Search results for "CIT"
showing 10 items of 22474 documents
Latvijas Nacionālās bibliotēkas Bērnu literatūras centra aktivitāšu atrodamība elektroniskajā vidē
2019
Maģistra darba “Latvijas Nacionālās bibliotēkas Bērnu literatūras centra aktivitāšu atrodamība elektroniskajā vidē” mērķis ir noskaidrot, kāda ir Latvijas Nacionālās bibliotēkas Bērnu literatūras centra aktivitāšu atrodamība ar meklēšanas rīkiem un kāda ir atrasto publikāciju kvalitāte. Lai sasniegtu mērķi, tika izvirzīti vairāki uzdevumi, kuri veiksmīgi tika īstenoti. Maģistra darbā izmantota jaukta pētījuma stratēģija. Datu ieguvei tiek izmantotas divas pētniecības metodes – intervija un kontentanalīze. Pētījuma teorētisko bāzi veido aksioloģija un bibliotēku mārketings. Metodes palīdz apstrādāt datus par Bērnu literatūras centra aktivitāšu atrodamību tīmeklī un vērtību sabiedrībā. Pētīju…
Žurnālistu līdzdalība kriminālprocesā. Galvenie problēmjautājumi
2018
Sabiedrība par noziedzīgiem nodarījumiem bieži vien uzzina no žurnālistiem. Patlaban notiek aktīvs darbs pie žurnālistu pilnvaru paplašināšanas, lai vairotu demokrātiskas sabiedrības tiesības uzraudzīt kriminālprocesu likumību. Tomēr publicitāte kriminālprocesa laikā ir saistīta ar dažādiem riskiem. Persona var tikt apmelota, pazemota, tai var tikt ievērojami apgrūtināta reintegrācijas iespēja sabiedrībā. Situāciju sarežģī personas brīvības ierobežošana. Tas viss attiecas arī uz personas tuviniekiem. Tāpēc aktuāls jautājums ir procesuālo garantiju radīšana, kas mazinātu negatīvas publicitātes ietekmi. Autors piedāvā likuma grozījumus, kas paredzētu konkretizēt sabiedrības leģitīmas interese…
Determinazione del grado di fitotossicità degli insetticidi impiegati in trattamenti endoterapici su palma delle Canarie
2009
Vortex dynamics in rotating counterflow and plane Couette and Poiseuille turbulence in superfluid Helium
2008
An equation previously proposed to describe the evolution of vortex line density in rotating counterflow turbulent tangles in superfluid helium is generalized to incorporate nonvanishing barycentric velocity and velocity gradients. Our generalization is compared with an analogous approach proposed by Lipniacki, and with experimental results by Swanson et al. in rotating counterflow, and it is used to evaluate the vortex density in plane Couette and Poiseuille flows of superfluid helium.
Problem solving e metacognizione. L’uso didattico del prompt per sviluppare strategie di problem solving nei futuri maestri
2015
Si presentano i risultati di una ricerca che ha coinvolto in totale 235 studenti del corso di Laurea in Scienze della Formazione Primaria dell’Università di Palermo. Con la ricerca si è inteso individuare le metodologie di sostegno atte a promuovere nei futuri maestri da una parte la capacità di identificare e affrontare situazioni scolastiche problematiche in modo adeguato; dall’altra la capacità di riflettere metacognitivamente sul processo di risoluzione del problema. La ricerca costituisce un esempio di come si possa sviluppare nei futuri insegnanti in formazione quell’insieme di abilità cognitive e metacognitive che confluiscono nella capacità di identificare e risolvere situazioni edu…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
La necesaria rehabilitación del sistema representativo en las propuestas de reforma democrática
2010
In the debates on deliberative democracy it’s a common idea that the defenders of this theory argue for the direct participation of the citizens in the political issues and for the transformation of our current representative devices. However, in this work I argue that this conception is misguided, and that it’s the minority who defends the direct participation. The majority of the writers acknowledges the necessity of a representative device, although based on different premises to the liberal system. The deliberative democracy supports a responsible and compromised citizenship, against the model of self interested citizenship.<br><br>En los debates sobre la democracia delibera…
Identification of the Jπ = 1− state in 218Ra populated via α decay of 222Th
2016
The α decay of 222Th populating the low-lying J π = 3− state, and also a proposed 1− state, in 218Ra has been observed. The observations suggest an excitation energy of 853 keV for the 1− state, which is 60 keV above the 3− state. The hindrance factors of these α decays give a possible boundary to the region of ground-state octupole deformation in the light-actinide nuclei. The relative positions of the J π = 1− and 3− states suggest they are produced by an octupole-vibrational mechanism, as opposed to α clustering or rotations of a reflection-asymmetric octupole-deformed shape. peerReviewed
Generalized wave propagation problems and discrete exterior calculus
2018
We introduce a general class of second-order boundary value problems unifying application areas such as acoustics, electromagnetism, elastodynamics, quantum mechanics, and so on, into a single framework. This also enables us to solve wave propagation problems very efficiently with a single software system. The solution method precisely follows the conservation laws in finite-dimensional systems, whereas the constitutive relations are imposed approximately. We employ discrete exterior calculus for the spatial discretization, use natural crystal structures for three-dimensional meshing, and derive a “discrete Hodge” adapted to harmonic wave. The numerical experiments indicate that the cumulat…