Search results for "CKM"
showing 10 items of 51 documents
Investigating the Effects of Differential Learning on Golfers’ Pitching Performance as a Function of Handicap
2022
Traditionally, golf instruction has been oriented toward imitation of role models, guided by errors that surround a channel of supposedly correct repetition. Recent motor learning approaches relying on the dynamics of living systems suggest the inclusion of additional noise during practice for supporting players’ movement exploration and improving adaptability that in consequence will lead to increased performance. While the effectiveness of this approach has now been demonstrated in many sports, research exploring the effects of differential learning (DL) in golf is scarce, especially when considering different shot distances and players with various handicap levels. Therefore, the p…
Relationship Between Neotectonics And Fluid Escaping In The Northern Sicilian Continental Margin
2011
New exploration in the marine environments has revealed that the fluid escape structures are often associated with neotectonic elements and are aligned along the same direction. Sometimes is observed the migration of fluid along fault planes to the sea floor as gas venting (Forrest et al., 2005). This paper aims to recognize and to classify the different types of structures associated with fluid seepage, particularly those that develop along alignments coinciding with or parallel to the neotectonic lineaments, in order to assess the interactions between tectonics and fluid circulation. The study area extends, from west to east, from the Gulf of Castellammare to the Gulf of Termini (offshore…
New method for calculating electromagnetic effects in semileptonic beta-decays of mesons
2020
We construct several classes of hadronic matrix elements and relate them to the low-energy constants in Chiral Perturbation Theory that describe the electromagnetic effects in the semileptonic beta decay of the pion and the kaon. We propose to calculate them using lattice QCD, and argue that such a calculation will make an immediate impact to a number of interesting topics at the precision frontier, including the outstanding anomalies in $|V_{us}|$ and the top-row Cabibbo-Kobayashi-Maskawa matrix unitarity.
First-line (1L) nivolumab (NIVO) plus chemotherapy (chemo) versus chemo in advanced gastric cancer/gastroesophageal junction cancer/esophageal adenoc…
2021
4002 Background: CheckMate 649 is the largest randomized, global phase 3 study of 1L programmed death (PD)-1 inhibitor–based therapy in GC/GEJC/EAC. 1L NIVO + chemo demonstrated superior overall survival (OS) vs chemo, with progression-free survival (PFS) benefit and an acceptable safety profile in pts whose tumors expressed PD-ligand (L)1 at combined positive score (CPS) ≥ 5 and ≥ 1, and in all randomized pts (Moehler et al. Ann Oncol 2020). We report additional data for all randomized pts. Methods: Eligible pts had previously untreated, unresectable advanced or metastatic GC/GEJC/EAC. Known HER2-positive pts were excluded. Pts were randomized to receive NIVO (360 mg Q3W or 240 mg Q2W) + …
Adjuvant nivolumab (NIVO) in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiotherapy (CRT): Expande…
2021
4003 Background: In CheckMate 577 (NCT02743494), NIVO demonstrated a significant and clinically meaningful improvement in disease-free survival (DFS; primary endpoint) vs placebo (PBO) and was well tolerated in patients (pts) with resected (R0) stage II/III EC/GEJC who received neoadjuvant CRT and had residual pathologic disease. Median DFS doubled with NIVO vs PBO (22.4 vs 11.0 months; HR 0.69; 96.4% CI 0.56–0.86; P = 0.0003). Serious treatment-related adverse events (TRAEs) and TRAEs leading to discontinuation were reported for < 10% of pts with NIVO and 3% with PBO. Methods: Pts were randomized 2:1 to NIVO 240 mg or PBO Q2W for 16 weeks, followed by NIVO 480 mg or PBO Q4W. Here, we p…
1381P Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiotherapy (CRT): 14-month…
2021
LBA9_PR Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer (EC/GEJC) following neoadjuvant chemoradiation therapy (CRT): F…
2020
Measurement of matter-antimatter differences in beauty baryon decays
2017
Differences in the behaviour of matter and antimatter have been observed in $K$ and $B$ meson decays, but not yet in any baryon decay. Such differences are associated with the non-invariance of fundamental interactions under the combined charge-conjugation and parity transformations, known as $C\!P$ violation. Using data from the LHCb experiment at the Large Hadron Collider, a search is made for $C\!P$-violating asymmetries in the decay angle distributions of $\Lambda^0_b$ baryons decaying to $p\pi^-\pi^+\pi^-$ and $p\pi^-K^+K^-$ final states. These four-body hadronic decays are a promising place to search for sources of $C\!P$ violation both within and beyond the Standard Model of particle…
A possible evolutionary model of “aligned pockmarks”
2014
A Comprehensive Mechanism Reproducing the Mass and Mixing Parameters of Quarks and Leptons
2013
It is shown that if, from the starting point of a universal rank-one mass matrix long favored by phenomenologists, one adds the assumption that it rotates (changes its orientation in generation space) with changing scale, one can reproduce, in terms of only six real parameters, all the 16 mass ratios and mixing parameters of quarks and leptons. Of these 16 quantities so reproduced, 10 for which data exist for direct comparison (i.e. the CKM elements including the CP-violating phase, the angles theta(12), theta(13), theta(23) in nu-oscillation, and the masses m(c), m(mu), m(e)) agree well with experiment, mostly to within experimental errors; four others (m(s), m(u), m(d), m(nu 2)), the expe…