Search results for "CHRONIC DISEASE"

showing 10 items of 792 documents

Fecal Calprotectin in Clinical Practice

2012

Background: Surrogate markers of colorectal inflammation are increasingly being recognized as important in differentiating organic from functional intestinal disorders. Fecal calprotectin (FC) can be easily measured in the stool, being released by leukocytes in inflammatory conditions. Aim: We evaluated FC as an index of inflammation in consecutive outpatients referred for colonoscopy for chronic, nonbloody diarrhea. Methods: Stool specimens of 346 outpatients with chronic, nonbloody diarrhea, referred for colonoscopy, were measured for FC levels. The proportion of patients correctly diagnosed with the test and the relationship with endoscopic and histologic findings were measured. Results:…

AdultDiarrheaMalemedicine.medical_specialtySettore MED/09 - Medicina InternaAdolescentdiarrheaColonoscopyInflammationSettore MED/08 - Anatomia PatologicaSensitivity and SpecificityGastroenterologyFecesYoung AdultPredictive Value of TestsInternal medicinemedicineHumansScreening toolProspective StudiesFecesAgedAged 80 and overInflammationSettore MED/12 - Gastroenterologiamedicine.diagnostic_testbusiness.industryGastroenterologyHistologyColonoscopyMiddle AgedEndoscopyDiarrheaChronic DiseaseFemalemedicine.symptomCalprotectinbusinessLeukocyte L1 Antigen ComplexJournal of Clinical Gastroenterology
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Soluble-protein and antigenic heterogeneity in axenic Blastocystis hominis isolates: pathogenic implications.

1999

The protein profile and the antigenic cross-reactivity of 18 axenic isolates of Blastocystis hominis obtained from symptomatic patients with chronic diarrhea (14 isolates) showing no evidence of parasitic etiology and from patients with acute diarrhea attributable in 2 cases to Salmonella spp. were analyzed. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of soluble proteins showed the existence of a common profile composed of 31 bands, with molecular weights ranging between 24 and >200 kDa, and minor differences in the proteins of 149, 118, 106, 50, 48, 47, and 30 kDa. These differences allowed us to classify the strains into three related patterns (I–III). In an indirect immunof…

AdultDiarrheaSalmonellaImmunodiffusionProtozoan ProteinsAntigens ProtozoanHIV InfectionsBlastocystis InfectionsBiologyLoboseaCross Reactionsmedicine.disease_causeMicrobiologyAntigenmedicineAnimalsHumansBlastocystis hominisAxenicGel electrophoresisBlastocystisGeneral VeterinaryGeneral Medicinebiology.organism_classificationVirologyMolecular WeightDiarrheaInfectious DiseasesInsect ScienceAcute DiseaseChronic DiseaseSalmonella InfectionsProtozoaParasitologyElectrophoresis Polyacrylamide Gelmedicine.symptomParasitology research
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Elevated Pressure in the Dorsal Part of Pancreas Divisum

1988

Summary In 6 patients with upper abdominal pain of unknown origin presenting with pancreas divisum, the pressure in the pancreatic duct was measured via the minor papilla into which in these patients the main part of the pancreatic duct system drains. For comparison intraductal manometry via the major papilla (papilla of Vater) was performed in 8 patients with normal pancreatic duct system. The pressure in the pancreatic duct of the control group was 10.5 ± 0.9 mm Hg. whereas in the patients with pancreas divisum it was 23.7 ± 1.3 mm Hg. The results demonstrate that in patients with pancreas divisum, intraductal pressure may be largely increased even in the fasting state.

