Search results for "CID"
showing 10 items of 19479 documents
Nanosystem for diagnosis and photothermal treatment of tumors
2022
The invention relates to a nanosystem for the diagnosis, image-guided treatment of tumors and monitoring of the tumor microenvironment. The nanosystem is a contrast agent comprising a polymer shell based on a hyaluronic acid nanogel, super-parameg-netic iron oxide nanoparticles (SPIONs) and carbon nanoparticles (CDs).
Formation of Si/SiO2 Luminescent Quantum Dots From Mesoporous Silicon by Sodium Tetraborate/Citric Acid Oxidation Treatment
2019
We propose a rapid, one-pot method to generate photoluminescent (PL) mesoporous silicon nanoparticles (PSiNPs). Typically, mesoporous silicon (meso-PSi) films, obtained by electrochemical etching of monocrystalline silicon substrates, do not display strong PL because the silicon nanocrystals (nc-Si) in the skeleton are generally too large to display quantum confinement effects. Here we describe an improved approach to form photoluminescent PSiNPs from meso-PSi by partial oxidation in aqueous sodium borate (borax) solutions. The borax solution acts to simultaneously oxidize the nc-Si surface and to partially dissolve the oxide product. This results in reduction of the size of the nc-Si core …
Composite Porous Alumina/CsH2PO4 membranes for H2/O2 room temperature fuel cell
2009
Oxidation-responsive and "clickable" poly(ethylene glycol) via copolymerization of 2-(methylthio)ethyl glycidyl ether
2016
Poly(ethylene glycol) (PEG) is a widely used biocompatible polymer. We describe a novel epoxide monomer with methyl-thioether moiety, 2-(methylthio)ethyl glycidyl ether (MTEGE), which enables the synthesis of well-defined thioether-functional poly(ethylene glycol). Random and block mPEG-b-PMTEGE copolymers (Mw/Mn = 1.05-1.17) were obtained via anionic ring opening polymerization (AROP) with molecular weights ranging from 5 600 to 12 000 g·mol-1. The statistical copolymerization of MTEGE with ethylene oxide results in a random microstructure (rEO = 0.92 ± 0.02 and rMTEG E = 1.06 ± 0.02), which was confirmed by in situ 1H NMR kinetic studies. The random copolymers are thermorespon…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…
MODIFICATION OF HYDROPHOBIC SURFACE WITH POLYASPARTAMIDE-BASED POLYCATIONS FOR BIOMEDICAL APPLICATION
2013
A convenient way for the achievement of polymer-based solid materials for specific biomedical applications is grafting the appropriate macromolecules onto the surfaces in order to confer them specific properties. To date many approaches have been used to covalently modify polymeric surfaces, and among them chemoselective coupling reactions, usually referred as “click” reactions, gained much attention thanks to simple procedure with high reaction rate under mild reaction conditions (at normal temperature and pressure) [1]. In particular, radical-initiated thiol-yne “photo-click” chemistry has been demonstrated as an effective way to functionalize efficiently surfaces. This method gives also …
Rhizoctonia solani AG5 and Its Offspring – Morphology and Sensitivity to Fungicides
2022
The objective of these studies was to identify differences and similarities within the progeny of Rhizoctonia solani AG5, which arose from basidiospores produced by the maternal strain ID23. The following characteristics were analyzed: appearance of the mycelium (color, structure, zonation, and presence of sclerotia), growth rate (at 10°C, 20°C, and 30°C), fungicide sensitivity, and hyphal structure. The mycelial color of R. solani AG5 ranged from white/cream to light and dark brown. The structure of the mycelium may be compacted or flattened with visible zoning or fluffy with dark brown sclerotia on the colony surface. Homokaryons and heterokaryons derived from homokaryons were analyzed by…
Incidence of oral sinus communications in 389 upper third molar extraction
2006
Podeu consultar la versió en castellà a http://hdl.handle.net/2445/117329
Evaluación preclínica de la toxicidad retiniana en la administración intravítrea de ácido docosahexaenoico en modelo experimental de conejo
2013
Objetivo: Evaluar la toxicidad retiniana a corto plazo de la administración intravítrea de una dosis única de ácido docosahexaenoico (DHA) en un modelo experimental de conejo. Material y métodos: Dieciséis conejos albinos Nueva Zelanda fueron seleccionados para este estudio toxicológico preclínico. Se prepararon seis concentraciones de DHA (Brudy Laboratorios, Barcelona, España): 10mg/50μl, 5mg/50μl, 2'5mg/50μl, 50μg/50μl, 25μg/50μl, 5μg/50μl. Cada concentración fue inyectada por vía pars plana en inyección intravítrea en el ojo derecho de dos conejos. La solución vehículo se inyectó en el ojo derecho de cuatro animales que se consideraron el grupo control. Se evaluó la seguridad retiniana …
Análisis y evaluación del riesgo de micotoxinas en café
2016
La población en general espera tener una alimentación cada vez más sana y segura, con alimentos nutritivos y asequibles. Desafortunadamente, antes durante y después de la cosecha, las materias primas y los productos procesados están sometidos a la contaminación por microorganismos y hongos y, en consecuencia, por sus metabolitos secundarios, las micotoxinas. El café es uno de estos productos. La presente tesis doctoral aborda nuevas técnicas analíticas para desvelar los contenidos de estas micotoxinas en café, y evalúa el “riesgo” que representa un producto tan fuertemente instaurado en la alimentación de numerosas sociedades a lo largo de todo el mundo. Entre las diferentes metodologías an…