Search results for "CFT"
showing 10 items of 54 documents
On AdS7 stability
2019
AdS$_7$ supersymmetric solutions in type IIA have been classified, and they are infinitely many. Moreover, every such solution has a non-supersymmetric sister. In this paper, we study the perturbative and non-perturbative stability of these non-supersymmetric solutions, focusing on cases without orientifolds. Perturbatively, we first look at the KK spectrum of spin-2 excitations. This does not exhibit instabilities, but it does show that there is no separation of scales for either the BPS and the non-BPS case, thus proving for supersymmetric AdS$_7$ a well-known recent conjecture. We then use 7d gauged supergravity and a brane polarization computation to access part of the spectrum of KK sc…
Finite size spectrum of SU(N) principal chiral field from discrete Hirota dynamics
2016
Using recently proposed method of discrete Hirota dynamics for integrable (1+1)D quantum field theories on a finite space circle of length L, we derive and test numerically a finite system of nonlinear integral equations for the exact spectrum of energies of SU(N)xSU(N) principal chiral field model as functions of m L, where m is the mass scale. We propose a determinant solution of the underlying Y-system, or Hirota equation, in terms of determinants (Wronskians) of NxN matrices parameterized by N-1 functions of the spectral parameter, with the known analytical properties at finite L. Although the method works in principle for any state, the explicit equations are written for states in the …
Weak and strong coupling equilibration in nonabelian gauge theories
2015
We present a direct comparison studying equilibration through kinetic theory at weak coupling and through holography at strong coupling in the same set-up. The set-up starts with a homogeneous thermal state, which then smoothly transitions through an out-of-equilibrium phase to an expanding system undergoing boost-invariant flow. This first apples-to-apples comparison of equilibration provides a benchmark for similar equilibration processes in heavy-ion collisions, where the equilibration mechanism is still under debate. We find that results at weak and strong coupling can be smoothly connected by simple, empirical power-laws for the viscosity, equilibration time and entropy production of t…
Properties of some conformal field theories with M-theory duals
2007
24 pages.-- ISI Article Identifier: 000245078200049.-- ArXiv pre-print available at: http://arxiv.org/abs/hep-th/0611219
Yangian Symmetry for Fishnet Feynman Graphs
2017
Various classes of fishnet Feynman graphs are shown to feature a Yangian symmetry over the conformal algebra. We explicitly discuss scalar graphs in three, four and six spacetime dimensions as well as the inclusion of fermions in four dimensions. The Yangian symmetry results in novel differential equations for these families of largely unsolved Feynman integrals. Notably, the considered fishnet graphs in three and four dimensions dominate the correlation functions and scattering amplitudes in specific double scaling limits of planar, gamma-twisted N=4 super Yang-Mills or ABJM theory. Consequently, the study of fishnet graphs allows us to get deep insights into the integrability of the plana…
Identificazionee caratterizzazione di mutazioni in regioni regolatorie del gene malattia della fibrosi cistica
2013
Mutation epidemiology is crucial for cystic fibrosis (CF) diagnosis and counselling. ~6%-7% of alleles from CF patients do not bear mutations in the coding regions of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease gene. In these patients, mutations may be present in non-coding, regulatory regions of the gene as i) intronic regions (particularly in high conserved sequences), ii) the promoter region or iii) the area at the 3’ of the gene, which is the target of microRNA regulation. We studied these regions by gene sequencing in a group of CF patients with one or both unidentified mutations after the analysis of CFTR coding regions, and in a group of CF patients with a different cl…
Treatment of Pulmonary Disease of Cystic Fibrosis: A Comprehensive Review.
2021
Cystic fibrosis (CF) is a genetic disease that causes absence or dysfunction of a protein named transmembrane conductance regulatory protein (CFTR) that works as an anion channel. As a result, the secretions of the organs where CFTR is expressed are very viscous, so their functionality is altered. The main cause of morbidity is due to the involvement of the respiratory system as a result of recurrent respiratory infections by different pathogens. In recent decades, survival has been increasing, rising by around age 50. This is due to the monitoring of patients in multidisciplinary units, early diagnosis with neonatal screening, and advances in treatments. In this chapter, we will approach t…
Ultimate Shear of RC Beams with Corroded Stirrups and Strengthened with FRP
2019
Transverse reinforcement plays a key role in the response behavior of reinforced concrete beams. Therefore, corrosion of steel stirrups may change the failure mode of elements from bending to shear, leading to a brittle and catastrophic crisis. It is important to strengthen reinforced concrete beams with corroded stirrups to enhance the shear resistance. This paper presents a formulation, based on the modified compression field theory, to estimate the ultimate shear of reinforced concrete beams strengthened with FRP, because of stirrup corrosion. The detrimental effect of corrosion on steel stirrup yield strength was taken into account by introducing an empirical decay law. The effective st…
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
2023
AbstractF508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological correctors, such as VX-809 and VX-445, that stabilize CFTR and improve its trafficking to plasma membrane. Using a functional test to evaluate a panel of chemical compounds, we have identified tricyclic pyrrolo-quinolines as novel F508del correctors with high efficacy on primary airway epithelial cells from CF patients. The most effective compound, PP028, showed synergy when combined with VX-809 and VX-661 but not with VX-445. By testing the …
Scalar spectrum in a graviton soft wall model
2020
In this study we present a unified phenomenological analysis of the scalar glueball and scalar meson spectra within an AdS/QCD framework in the bottom up approach. For this purpose we generalize the recently developed graviton soft-wall (GSW) model, which has shown an excellent agreement with the lattice QCD glueball spectrum, to a description of glueballs and mesons with a unique energy scale. In this scheme, dilatonic effects, are incorporated in the metric as a deformation of the AdS space. We apply the model also to the heavy meson spectra with success. We obtain quadratic mass equations for all scalar mesons while the glueballs satisfy an almost linear mass equation. Besides their spec…