Search results for "CEI"
showing 10 items of 1294 documents
Un pionero del pensamiento crítico
2010
Para regenerar la democracia - ¡Vivan los treinta años de CEISA!
EPA-0703 – Performance of the hamilton depression rating subscales to predict antidepressant treatment response in the early course of treatment
2014
Early improvement ( EI ), i.e. a symptom reduction from baseline of at least 20% after 2 weeks, has been proven to be a clinically useful predictor for later treatment outcome. In most studies EI is identified by using the sum score of the Hamilton Depression Rating Scale (HAMD). Several unidimensional subscales of the HAMD exist, which have proven to be an economic measure of treatment change. Their ability to detect onset of improvement in comparison to the full HAMD has not been researched yet. The present study investigated in patients with major depression (MD) (1) whether the HAMD subscales are a valid and economic option to predict antidepressant treatment response in the early cours…
The predictive and incremental validity of the German adaptation of the Static-2002 in a sexual offender sample released from the prison system
2015
Purpose The aim of this study was to examine the predictive validity of the German adaptation of the Static-2002 and to compare it with the results of the Static-99. Method The predictive validity of Static-2002 was investigated in a sample of n = 452 sexual offenders released from the Austrian Prison System. The instrument was coded retrospectively using file information. Afterwards, the predictive estimates of the Static-2002 were related to officially documented reconviction data. Results The Static-2002 was found to have large effect sizes for predicting sexual, violent, and general recidivism (area under the receiver operating characteristic curve [AUC] = .78, .75, .75, respectively) f…
The Development of the Brief Eating Disorder in Athletes Questionnaire
2014
MARTINSEN, M., I. HOLME, A. M. PENSGAARD, M. K. TORSTVEIT, and J. SUNDGOT-BORGEN. The Development of the Brief Eating Disorder in Athletes Questionnaire. Med. Sci. Sports Exerc., Vol. 46, No. 8, pp. 1666–1675, 2014. Purpose: The objective of this study is to design and validate a brief questionnaire able to discriminate between female elite athletes with and without an eating disorder (ED). Methods: In phase I, 221 (89.5%) adolescent athletes participated in a screening including the Eating Disorder Inventory-2 (EDI2) and questions related to ED. All athletes reporting symptoms associated with ED (n = 96, 94.1%) and a random sample without symptoms (n = 88, 86.3%) attended the ED Examinatio…
Latent Class Model to Test the Preferences Heterogeneity in the Perceived Information by Public Transport Users
2012
The aim of analysis is to understand as not reliable information influence the user behaviour and how much disincentive the public transport use. For this purpose, a Stated Preference Survey has been carried out in order to know the preferences of public transport users related to information needs and uncertainty on the information provided by Advanced Traveller Information System (ATIS). The perceived uncertainty is defined as the information accuracy. In our study, it was considered the difference between forecasted or scheduled waiting time at the bus stop and/or metro station provided by ATIS, and experienced one by user, to catch the bus and/or metro respectively. A questionnaire has …
Intrahistoria del presente
2007
2012
Diazepinomicin is a dibenzodiazepine alkaloid with an unusual structure among the known microbial metabolites discovered so far. Diazepinomicin was isolated from the marine sponge-associated strain Micromonospora sp. RV115 and was identified by spectroscopic analysis and by comparison to literature data. In addition to its interesting preclinical broad-spectrum antitumor potential, we report here new antioxidant and anti-protease activities for this compound. Using the ferric reducing antioxidant power (FRAP) assay, a strong antioxidant potential of diazepinomicin was demonstrated. Moreover, diazepinomicin showed a significant antioxidant and protective capacity from genomic damage induced …
Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Frac…
2014
In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 mu M and without cytotoxic effects against J774.1 macrophages at 100 mu M concentration. Plakortide E was isolated from the sponge Plakortis halichondroides using enzyme assay-guided fractionation and identified by NMR spectroscopy and mass spectrometry. Furthermore, enzyme kinetic studies confirmed plakortide E as a non-competitive, slowly-binding, reversible inhibitor of rhodesain.
Conformational changes involved in thermal aggregation processes of bovine serum albumin
2003
We report a kinetic study on thermal aggregation process of the model protein bovine serum albumin (BSA) in low concentration regime. Aim of this study is to provide information on relationship between conformational changes and initial step of aggregation. The experimental approach is based on steady-state fluorescence spectra of the two tryptophans located in two different domains, in way to study conformational changes in the surrounding of these residues. We also follow emission spectra of Fluorescein-5-Maleimide dye bound to the single free cysteine of BSA. Complementary information on the extent of aggregation and on the structural changes is obtained by Rayleigh scattering and circul…