistic basis of the CEFR in L2 Finnish and English. More specifically, we explored the quality of the ratings and the rating scales across different tasks and across the two languages. As the task is an integral part of the data-gathering procedure, the relationship of task p…
La lipomatosi congenita infiltrante del volto. Caso Clinico
2016
Congenital infiltrating lipomatosis of the face, first described by Beck in 1836, is a rare condition of unknown etiology, characterized by widespread infiltration of mature fat cells in the context of tissues softening of the face, with associated consequent bone deformities. It is presented as an isolated or associated condition hemimegalencephaly and neurocutaneous syndromes. We describe the case of a 10-year-old patient with known lipomatosis congenital of the face, arrived at our structure for follow up with Computed Tomography (CT) and Resonance Magnetic (RM) ..
Dinamiche di popolamento e processi di trasmissione culturale nel comprensorio madonita attraverso la ricostruzione della viabilità antica
2020
La ricerca sulle Madonie nasce con l’intenzione di approfondire l’evoluzione storica del popolamento sulla regione montana della Sicilia nord-occidentale. Il territorio, che solo in anni recenti è divenuto oggetto di più approfondite ricerche storico-archeologiche, si presenta estremamente ricco di risorse naturali e caratterizzato da un sostrato culturale variegato che abbraccia territori d’alta montagna, dediti ad una economia silvo-pastorale prettamente conservativa, e insediamenti costieri fortemente proiettati allo scambio e al commercio. A fine di comprendere lo sviluppo delle dinamiche d’insediamento di un’area molto estesa, si è proceduto anzitutto con la restituzione ipotetica dei …