Search results for "CIDI"

Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of In…

2021

Abstract Alzhèimer Disease (AD) is characterized by protein aggregates in the brain, including amyloid-beta (Aβ), a substrate for tissue transglutaminase (TG2). We assessed the effect of full native peptide of Aβ (1–42), the fragments (25–35 and 35–25) on TG2 expression and its isoforms (Long and Short) on mouse Olfactory Ensheathing Cells (OECs). The levels of cytoskeletal proteins, Vimentin and Glial Fibrillary Acid Protein, were also studied. The effect of the pre-treatment with Indicaxanthin on cell viability, total Reactive Oxygen Species, superoxide anion and apoptotic pathway activation was assessed. Since Nestin is co-expressed in pluripotent stem cells with cyclin D1, their levels …

Effect of treatment on sex offenders' recidivism: a meta-analysis

2017

Este meta-análisis tiene por objetivo medir el efecto del trata- miento en delincuentes sexuales. Tras una revisión sistemática de la litera- tura reciente, fueron seleccionados diecisiete estudios, contando con una muestra total de 6,681 delincuentes sexuales. Las tasas de reincidencia se- xual (13.12% vs. 17.94%), violenta –incluyendo la sexual– (25.5% vs. 29.1%) y general –cualquier tipo de reincidencia– (46.53% vs. 52.41%) de los delincuentes tratados fueron inferiores a las de los grupos control. Se evidenció la eficacia del tratamiento en la reducción de las tasas de reinci- dencia sexual (OR = .69; p< .05) y general (OR = .66; p < .05) de los sujetos tratados, pero no en las tasas de…

Cost-effectiveness of prison system development - comparison of the European countries

2020

The possibility to achieve successful resocialization of former prisoners back into society is an ongoing public debate, making it challenging for policymakers to implement prisoner rehabilitation programs capable of maintaining the public safety while allocating public funds in the most efficient way. The main aim of this study is to examine what is necessary for an investment in prison system development to be justified. The hypothesis of this study suggests that such investment can be cost-effective by reducing crime and recidivism rates in the long term by ensuring proper rehabilitation of prisoners. Accordingly, this research compares various European countries regarding their imprison…

Further Support for a Convergent Approach to Sex Offender Risk Assessment

2016

Links between adverse childhood experiences, psychopathological symptoms and recidivism risk in juvenile delinquents

2020

Research in the field of developmental psycho-criminology shows that conduct disorders and deviant behaviours are frequently associated with traumatic and adverse developmental experiences. Personality traits and psychopathological symptoms also increase the risk of criminality. However, the role of psychopathological symptoms in the relationship between adverse childhood experiences and offending has rarely been researched. The present study was designed to throw further light on these issues by analysing risk factors in a group of adolescents and young adults in a juvenile detention centre in southern Italy. Results support the idea that the accumulation of risk factors is a major factor…

Are validation scales useful for Detecting Deliberately Faked Personality Tests? A study in incarcerated populations

2012

Personality self-report questionnaires are frequently used in forensic settings to detect psychopathology, to predict recidivism, and to assess adaptability to life in prison. Although most personality questionnaires include validity or control scales, even with the scales most outcomes can be easily manipulated. The aim of this study is to analyze the utility of the control scales of the Situational Personality Questionnaire. A sample of 200 male prisoners was randomized into two groups. Both groups completed the SPQ as a part of the mandatory psychological assessment when they entered prison, and then again 8 months later. In time 2, one group received instructions to falsify the results …

The influence of treatment programmes on the recidivism of juvenile and adult offenders: An european meta-analytic review

1999

Abstract Meta-analyses have examined the effectiveness of different treatment techniques on delin-quent and criminal behaviour in America and Europe. In one of the last meta-analyses, that integrated the results of programmes applied in European countries (Redondo, Garrido, and Sanchez-Meca, 1997), the global effect size obtained for all treatment and effectiveness measures (Psychological factors, education, etc.) was d = 0.3039 (r = 0.15). In general, it muld be interpreted that treatment groups surpassed controls by 15%, On this work, the results of a meta-analysis to determine which treatments are more effective in reducing on recidivism rates are presented. A total of 32 European studie…

Biodiversità associata ai reef a vermeti: effetti dell'acidificazione sulla malacofauna

2014

La continua e prevista Acidificazione degli Oceani (AO) potrebbe rappresentare un ampio fattore di stress per molti organismi marini, soprattutto calcificanti. La principale causa dell’acidificazione degli oceani è legata all’aumento della CO₂ antropogenica. I Reef a Vermeti, a causa della loro eterogeneità, la locazione intertidale e gli alti livelli di biodiversità che supportano, rappresentano un Habitat chiave in Mediterraneo. Attraverso un esperimento di trapianto sono state valutate possibili variazioni in composizione e struttura del popolamento a molluschi associato lungo un gradiente naturale di pH.

The conservation and diversity of ascidian cells and molecules involved in the inflammatory reaction: The Ciona robusta model

2021

Ascidians are marine invertebrate chordates belonging to the earliest branch (Tunicata) in the chordate phylum, therefore, they are of interest for studying the evolution of immune systems. Due to the known genome, the non-colonial Ciona robusta, previously considered to be C. intestinalis type A, is a model species for the study of inflammatory response. The internal defense of ascidians mainly relies on hemocytes circulating in the hemolymph and pharynx. Hemocytes can be in vivo challenged by LPS injection and various granulocyte and vacuolated cell populations differentiated to produce and release inflammatory factors. Molecular biology and gene expression studies revealed complex defens…

Nitric oxide synthesis is related to astroglial cell cycle in the mouse retina via p53 gene regulation

2009

Purpose To analyze the influence of p53 gene in retinal astrocytes morphology and function. Methods Adult mice of the strain C57BL/6 were distributed into two groups: 1) wild type TP53, as the controls (cp53; n=20) and 2) mice with an extra copy of p53 (sp53; n=22). Both eyeballs were enucleated, after death by ether narcosis, to obtain the retinas. Right retinas were frozen (-85oC) until processing to assess nitric oxide (NO) synthesis. Left retinas were obtained and proccesed to perform immunohistochemical localization of the glial fibrillary acidic protein (GFAP). Data are expressed as the mean ± SD. Statistical analysis was carried out using Student’s t-test. Confidence interval was tak…