Search results for "CELL"
showing 10 items of 65972 documents
Performance et éthique
2010
National audience; ...
La libertad incorporada como clave para la neuroeducación moral
2019
La libertad es uno de los principales atributos con los que tradicionalmente se ha caracterizado al ser humano. El objetivo de este artículo es analizar si a la luz de las investigaciones y los experimentos neurocientíficos es posible seguir caracterizando al ser humano como un ser con libertad. Para ello se alude al conocido experimento de Benjamin Libet y las conclusiones reduccionistas que influyentes autores como Patricia S. Churchland o Michael Gazzaniga extraen para la filosofía práctica. Desde una metodología hermenéutica, se denuncia el reduccionismo neurocientífico que pretende negar la libertad basándose en evidencias empíricas. Frente a dicho reduccionismo se propone un enfoque h…
Malmenées, vivantes et nécessaires : les études ouvrières en France
2012
International audience
Annales des travaux des auditeurs de l'IHEDN 2006 : "Les évolutions récentes en Chine"
2006
CD rom; International audience
Image verbale, image picturale dans l’œuvre de Bachelard
2012
International audience
CCDC 1490706: Experimental Crystal Structure Determination
2017
Related Article: Diego Rota Martir, Cristina Momblona, Antonio Pertegás, David B. Cordes, Alexandra M. Z. Slawin, Henk J. Bolink, and Eli Zysman-Colman|2016|ACS Applied Materials and Interfaces|8|33907|doi:10.1021/acsami.6b14050
Up-regulation of the α-Secretase Pathway
2007
An arthritogenic alphavirus uses the α1β1 integrin collagen receptor
2005
Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding alpha1beta1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the beta1 and alpha1 integrin proteins, and fibroblasts from alpha1-integrin-/- mice were less efficiently infected than wild-type fibroblasts. Soluble alpha1beta1 integrin bound immobilized RR virus, and peptides representing the alpha1beta1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions with…
α-Conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors
2003
The Xenopus laevis oocyte expression system was used to determine the activities of alpha-conotoxins EpI and the ribbon isomer of AuIB, on defined nicotinic acetylcholine receptors (nAChRs). In contrast to previous findings on intracardiac ganglion neurones, alpha-EpI showed no significant activity on oocyte-expressed alpha3beta4 and alpha3beta2 nAChRs but blocked the alpha7 nAChR with an IC50 value of 30 nM. A similar IC50 value (103 nM) was obtained on the alpha7/5HT3 chimeric receptor stably expressed in mammalian cells. Ribbon AuIB maintained its selectivity on oocyte-expressed alpha3beta4 receptors but unlike in native cells, where it was 10-fold more potent than native alpha-AuIB, had…
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
2021
The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…