Search results for "CICE"
showing 10 items of 312 documents
The Eloquence of Publius Sulpicius Rufus and Gaius Aurelius Cotta in Cicero's Brutus
2018
The purpose of this chapter is to investigate the personalities of Publius Sulpicius Rufus and Gaius Aurelius Cotta, that illustrate the Roman eloquence at the beginning of the first century BC with particular regard to the wide section of the Ciceronian Brutus, the treatise in which they are protagonists of an intense confrontation in order to reflect on different styles of eloquence. On the other hand, a survey on the characteristics of their eloquence, conducted in the absence of direct evidence that provides objective feedback about their oratorical qualities, also makes possible to analyse the importance (and in some cases the indispensability) of Cicero’s opinion.
Reconsidering authorship in the Ciceronian corpus through computational authorship attribution
2019
In recent years, methods of computational authorship attribution have offered promising results for the reattribution of classical texts. We use and further develop these methods to verify the authorship of several texts belonging or related to the Ciceronian corpus: Rhetorica ad C. Herennium, De inventione, De optimo genere oratorum, and Commentariolum petitionis. We use two classifiers, Support Vector Machine and Convolutional Neural Network, of which the latter is more accurate except in regard to certain aspects of vocabulary. The most important of our results is that Commentariolum petitionis seems to be authored by Marcus Cicero, not by his brother Quintus. Negli ultimi anni metodi co…
Piantare alberi. Storie e modelli di crescita nel "Cato maior de senectute" di Cicerone
2019
Is the idea of “growing” and “development” useful to explain a work about senectus? The aim of this paper is to verify if Cicero’s Cato maior may offer a literary portrayal of “growth” in a double way: the biological one, with the human being intended as a mere individual, and the cultural one, relevant to human generations. The use of words and expressions from the rural context seems to enable Cicero to place the elderly in a justified relationship with the others ages of life, as he was rethinking the conflict of generations, because this opposition always talks about the ways every society conceives and describes itself.
Heat-induced action potential discharges in nociceptive primary sensory neurons of rats.
2009
Although several transducer molecules for noxious stimuli have been identified, little is known about the transformation of the resulting generator currents into action potentials (APs). Therefore we investigated the transformation process for stepped noxious heat stimuli (42-47 degrees C, 3-s duration) into membrane potential changes and subsequent AP discharges using the somata of acutely dissociated small dorsal root ganglion (DRG) neurons (diameteror=32.5 microm) of adult rats as a model for their own peripheral terminals. Three types of heat-induced membrane potential changes were differentiated: type 1, heat-induced AP discharges (approximately 37% of the neurons); type 2, heat-induce…
Sobre la filosofia de l’humanista valencià Joan Serra al De contemplatione amicicie. Notes a una traducció catalana
2013
Resum: Presentem la traducció catalana del De contemplatione amicicie, escrit per l’humanista valenciàJoan Serra l’any 1454. La traducció parteix de l’edició curada per Evencio Beltran de l’únic manuscritconegut: BNF ms Nat. lat. 8756. La translació s’acompanya d’una introducció historicofilosòficaarticulada al voltant de l’analogia fonamental de l’obra, a saber, la concòrdia absoluta de dos amicsés com la unió perfecta del cos i de l’ànima humana. S’hi analitzen les fonts fonamentals: Cicerói Pseudo-Agustí, i s’hi constata l’organització dual dels continguts del text, en tant que dedica elscapítols senars a la consideració de la unió del cos i l’ànima segons la filosofia natural, mentre qu…
Effects of Anandamide and Noxious Heat on Intracellular Calcium Concentration in Nociceptive DRG Neurons of Rats
2007
As an endogenous agonist at the cannabinoid receptor CB1 and the capsaicin-receptor TRPV1, anandamide may exert both anti- and pronociceptive actions. Therefore we studied the effects of anandamide and other activators of both receptors on changes in free cytosolic calcium ([Ca2+]i) in acutely dissociated small dorsal root ganglion neurons (diameter: ≤30 μm). Anandamide (10 μM) increased [Ca2+]iin 76% of the neurons. The EC50was 7.41 μM, the Hill slope was 2.15 ± 0.43 (mean ± SE). This increase was blocked by the competitive TRPV1-antagonist capsazepine (10 μM) and in Ca2+-free extracellular solution. Neither exclusion of voltage-gated sodium channels nor additional blockade of voltage-gate…
Effect of cooking and legume species upon calcium, iron and zinc uptake by Caco-2 cells
2006
Abstract An in vitro system, consisting of simulated gastrointestinal digestion and Caco-2 cell culture, was used to estimate the uptake of calcium, iron and zinc from white beans, chickpeas and lentils, and the effect of cooking upon uptake, with the ultimate aim of evaluating legumes as a dietary source of the aforementioned minerals. In raw products, differences were observed in the uptake percentages by Caco-2 cells of a same mineral from different legumes, although these were not related to the total mineral content. In the three elements studied, the highest uptake values corresponded to chickpeas. Traditional cooking significantly ( p 0.05 ) increased the uptake (%) of calcium, iron …
Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons.
1997
Noxious heat is able to activate heat-sensitive nociceptors in the skin very rapidly, but little is known about the mechanisms by which heat is transduced. We used the whole-cell patch-clamp technique to study the effects of noxious heat and capsaicin on freshly dissociated rat dorsal root ganglion neurons in vitro. Using temperatures between 41 degrees C and 53 degrees C, 8 of 19 small neurons (phior = 30 microm) exhibited a heat-evoked inward current. All heat-sensitive neurons tested were also capsaicin-sensitive. Moreover, the heat response tended to be enhanced after capsaicin (360 +/- 150 pA versus 125 +/- 45 pA, P0.1, n = 7). Two of five heat-insensitive neurons were excited by capsa…
DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain.
2022
While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summar…
Antihyperalgesic and analgesic properties of the N-methyl-d-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic …
2006
Abstract NMDA-receptors are a major target in the prevention and treatment of hyperalgesic pain states in neuropathic pain. However, previous studies revealed equivocal results depending on study design and efficacy parameters. We tested the analgesic (generalized reduction of generation and processing of nociceptive signalling) and anti-hyperalgesic (prevention of central sensitization) properties of the NMDA-receptor antagonist neramexane and the potassium channel opener flupirtine in the intradermal capsaicin injection model. Furthermore, we tested the effect on pain summation (wind up). Eighteen healthy subjects received either a single dose of neramexane (40 mg p.o.), flupirtine (100 m…