Search results for "CIDI"
showing 10 items of 778 documents
Macrophage protease-activated receptor 2 regulates fetal liver erythropoiesis in mice.
2020
AbstractDeficiencies in many coagulation factors and protease-activated receptors (PARs) affect embryonic development. We describe a defect in definitive erythropoiesis in PAR2-deficient mice. Embryonic PAR2 deficiency increases embryonic death associated with variably severe anemia in comparison with PAR2-expressing embryos. PAR2-deficient fetal livers display reduced macrophage densities, erythroblastic island areas, and messenger RNA expression levels of markers for erythropoiesis and macrophages. Coagulation factor synthesis in the liver coincides with expanding fetal liver hematopoiesis during midgestation, and embryonic factor VII (FVII) deficiency impairs liver macrophage development…
Immunohistopathology in Diagnostic Neuropathology
1983
Within the field of surgical pathology, immunohistochemistry is now frequently applied to the morphological diagnosis of lymphomas (11), certain carcinomas and other selected types of tumor (12). In neuropathology, the study of neuro-oncological and non-neoplastic diseases may also receive diagnostic support from performing immunohistological techniques, which encompass immunofluorescent and immunoperoxidase methods. The following report represents a survey of our experience in this recently developed field of diagnostic neuropathology.
Oral paracoccidioidomycosis in a non-endemic region from Brazil: A short case series.
2019
Background Although the paracoccidioidomycosis (PCM) is endemic in Brazil, the occurrence in most states from the North and Northeastern Brazil is very unusual. The aim of this study was to evaluate the clinicopathologic features of a case series of oral PCM in a non-endemic region from Brazil (Northeastern region), discussing the clinical and histopathological differential diagnoses of the oral manifestations of the disease. Material and methods Between 2000 and 2017, all cases of oral PCM were retrieved from the Oral Pathology Laboratory, Universidade Federal de Pernambuco, located at Northeastern Brazil. Clinical data, such as age, gender, origin, occupation, site, symptoms, time of comp…
Actuarial Risk Assessment of Sexual Offenders
2016
A Brief History of Sexual Offender Risk Assessment
2016
The assessment of risk of further offending behavior by adult sexual perpetrators has come a long way since the early 1900s. From risk estimations based on clinical observation and environmental changes in the 1920s, anthropological and longitudinal studies of juvenile offenders in the 1930s, the examination of psychoneurotic patients in the 1940s to the application of actuarial prediction to clinical assessment in the 1950s, researchers and practitioners have sought to identify valid and reliable measures of recidivism risk in sexual offenders. The emphasis in risk prediction slowly changed following Meehl’s (1954) seminal contributions to the clinical-statistical debate which introduced t…
Proteomic analysis of the organic matrix of the abalone Haliotis asinina calcified shell.
2010
Abstract Background The formation of the molluscan shell is regulated to a large extent by a matrix of extracellular macromolecules that are secreted by the shell forming tissue, the mantle. This so called "calcifying matrix" is a complex mixture of proteins and glycoproteins that is assembled and occluded within the mineral phase during the calcification process. While the importance of the calcifying matrix to shell formation has long been appreciated, most of its protein components remain uncharacterised. Results Recent expressed sequence tag (EST) investigations of the mantle tissue from the tropical abalone (Haliotis asinina) provide an opportunity to further characterise the proteins …
El fomento de la mediación y de otros medios alternativos de justicia (también) en relación con la sustracción internacional de menores en Europa
2021
El decidido fomento de la mediación y de otros instrumentos MASC en el ámbito del Derecho de familia internacional constituye una constante, en los últimos tiempos, en el panorama comparado internacional. También en relación con aquellas disputas que involucran a menores. La UE no es ajena a este proceso y contribuye decididamente a éste. Aunque persisten dudas sobre la virtualidad real de estos mecanismos en la práctica diaria internacional.
El consentimiento informado de los menores de edad en el ámbito sanitario
2021
: El consentimiento informado aparece como un derecho de todo paciente a decidir en el ámbito sanitario. En este marco, es necesario determinar si los menores de edad han de ejercitar este derecho o si, por el contrario, precisan de la intervención de un tercero para llevarlo a cabo. A este respecto, nuestra legislación actual reconoce, con carácter general, el derecho a decidir de este colectivo. No obstante, en ocasiones pueden producirse limitaciones a su ejercicio motivadas bien por la ausencia de capacidad real, bien por el principio de interés superior. En definitiva, se trata de alcanzar el mayor beneficio para los menores de edad en el campo de la salud, evitando que se produzcan pe…
Primeras consideraciones a la Ley Orga?nica 3/2021, de 24 de marzo, de regulación de la eutanasia. el reconocimiento de un nuevo derecho
2021
The aim of this paper is to carry out a brief study of the recent Organic Law 3/2021, of March 24, on the regulation of euthanasia (BOE. March 25, 2021) approved in Spain, from a constitutional perspective, highlighting its main aspects. The matter under study is not exempt from controversy because it covers legal, medical and ethical considerations of great complexity.
Efficacy of an internet-based psychological intervention for problem gambling and gambling disorder: study protocol for a randomized controlled trial
2021
Gambling Disorder is a prevalent non-substance use disorder, which contrasts with the low number of people requesting treatment. Information and Communication Technologies (ICT) could help to enhance the dissemination of evidence-based treatments and considerably reduce the costs. The current study seeks to assess the efficacy of an online psychological intervention for people suffering from gambling problems in Spain. The proposed study will be a two-arm, parallel-group, randomized controlled trial. A total of 134 participants (problem and pathological gamblers) will be randomly allocated to a waiting list control group (N = 67) or an intervention group (N = 67). The intervention program i…