AdultDorsummedicine.medical_specialtyManometryEndocrinology Diabetes and MetabolismGastroenterologyEndocrinologyInternal medicineInternal MedicinemedicineHumansIn patientPancreasPancreatic ductPancreas divisumHepatologybusiness.industryGeneral surgeryPancreatic Ductsmedicine.diseaseMajor duodenal papillamedicine.anatomical_structurePancreatitisUpper abdominal painChronic DiseasePancreatitisBile DuctsbusinessPancreasPancreas
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Chronic Thromboembolic Pulmonary Hypertension: Pre- and Postoperative Assessment with Breath-hold MR Imaging Techniques

2004

To evaluate the potential of breath-hold magnetic resonance (MR) imaging techniques in morphologic and functional assessment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) before and after surgery.Thirty-four patients with CTEPH were examined before and after pulmonary thromboendarterectomy (PTE). For morphologic assessment, contrast material-enhanced MR angiography was used; for assessment of hemodynamics, velocity-encoded gradient-echo sequences and cine gradient-echo sequences along the short axis of the heart were performed. Contrast-enhanced MR angiography was compared with selective digital subtraction angiography (DSA) for depiction of central thromboembolic m…

AdultGadolinium DTPAMalemedicine.medical_specialtyHypertension Pulmonarymedicine.medical_treatmentContrast MediaMagnetic Resonance Imaging CineEndarterectomyPulmonary ArterySensitivity and SpecificityVentricular Function LeftMagnetic resonance angiographyPostoperative ComplicationsHeart SeptumImage Processing Computer-AssistedmedicineHumansRadiology Nuclear Medicine and imagingProspective StudiesAgedThrombectomyEndarterectomymedicine.diagnostic_testPulmonary thromboendarterectomybusiness.industryHemodynamicsAngiography Digital SubtractionMagnetic resonance imagingDigital subtraction angiographyMiddle AgedImage Enhancementmedicine.diseaseMagnetic Resonance ImagingPulmonary hypertensionmedicine.anatomical_structureChronic DiseaseAngiographyVentricular Function RightFemaleRadiologyPulmonary EmbolismbusinessBlood Flow VelocityMagnetic Resonance AngiographyFollow-Up StudiesArteryRadiology
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Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

2017

Abstract Background and Aims Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance. Methods We performed a Mendelian randomization analysis using risk alleles in PNPLA3, TM6SF2, GCKR and MBOAT7, and a polygenic risk score for hepatic fat, as instruments. We evaluated complementary cohorts of at‐risk individuals and individuals from the general population: 1515 from the liver biopsy cohort (LBC), 3329 from the Swedish Obese Subjects Study (SOS) and 4570 from the population‐based Dallas Heart Study (DHS). Re…

AdultGenetic MarkersLiver CirrhosisMalenonalcoholic fatty liver diseaseNon-alcoholic Fatty Liver Diseaseinsulin resistanceHumansgeneticsProspective StudiesAdaptor Proteins Signal TransducingSettore MED/12 - GastroenterologiafibrosisMembrane ProteinsOriginal ArticlesLipaseMendelian Randomization AnalysisAdipose TissueDiabetes Mellitus Type 2Chronic Diseasemendelian randomizationOriginal ArticleFemaletype 2 diabetesgeneticfibrosiAcyltransferases
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The new HFA/ICOS risk assessment tool to identify patients with chronic myeloid leukaemia at high risk of cardiotoxicity

2022

AimsTyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukaemia (CML) can cause cardiovascular adverseevents. So far, the Systematic Coronary Risk Evaluation (SCORE) charts of the European Society of Cardiology (ESC) have beenused to identify cancer patients at increased cardiovascular risk. The primary aim of our study was to evaluate the usefulnessof the new cardiovascular risk assessment model proposed by the Cardio-Oncology Study Group of the Heart Failure Associ-ation (HFA) of the ESC in collaboration with the International Cardio-Oncology Society (ICOS) to stratify the cardiovascular riskin CML patients, compared with SCORE risk charts. The secondary aim was to establish…

AdultHeart FailureMaleAspirinMiddle AgedRisk AssessmentCardio-oncology Cardiovascular prevention Chronic myeloid leukaemia Nilotinib Ponatinib Cardiovascular toxicityCardiotoxicityInducible T-Cell Co-Stimulator ProteinLeukemia Myelogenous Chronic BCR-ABL PositiveChronic DiseaseHumansFemaleCardiology and Cardiovascular MedicineAgedRetrospective StudiesESC Heart Failure
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HLA-DRB1*1301 AND *1302 protect against chronic hepatitis B

