Search results for "CELLULAR"

Waiting-time and quality of care deserved to patients with early stage hepatocellular carcinoma undergoing RFA treatment

2017

Impact of membrane addition for effluent extraction on the performance and sludge characteristics of upflow anaerobic sludge blanket reactors treatin…

2015

Abstract In this study, the impact of membrane incorporation for effluent extraction on the performance of an upflow anaerobic sludge blanket (UASB) reactor treating municipal wastewater was investigated in terms of system performance and sludge characteristics. A laboratory-scale system was operated in two different operational stages: (i) as a sole UASB reactor and (ii) as an anaerobic membrane bioreactor (AnMBR). Membrane incorporation induced an accumulation of fine particles and a decrease in extracellular polymeric substances (EPS), resulting in a decrease in particle size distribution (PSD) and, thus, a drop in sludge settleability. Deterioration of sludge settleability led to an inc…

Editorial - Connecting the Dots: The Promises of Wharton's Jelly Mesenchymal Stem Cells for Tissue Repair and Regeneration

2011

Mesenchymal stem cells (MSC) constitute a variety of cellular populations which were described first about 35 years ago in the bone marrow (BM) stroma [1]. These years have foreseen an exponential increase of reports pointing out features, stemness, markers, tissue sources and clinical applications of these cells. Cells with MSC features can be isolated from virtually every adult organ in the body, as well from a group of fetus-associated sources (cells derived from the latter tissues are collectively known as perinatal stem cells) [2]. In recent years, the umbilical cord arose as a promising source of mesenchymal stem cells, which can be isolated in relatively high numbers (compared to BM)…

Temperature-dependence of spontaneous mutation rates

2020

Mutation is the source of genetic variation and the fundament of evolution. At the interphase of ecology and evolution, temperature has long been suggested to have a direct impact on realised spontaneous mutation rates. The question is whether mutation rates can be a species-specific constant under variable environmental conditions, such as variation of the ambient temperature. By combining mutation accumulation with whole genome sequencing in a multicellular organism, we provide empirical support to reject this null hypothesis. Instead mutation rates depend on temperature in a U-shaped manner with increasing rates towards both temperature extremes. This relation has important implications …

Booster vaccination after neonatal priming with acellular pertussis vaccine.

2010

After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/ Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.

Clinical Utility of a Unique Genome-Wide DNA Methylation Signature for KMT2A-Related Syndrome

2022

Wiedemann–Steiner syndrome (WDSTS) is a Mendelian syndromic intellectual disability (ID) condition associated with hypertrichosis cubiti, short stature, and characteristic facies caused by pathogenic variants in the KMT2A gene. Clinical features can be inconclusive in mild and unusual WDSTS presentations with variable ID (mild to severe), facies (typical or not) and other associated malformations (bone, cerebral, renal, cardiac and ophthalmological anomalies). Interpretation and classification of rare KMT2A variants can be challenging. A genome-wide DNA methylation episignature for KMT2A-related syndrome could allow functional classification of variants and provide insights into the pathoph…

Man's strategy in domestication - a synthesis of new research trends.

1976

The minimum brain size possible in the relevant wild species and certain colour types which, because of alterations in the neurotransmitter system caused by the respective colour genes, are related to behavioural traits diverging from the wild animal's norm appear to be first-rate bases for domestication either separately or in combination.

Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

2016

AbstractInactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tissues from the side effects of anti-cancer treatment. In this study, we decided to search for kinases that prevent Wip1-mediated sensitization of cancer cells, thereby interfering with efficacy of genotoxic anti-cancer drugs. To this end, we performed a flow cytometry-based screening in order to identify kinases that regulated the levels of γH2AX, which were used as readout. Another criter…

Power consumption analysis for mobile stations in hybrid relay-assisted wireless networks

2010

While Internet access using mobile or wireless technologies has become ubiquitous these days, the energy consumption aspect of such connections has not been studied in-depth yet. In this paper, a hybrid wireless network, which consists of a cellular component and a relay-assisted ad hoc component, is studied focusing on energy consumption by mobile stations with respect to the amount of data communicated and achieved battery lifetime. Four alternative paths are considered, including both pure cellular and hybrid ad hoc/cellular links for uplink and downlink traffic. The effects of each alternative connection on energy consumption of the involved mobile stations are analyzed in terms of the …

Translocation time of periodically forced polymer chains.

2010

6 páginas, 11 figuras.-- PACS number(s): 36.20.-r, 05.40.-a, 87.15.A-, 87.10.-e