Search results for "CICE"

De Boethii Commentariis in Topica Ciceronis denuo edendis

1998

Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study

2018

Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming α-hemolysins that disrupt neuronal cell membranes. The hemolytic activity of P. acnes in cultured disc specimens obtained during routine therapeutic discectomies was assessed through incubation on sheep-blood agar. T…

Impact des modalités d'un exercice physique sur la neuroplasticité. Focus sur les sources de BDNF

2019

Physical exercise (EX) is recognized as the most potent non-pharmacological strategy to positively enhance brain health. From Human and animal studies there is a consensus to involve brain-derived neurotrophic factor (BDNF), a neurotrophin strongly expressed in response to EX and implicated in neuroplasticity mechanisms. Mainly expressed by neurons, BDNF is also expressed by endothelial and muscle cells. Largely sought during a physical effort, endothelium and skeletal muscle could be involved in positive effects induced by EX. Although there is a real consensus about BDNF and cerebral effect of EX, the typology of the better regimen of EX to enhance cerebral plasticity is not known. In thi…

Recensione a AA.VV., Le Brutus de Cicéron. Rhétorique, politique et histoire culturelle, sous la direction de Sophie Aubert-Baillot &Charles Guérin, …

2015

Recensione

Les effets du CICE sur l'emploi, les salaires et la R&D: une évaluation ex post

2017

Le Crédit d’Impôt pour la Compétitivité et l’Emploi est l’une des mesures phare du quinquennat de François Hollande. Mis en œuvre à partir de 2013, ce dispositif consiste en un crédit d’impôt d’un montant de 4 % de la masse salariale (6% en 2014) pour tous les salaires jusqu’à 2,5 Smic. Il s’agit d’un dispositif massif pour un coût budgétaire estimé à 11,2 milliards d’euros en 2013. L’objet de cette étude est de proposer une évaluation ex post des effets de ce dispositif sur l’emploi, les salaires et un ensemble d’autres variables caractérisant les réactions des entreprises au crédit d’impôt, notamment leurs marges et leurs comportement d’investissement. Elle repose sur l’exploitation d’un …

Valutazione e caratterizzazione bio-agronomica e qualitativa di gentipi di cece

2009

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

2007

Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impairment, motor disturbances and psychotropic effects resulting from the central actions of cannabinoids. We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in the peripheral nervous system of mice, preserving its expression in the CNS, and analyzed these genetically modified mice in preclinical models of inflammatory and neuropathic pain. The nociceptor-spec…

Complex regional pain syndrome–up-to-date

2017

The pathophysiology of complex regional pain syndromes includes inflammation and central reorganisation. The treatment should be adjusted to the prevailing pathophysiology including possible psychosocial factors.

Multiple mechanisms of secondary hyperalgesia

2000

Publisher Summary This chapter discusses the multiple mechanisms of secondary hyperalgesia. The chapter defines the minimal conditions of complexity that must be fulfilled by a model of plasticity of spinal nociceptive transmission in order to explain clinical and psychophysical observations in humans. Secondary hyperalgesia is characterized by a leftward shift of the stimulus-response function for noxious mechanical stimuli. In order to define the afferent pathways involved in inducing central sensitization and in mediating the hyperalgesia to noxious mechanical stimuli, several psychophysical experiments using selective nerve block techniques is performed. Secondary hyperalgesia is likely…

Within-session sensitization and between-session habituation: A robust physiological response to repetitive painful heat stimulation

2011

Habituation and sensitization are important behavioural responses to repeated exposure of painful stimuli. Whereas within-session response dynamics to nociceptive stimuli is well characterized, little is known about long-term behaviour due to repetitive nociceptive stimulation. We used a standardized longitudinal heat pain paradigm in 66 healthy participants, 21 patients with chronic low back pain and 22 patients with depression who received daily sessions of 60 suprathreshold heat stimuli (48 °C each) for eight consecutive days. All three groups showed the same response: Repeated painful stimulation over several days resulted in substantially decreased pain ratings to identical painful sti…