1997

Abstract Background/Aims: The outcome of acute hepatitis B infection may be influenced by host factors like the major histocompatibility complex (MHC). We have investigated MHC class I and class II antigens in patients with chronic hepatitis B compared to a healthy control population. To confirm the findings of this first study we performed a second study in a group of subjects who had spontaneously recovered from acute hepatitis B infection. Methods: Frequencies of MHC class I and class II antigens were analyzed in patients with chronic hepatitis B virus infection and in control subjects. MHC class I typing was done by standard microlymphocytotoxicity assays. DRB1 and DQA1 genotypes were d…

AdultHepatitis B virusRemission SpontaneousPopulationEnzyme-Linked Immunosorbent AssayMajor histocompatibility complexmedicine.disease_causePolymerase Chain ReactionHLA-DQ alpha-ChainsVirusHLA-DQ AntigensMHC class ImedicineHumansSerologic TestsProspective StudiesHepatitis B AntibodieseducationHLA-DRB1AllelesHepatitis B viruseducation.field_of_studyMHC class IIHepatitis B Surface AntigensHepatologybiologyHLA-DR AntigensHepatitis BVirologyChronic infectionImmunoglobulin GChronic DiseaseDNA ViralImmunologybiology.proteinHLA-DRB1 ChainsJournal of Hepatology
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Monosodium benzoate hypersensitivity in subjects with persistent rhinitis

2004

Background:  Very few data are available from the literature on whether nonatopic subjects affected by persistent rhinitis may show the appearance of objective symptoms of rhinitis after the ingestion of food additives such as tartrazine (E102), erythrosine (E127), monosodium benzoate (E211), p-hydroxybenzoate (E218), sodium metabisulphite (E223), and monosodium glutamate (E620). It is still unclear whether the ingestion of food additive may cause, as well, a consensual reduction of nasal peak inspiratory flow (NPIFR). Therefore, we used a double-blind placebo-controlled (DBPC) study to evaluate this hypothesis. Patients and methods:  Two hundred and twenty-six consecutive patients (76 male…

AdultHypersensitivity ImmediateMaleAllergymedicine.medical_specialtySettore MED/09 - Medicina InternaAdolescentMonosodium glutamateImmunologyGastroenterologychemistry.chemical_compoundVasomotor RhinitisInternal medicineImmunopathologySodium BenzoatemedicineImmunology and AllergyIngestionHumansMonosodium benzoate; hypersensitivity; persistent rhinitisChildRhinitisbusiness.industryMonosodium benzoatedouble-blind placebo-controlledMiddle Agednasal peak inspiratory flowmedicine.diseasefood additivesRegimenchemistryImmunologyChronic DiseaseEtiologyFood PreservativesFemalehypersensitivityNasal CavitybusinessPulmonary Ventilationpersistent rhinitisTartrazine
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Tissue inflammatory biomarkers in chronic plaque psoriasis: Exploring lesional versus non‐lesional skin relative expression and possible clinical cor…

2019

AdultInflammationMalePlaque psoriasisPathologymedicine.medical_specialtybusiness.industryInflammationDermatologyMiddle AgedInflammatory biomarkersChronic diseaseChronic DiseasemedicineHumansPsoriasisFemalemedicine.symptombusinessBiomarkersAustralasian Journal of Dermatology
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Chronic inflammation causing spinal cord compression in human immunodeficiency virus infection

2008

BACKGROUND: The incidence of central nervous system involvement has increased in the setting of acquired immune deficiency syndrome (AIDS). Although rarely reported, spinal cord compression, in the setting of AIDS, has been associated with primary lymphoma or opportunistic infections. CASE REPORT: The authors describe the case of a young man who was admitted to our institution with rapid and progressive paraplegia. Imaging studies revealed an extramedullary lesion compressing the spinal cord spanning 3 thoracic levels. Surgical treatment was performed, and the compressing process completely excised. Histologic examination of the lesion showed a chronic inflammatory tissue with many necrotic…

AdultInflammationMaleSettore MED/27 - NeurochirurgiaChronic DiseaseAIDS Chronic inflammation spinal cord compressionHumansHIV InfectionsMagnetic Resonance ImagingSpinal Cord Compression
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