Search results for "CEI"

Oligomerization of Vibrio cholerae cytolysin yields a pentameric pore and has a dual specificity for cholesterol and sphingolipids in the target memb…

1999

Vibrio cholerae cytolysin permeabilizes animal cell membranes. Upon binding to the target lipid bilayer, the protein assembles into homo-oligomeric pores of an as yet unknown stoichiometry. Pore formation has been observed with model liposomes consisting of phosphatidylcholine and cholesterol, but the latter were much less susceptible to the cytolysin than were erythrocytes or intestinal epithelial cells. We here show that liposome permeabilization is strongly promoted if cholesterol is combined with sphingolipids, whereby the most pronounced effects are observed with monohexosylceramides and free ceramide. These two lipid species are prevalent in mammalian intestinal brush border membranes…

Alterations of regional cerebral blood flow and oxygen saturation in a rat sinus-vein thrombosis model.

1996

Background and Purpose The pathophysiology of sinus-vein thrombosis (SVT) in patients and experimental animals is still poorly understood. This study was designed to examine and further elucidate the pathophysiological sequence of events, especially the relationship between local and regional blood flow and hemoglobin oxygen saturation (HbSO 2 ) detected at identical locations. The use of both parameters as outcome indicators should be compared. Methods SVT was induced by ligation of the superior sagittal sinus (SSS) and slow injection of kaolin-cephalin suspension into the SSS in rats. Regional cerebral blood flow (rCBF) was assessed by laser-Doppler flowmetry together with regional HbSO …

Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs

2019

Abstract Diseases caused by members of the order Trypanosomatidae include human African trypanosomiasis (HAT) and Chagas disease, caused by species of Trypanosoma brucei and Trypanosoma cruzi, respectively, as well as leishmaniasis, caused by various species of Leishmania spp. These infections belong to the so-called neglected tropical diseases group, which are a diverse group of communicable diseases that prevail in tropical and subtropical conditions in 149 countries and affect more than one billion people in addition to costing developing economies billions of dollars every year. The available pharmacotherapies for combatting these diseases are limited and associated with strong side eff…

The role of industry influence in sinus balloon dilation: Trends over time

2018

OBJECTIVE Balloon dilation (BD) is a controversial alternative to conventional sinus surgery. The role of industry on practice patterns remains unknown. The aim of this study was to determine whether industry payments from BD manufacturers influence practice patterns for otolaryngologists and evaluate how these payments change over time. METHODS Retrospective cohort study using Medicare Provider Utilization and Payment (PUP) Data and Center for Medicare and Medicaid Services Open Payments (OP) general payment datasets. A total of 294 otolaryngologists identified in the PUP dataset who performed BD procedures from January 1, 2013, to December 31, 2015, were cross-referenced in the OP dataset…

Multi-technical approach for the characterization of polychrome decorative surfaces at Spanish Mission Churches in Nueva Vizcaya (Chihuahua, Mexico)

2020

An interdisciplinary and multi-institutional group of science and art conservation specialists has provided new insight into the painting materials used in the polychrome walls and wooden ceilings in four seventeenth century Spanish colonial churches of Nueva Vizcaya (Chihuahua, Mexico). A multi-analytical study of the decorative surfaces was performed in situ using spectroscopic approaches (XRF, FORS), False Colour Infrared Reflectography – IRFC, as well as micro sampling for ATR-FTIR, LM and GC/MS laboratory analyses. A survey of natural resources were also studied by ATR-FTIR and LM to elucidate the natural occurrence of a select number of materials found in the surrounding areas of the …

Disentangling the dynamics of social assistance: A linked survey—Register data cohort study of long-term social assistance recipients in Norway

2020

Social assistance is a means-tested benefit that is supposed to be a short-term, temporary economic support. Understanding why some individuals are in repeated or continuous need of social assistance is thus of obvious policy relevance, but the dynamics of social assistance receipt remain poorly understood. In 2005, a survey among long-term recipients of social assistance in Norway collected data on (a) childhood disadvantages, (b) health status, (c) health behaviors, (d) psychological resources, and (e) social ties, in addition to basic sociodemographic information. This rich survey data has been linked with tax register data from 2005–2013, enabling us to explore the detailed characterist…

Child abuse/neglect risk assessment under field practice conditions: Tests of external and temporal validity and comparison with heart disease predic…

2015

AbstractObjectives (1) Identify validation design and accuracy assessment standards for medical prognostic models applicable to evaluation of child abuse/neglect (CA/N) risk assessment models. (2) Assess the accuracy of the California Family Risk Assessment (CFRA) in predicting CA/N using the foregoing standards. (3) Compare the prediction accuracy of the CFRA with the prediction accuracy of coronary heart disease (CHD) prediction models. Questions addressed (1) What validation design and accuracy assessment standards are used to evaluate medical prognostic models? (2) What is the evidence for the accuracy of the CFRA using those standards? (3) How does the accuracy of the CFRA in predictin…

Cumulative Childhood Maltreatment and Non‐Suicidal Self‐Injury: the Mediating and Moderating Role of Perceived Social Support in a Sample of Universi…

2022

Non-suicidal self-injury (NSSI) in young adults is recognized as a major public health concern. Some studies have identi- fied cumulative childhood maltreatment (CCM) as a significant vulnerability factor for NSSI, although the nature of this association remains unclear. Specifically, some theorists have investigated the role of perceived social support (PSS), con- sidered an important factor closely associated with both CCM and NSSI. The aim of the current study was to simultaneously investigate the potential mediating and moderating role of PSS from family and friends in the association between CCM and NSSI in a university student sample. Participants were 474 students (73.4% female; Mage…

Chimica dalla H alla Z. Edizione BLU - Volume BLU Dai fenomeni alle soluzioni, 1° Biennio

2019

Comment favoriser des choix de goûters favorables à la santé au sein du binôme mère-enfant ? : effet d’une intervention « nutritionnelle » ou d’une i…

2020

In France, the midafternoon snack is a frequent habit among children usually characterized by the consumption of fatty, sweet and high-energy-dense foods. If eating behaviours remain flexible and can evolve throughout the life, they are already strongly established during childhood. In this context, improve food habits in terms of midafternoon snack seem important. The thesis aim was therefore to assess the effectiveness of levers aimed at promoting healthy snack choices within mother-child dyads. A first experiment was conducted in order to assess the impact of a nutritional labelling system, the Nutri-Score, on the nutritional quality and on the liking of the snacks chosen within mother-c…