Search results for "CELLULAR"
showing 10 items of 6449 documents
AAV-Mediated Clarin-1 Expression in the Mouse Retina: Implications for USH3A Gene Therapy
2015
Usher syndrome type III (USH3A) is an autosomal recessive disorder caused by mutations in clarin-1 (CLRN1) gene, leading to progressive retinal degeneration and sensorineural deafness. Efforts to develop therapies for preventing photoreceptor cell loss are hampered by the lack of a retinal phenotype in the existing USH3 mouse models and by conflicting reports regarding the endogenous retinal localization of clarin-1, a transmembrane protein of unknown function. In this study, we used an AAV-based approach to express CLRN1 in the mouse retina in order to determine the pattern of its subcellular localization in different cell types. We found that all major classes of retinal cells express AAV…
Molecular phylogeny of Metazoa (animals): monophyletic origin.
1995
The phylogenetic relationships within the kingdom Animalia (Metazoa) have long been questioned. Focusing on the lowest eukaryotic multicellular organisms, the metazoan phylum Porifera (sponges), it remained unsolved if they evolved multicellularity independently from a separate protist lineage (polyphyly of animals) of derived from the same protist group as the other animal phyla (monophyly). After having analyzed genes typical for multicellularity (adhesion molecules/receptors and a nuclear receptor), we present evidence that Porifera should be placed in the kingdom Animalia. We therefore suggest a monophyletic origin for all animals.
Dynamic Pattern Recognition in Sport by Means of Artificial Neural Networks
2008
Behavioural processes like those in sports, motor activities or rehabilitation are often the object of optimization methods. Such processes are often characterized by a complex structure. Measurements considering them may produce a huge amount of data. It is an interesting challenge not only to store these data, but also to transform them into useful information. Artificial Neural Networks turn out to be an appropriate tool to transform abstract numbers into informative patterns that help to understand complex behavioural phenomena. The contribution presents some basic ideas of neural network approaches and several examples of application. The aim is to give an impression of how neural meth…
Bifurcation of traveling waves in a Keller–Segel type free boundary model of cell motility
2018
We study a two-dimensional free boundary problem that models motility of eukaryotic cells on substrates. This problem consists of an elliptic equation describing the flow of cytoskeleton gel coupled with a convection-diffusion PDE for the density of myosin motors. The two key properties of this problem are (i) presence of the cross diffusion as in the classical Keller-Segel problem in chemotaxis and (ii) nonlinear nonlocal free boundary condition that involves curvature of the boundary. We establish the bifurcation of the traveling waves from a family of radially symmetric steady states. The traveling waves describe persistent motion without external cues or stimuli which is a signature of …
Can the Double Exchange Cause Antiferromagnetic Spin Alignment?
2020
The effect of the double exchange in a square-planar mixed-valence dn+1&minus
Sensitivity to Initial Conditions in an Extended Activator--Inhibitor Model for the Formation of Patterns
2018
Despite simplicity, the synchronous cellular automaton [D.A. Young, Math. Biosci. 72, 51 (1984)] enables reconstructing basic features of patterns of skin. Our extended model allows studying the formatting of patterns and their temporal evolution also on the favourable and hostile environments. As a result, the impact of different types of an environment is accounted for the dynamics of patterns formation. The process is based on two diffusible morphogens, the short-range activator and the long-range inhibitor, produced by differentiated cells (DCs) represented as black pixels. For a neutral environment, the extended model reduces to the original one. However, even the reduced model is stat…
Field analysis of the magnetic systems for tubular linear reluctance motors
2005
We report a study of tubular linear reluctance motors (TLRMs) in various types of magnetic circuits. We carried out magnetic field analyses and calculated integral parameters of the field. We also determined static characteristics and electromagnetic parameters of the motor. We found good agreement between our calculations and tests of the motor with sinusoidal excitation.
Nonlinear energy dissipation in a cellular automaton magnetotail field model
1999
A magnetic field model of the magnetotail current sheet based on cellular automaton (CA) is presented. The present isotropic model is a continuously driven, two-dimensional running CA. The model has a physical interpretation in terms of magnetohydrodynamic (MHD) equations, and features self-organized critical (SOC) behavior with power-law scalings both in durations and sizes of instabilities (avalanches). The model has nonlinear energy dissipation, and shows avalanches with and without an external trigger. Thus the model reproduces some of the statistical features recently observed in the magnetotail.
Toward multifunctional molecular cells for quantum cellular automata: exploitation of interconnected charge and spin degrees of freedom
2021
We discuss the possibility of using mixed-valence (MV) dimers comprising paramagnetic metal ions as molecular cells for quantum cellular automata (QCA). Thus, we propose to combine the underlying idea behind the functionality of QCA of using the charge distributions to encode binary information with the additional functional options provided by the spin degrees of freedom. The multifunctional ('smart') cell is supposed to consist of multielectron MV d(n)-d(n+1)-type (1 ≤ n ≤ 8) dimers of transition metal ions as building blocks for composing bi-dimeric square planar cells for QCA. The theoretical model of such a cell involves the double exchange (DE), Heisenberg-Dirac-Van Vleck (HDVV) excha…
Sperrarterien in der Aderhaut und am Sehnerveneintritt beim Hund.
1954
In der Aderhaut und am Sehnerveneintritt beim Hund werden Sperrarterien beschrieben, die mit zahlreichen Langsmuskelpolstern in der Intima ausgestattet sind und offenbar der Regulation der Aderhautdurchblutung dienen. Auch andere Besonderheiten am Gefassystem im Bereich des Sehnerveneintritts (Venenplexus, arteriovenose Anastomosen) konnten nachgewiesen werden. Weder bei der Katze, beim Kaninchen, Meerschweinchen oder Menschen kommen ahnliche Gefasregulationseinrichtungen vor.