Search results for "CELLULAR"
showing 10 items of 6449 documents
Membrane Fouling Mitigation in MBR via the Feast–Famine Strategy to Enhance PHA Production by Activated Sludge
2022
Fouling is considered one of the main drawbacks of membrane bioreactor (MBR) technology. Among the main fouling agents, extracellular polymeric substances (EPS) are considered one of the most impactful since they cause the decrease of sludge filterability and decline of membrane flux in the long term. The present study investigated a biological strategy to reduce the membrane-fouling tendency in MBR systems. This consisted of seeding the reactor with activated sludge enriched in microorganisms with polyhydroxyalkanoate (PHA) storage ability and by imposing proper operating conditions to drive the carbon toward intracellular (PHA) rather than extracellular (EPS) accumulation. For that purpos…
Digital control circuitry for the p53 dynamics in cancer cell and apoptosis
2010
Experimental work and theoretical models deduce a "digital" response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in feedback. This paper proposes an aerospace architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is not to improve the analysis of the actual mathematical models but to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dyn…
A Ferrite Tubular Linear Motor (FTLM): Analysis and design
2015
The electromagnetic linear machines have wide applications in the electromagnetic aircraft launch systems [1] and in transportation systems [2]. Additional energy saving and efficiency can be achieved using a linear motor in the refrigeration application [3]. Linear electromagnetic machines are also very suitable for high-speed packaging, manufacturing sectors and precision positioning. There are different linear motor topologies. Tubular permanent-magnets are particularly attractive since they have a high thrust force density and high efficiency, no end windings, and zero net attractive force between stator and armature. There are various tubular motor topologies, in which the armature may…
Microscopic evidence of the primary astrocytes' morphological differentiation and migration inside porous Poly-L-lactic acid 3D‑scaffolds
2019
Tissue engineering is an emerging multidisciplinary field that aims at reproducing in vitro and/or in vivo tissues with morphological and functional features similar to the biological tissue of the human body [1]. In the attempt to construct suitable tissue models, a critical step is the setting of 3D scaffolds that mimic the supportive structures of a natural extracellular matrix microenvironment into which cells are normally embedded. In this context, the generation of 3D cultures of brain cells is of particular interest. For instance, the poly L‐lactic acid (PLLA) polymer is wildly used because of its biocompatible and biodegradable potential; the PLLA scaffold topography simulates the n…
Tubular scaffold for vascular tissue engineering application
2010
A critical obstacle in tissue engineering is the inability to maintain large masses of living cells upon transfer from the in vitro culture conditions into the host in vivo. Capillaries, and the vascular system, are required to supply essential nutrients, including oxygen, remove waste products and provide a biochemical communication “highway”. Another goal in this research field is the possibility to tune the biodegradability of the scaffold. After implantation, the scaffold has to be gradually replaced by cells and extra cellular matrix and it is crucial that this replacement takes place with an appropriate dynamics. A premature degradation, in fact, could lead to a collapse of the struct…
Performance of LoRa technology: link-level and cell-level performance
2020
Abstract LoRa is a chirp spread spectrum technology that is becoming very popular for low-power wide-area networks, with high-density devices. In this chapter, we study the capacity of LoRa in rejecting different interfering signals. First, we analyze LoRa modulation numerically demonstrating that channel captures appear easily and that collisions between packets modulated with different spreading factors (SFs) are not uncommon. We validate such findings in experiments based on commercial devices and software-defined radios. Second, we model the network capacity obtainable in a typical LoRa cell: we show that high SFs can be seriously influenced by inter-SF collisions and that fading has a …
A Reconfigurable Neural Environment on Active Networks
2000
This paper proposes the deployment of a neural network computing environment on Active Networks. Active Networks are packet-switched computer networks in which packets can contain code fragments that are executed on the intermediate nodes. This feature allows the injection of small pieces of codes to deal with computer network problems directly into the network core, and the adoption of new computing techniques to solve networking problems. The goal of our project is the adoption of a distributed neural network for approaching tasks which are specific of the computer network environment. Dynamically reconfigurable neural networks are spread on an experimental wide area backbone of active no…
METABOLIC NETWORKS ROBUSTNESS: THEORY, SIMULATIONS AND RESULTS
2011
Metabolic networks are composed of several functional modules, reproducing metabolic pathways and describing the entire cellular metabolism of an organism. In the last decade, an enormous interest has grown for the study of tolerance to errors and attacks in metabolic networks. Studies on their robustness have suggested that metabolic networks are tolerant to errors, but very vulnerable to targeted attacks against highly connected nodes. However, many findings on metabolic networks suggest that the above classification is too simple and imprecise, since hub node attacks can be by-passed if alternative metabolic paths can be exploited. On the contrary, non-hub nodes attacks can affect cell …
Three-dimensional matching based resource provisioning for the design of low-latency heterogeneous IoT networks
2019
Internet-of-Things (IoT) is a networking architecture where promising, intelligent services are designed via leveraging information from multiple heterogeneous sources of data within the network. However, the availability of such information in a timely manner requires processing and communication of raw data collected from these sources. Therefore, the economic feasibility of IoT-enabled networks relies on the efficient allocation of both computational and communication resources within the network. Since fog computing and 5G cellular networks approach this problem independently, there is a need for joint resource-provisioning of both communication and computational resources in the networ…
Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
2022
Neutrophil extracellular traps (NETs) are web-like chromatin structures composed by dsDNA and histones, decorated with antimicrobial proteins. Their interaction with dendritic cells (DCs) allows DC activation and maturation toward presentation of NET-associated antigens. Differently from other types of cell death that imply protein denaturation, NETosis preserves the proteins localized onto the DNA threads for proper enzymatic activity and conformational status, including immunogenic epitopes. Besides neutrophils, leukemic cells can release extracellular traps displaying leukemia-associated antigens, prototypically mutant nucleophosmin (NPMc+) that upon mutation translocates from nucleolus …