Search results for "CIG"

Bec-pla, Espátula común (VER0000071)

Altres noms vulgars: Eurasian spoonbill (Anglès), Spatule blanche (Francès), Löffler (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 11-1 Puçol Invierno leucorodia _

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

2018

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult s…

Sesquiterpene lactones from Artemisia species

1993

Abstract The aerial parts of Artemisia spicigera yielded two new eudesmanolides as well as three known ones. The aerial parts of Artemisia verlotiorum yielded four known germacranolides and two known eudesmanolides.

Perceived stress and smoking across 41 countries: A global perspective across Europe, Africa, Asia and the Americas

2017

Within recent years, there has been a seismic shift in smoking rates from high-income to low- and middle-income countries (LMICs). Evidence indicates that perceived stress may comprise a barrier for smoking cessation, but little is known about the association of perceived stress and smoking in LMICs. We conducted a cross-sectional, community-based study comprising 217,561 people [mean age 38.5 (SD = 16.1) years, 49.4% males]. A perceived stress score [range 2 (lowest-stress) 10 (highest-stress)] was computed from the Perceived Stress Scale. Multivariable logistic regression analyses were conducted. In the overall sample, a one-unit increase in perceived-stress resulted in a 5% increased odd…

Hajłasz–Sobolev imbedding and extension

2011

Abstract The author establishes some geometric criteria for a Hajlasz–Sobolev M ˙ ball s , p -extension (resp. M ˙ ball s , p -imbedding) domain of R n with n ⩾ 2 , s ∈ ( 0 , 1 ] and p ∈ [ n / s , ∞ ] (resp. p ∈ ( n / s , ∞ ] ). In particular, the author proves that a bounded finitely connected planar domain Ω is a weak α -cigar domain with α ∈ ( 0 , 1 ) if and only if F ˙ p , ∞ s ( R 2 ) | Ω = M ˙ ball s , p ( Ω ) for some/all s ∈ [ α , 1 ) and p = ( 2 − α ) / ( s − α ) , where F ˙ p , ∞ s ( R 2 ) | Ω denotes the restriction of the Triebel–Lizorkin space F ˙ p , ∞ s ( R 2 ) on Ω .

The Health Risks of Electronic Cigarettes Use in Adolescents

2020

The evidence to date suggests that vaping is not a safe alternative to smoking tobacco. This, coupled with the worrying trend of young nonsmokers being attracted to vaping, raises fears of yet another generation suffering from chronic lung disease and other acute and chronic health conditions. Finally, due to the insufficient regulations in several countries, up-to-date data on the prevalence of e-cigarette use and studies on the health's implications of their use are urgently needed to inform policy at a national and international level (ie, European Union). Pediatricians are typically on the front line for identifying emerging risks for children and adolescents ; therefore, they may effec…

Human HSP10 variants downregulation after cigarette smoke extract exposure in lung cells

2009

The impact of cigarette-smoke stress (a form of oxidative stress) on human lung fibroblasts and epithelial cells, particularly its effect on Hsp10 expression, has not been characterized despite the fact that a role for mitochondrial chaperonins in the development of lung diseases, ranging from chronic obstructive pulmonary disease to bronchial carcinogenesis, has been suggested (1). We studied the effects of non-lethal doses of cigarette smoke extract (CSE) on the expression of Hsp10 in human lung fibroblasts (HFL-1 line) and epithelial cells (16HBE line). Proteomics was carried out using 2D-IPG, silver stain, western blotting, and mass-spectrometry; mRNA was measured by RT-PCR. Database se…

Dažādu smēķēšanas veidu izvēles raksturojums Rīgas izglītības iestādēs

2021

Par maģistra darba mērķi izvirzījām noskaidrot, kādi ir aktuālie smēķēšanas ieradumi Rīgas izglītības iestādēs. Par maģistra darba uzdevumiem izvirzījām noskaidrot, kādas smēķēšanas metodes izvēlas skolnieki un studenti no 15 gadu vecuma, kā viņi izturas pret esošajiem smēķēšanas ierobežojumiem, kāda ir attieksme pret jaunajām tabakas lietošanas iespējām un kas varētu veicināt šī negatīvā ieraduma atmešanu, lai uzlabotu Latvijas iedzīvotāju kopējo veselības līmeni. Pētījumā noskaidrojām, ka jaunieši uzsāk smēķēšanu 10-20 gadu vecumā, pirmajā smēķēšanas reizē izvēloties cigaretes. Svarīgākie smēķēšanu veicinošie faktori ir problēmas mācībās/studijās, emocionālās problēmas un spriedze. Vairāk…

The impact of cigarette smoking on the health of descendants

2012

This paper presents a review of the literature on the effects of cigarette smoking on the health of descendants and the possible mechanisms that lead to them. The evidence of the effects of prenatal cigarette smoke exposure on neonatal morbidity is clear. A number of birth defects have their incidence raised by maternal cigarette smoking during pregnancy. Prenatal smoke exposure also increases the risk of infant irritability, inattention, decreased response to inanimate auditory stimuli and hypertonia. In addition, the prevalence of obesity in preschool children is higher if the mother smoked during pregnancy, as well as the presence of male or female subfertility/infertility in adult life.…

Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages

2022

Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investig…