Search results for "CLADES"
showing 10 items of 33 documents
Parallel diversifications of Cremastosperma and mosannona (annonaceae), tropical rainforest trees tracking neogene upheaval of South America
2018
Much of the immense present day biological diversity of Neotropical rainforests originated from the Miocene onwards, a period of geological and ecological upheaval in South America. We assess the impact of the Andean orogeny, drainage of Lake Pebas and closure of the Panama isthmus on two clades of tropical trees ( Cremastosperma , ca 31 spp.; and Mosannona , ca 14 spp.; both Annonaceae). Phylogenetic inference revealed similar patterns of geographically restricted clades and molecular dating showed diversifications in the different areas occurred in parallel, with timing consistent with Andean vicariance and Central American geodispersal. Ecological niche modelling approaches show phyloge…
L'oposició universitària al franquisme : València 1939-1975
1996
La obra "L'oposició universitària al franquisme : València 1939-1975", fue editada en el curso 1995-1996 por DISE, revista de la Universidad de Valencia. La dirección y texto es de Benito Sanz Díaz, y la dirección técnica de Mª Ferranda Martí Campoy, directora de DISE. Se distribuyó en 9 fascículos a través de citada revista, y se hizo una edición en forma de libro. Los fascículos se dividían en texto principal, y unas separatas de colaboraciones. La investigación recoge las distintas épocas de oposición a la dictadura en la Universidad de Valencia. Analiza la caída del sindicato falangista –SEU- y la aparición del Sindicato Democrático de Estudiantes de Valencia –SDEUV-, la creación del Pa…
Patterns of differentiation in extraosseous Ewing's sarcoma cells. An in vitro study.
1994
BACKGROUND In vitro, tissue culture-associated differentiation assays have facilitated the identification of multiple tumor-cell types. METHODS We have investigated the capability of differentiation of three extraosseous Ewing's sarcoma cell lines toward a neural and muscular direction by in vitro stimulation with dibutyryl cyclic adenosine-monophosphate (db cAMP) and 5-azacytidine, respectively. RESULTS Elongation of cytoplasmic processes and increase of neural markers chromogranin, S-100 protein, and glial fibrillary acidic protein were observed after db cAMP treatment of these lines and neurosecretory granules as well as myelin figures were demonstrated ultrastructurally. These results s…
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patient…
1999
Objective To study the localization and cell type–specific expression of collagenase 3 messenger RNA (mRNA) in the synovial membrane, its regulation in primary synovial fibroblasts, and the correlation with systemic markers of inflammation and radiographic damage in rheumatoid arthritis (RA). Methods The expression of collagenase 3 mRNA was characterized by Northern blot analysis, reverse transcriptase–polymerase chain reaction, and in situ hybridization. Immunohistochemical detection of cell type–specific antigens was used in combination with in situ hybridization of collagenase 3 mRNA to characterize the cellular origin of collagenase 3 mRNA expression. Results Collagenase 3 mRNA was dete…
Fast extension but little exhumation: the Vari detachment in the Cyclades, Greece
2003
Markedly different cooling histories for the hanging- and footwall of the Vari detachment on Syros and Tinos islands, Greece, are revealed by zircon and apatite fission-track data. The Vari/Akrotiri unit in the hangingwall cooled slowly at rates of 5–15 °C Myr−1 since Late Cretaceous times. Samples from the Cycladic blueschist unit in the footwall of the detachment on Tinos Island have a mean zircon fission-track age of 10.0±1.0 Ma, which together with a published mean apatite fission-track age of 9.4±0.5 Ma indicates rapid cooling at rates of at least ∼60 °C Myr−1. We derive a minimum slip rate of ∼6.5 km Myr−1 and a displacement of <∼20 km and propose that the development of the detach…
Miocene high-pressure metamorphism in the Cyclades and Crete, Aegean Sea, Greece: Evidence for large-magnitude displacement on the Cretan detachment
2001
The Cyclades in the backarc region of the present Hellenic subduction zone are known for widespread Late Cretaceous to Eocene high-pressure metamorphism in the Cycladic blueschist unit. We report 40 Ar/ 39 Ar and Rb/Sr phengite ages of 24–21 Ma for high- pressure metamorphism (8–10 kbar, 350–400 °C) in the lowest tectonic unit in the Cyclades, the Basal unit, which structurally underlies the Cycladic blueschist unit. The Basal unit is correlated with the Tripolitza unit of the External Hellenides in the forearc region of the Hellenic subduction zone. The Tripolitza unit is unmetamorphosed on Crete, where it is separated from the underlying high-pressure (8–10 kbar, 300–400 °C) Plattenkalk a…
Structural analysis of a complex nappe sequence and late-orogenic basins from the Aegean Island of Samos, Greece
1999
The island of Samos in the Aegean Sea exposes high-pressure metamorphic rocks of the Cycladic blueschist unit which are sandwiched between the mildly blueschist-facies Kerketas nappe below and the overlying non-metamorphic Kallithea nappe. Structural and metamorphic analysis shows that deformation can generally be divided into four main stages: (1) Eocene and earliest Oligocene 0ESE‐WNW-oriented nappe stacking (D1 and D2) associated with blueschist- and transitional blueschist‐ greenschist-facies metamorphism (M1 and M2). D2 caused emplacement of the blueschist unit onto the Kerketas nappe indicating that thrusting occurred during decompression. (2) A subsequent history of Oligocene and Mio…
Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of…
2004
The expression level of neuronal nitric oxide synthase (nNOS) can vary depending on the (patho)physiological conditions. Here we document a marked induction of nNOS mRNA, protein, and total NO production in response to dibutyryl cyclic AMP (db-cAMP) in human A673 neuroepithelial cells. However, the upregulation of nNOS was associated with a decreased level of production of bioactive NO and by an increase in the level of generation of reactive oxygen species (ROS). ROS production could be prevented by the NOS inhibitor L-NAME, suggesting nNOS itself is involved in ROS generation. Sepiapterin supplementation of db-cAMP-treated A673 cells could restore full bioactive NO production, most likely…
Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 i…
1989
We present data showing that the major phenobarbital inducible cytochromes P-450 (cytochrome P-450IIB1 and cytochrome P-450IIB2) were phosphorylated in intact hepatocytes. This phosphorylation was greatly increased by the cAMP derivatives N6-dibutyryl-cAMP and 8-thiomethyl-cAMP mediated by a cAMP-dependent protein kinase. Most importantly the phosphorylation status of cytochromes P-450 was shown to change in the hepatocytes after treatment with glucagon, which is known to increase the level of cAMP in hepatocytes. The observed impact of the hormone glucagon on the phosphorylation of distinct cytochrome P-450 forms in intact hepatocytes reveals the possibility that the enzyme activity of cyt…
Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.
2005
Even before the first vertebrates appeared on our planet, the aryl hydrocarbon receptor ( AHR ) gene was present to carry out one or more critical life functions. The vertebrate AHR then evolved to take on functions of detecting and responding to certain classes of environmental toxicants. These environmental pollutants include polycyclic aromatic hydrocarbons (e.g., benzo[ a ]pyrene), polyhalogenated hydrocarbons, dibenzofurans, and the most potent small-molecular-weight toxicant known, 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD or dioxin). After binding of these ligands, the activated AHR translocates rapidly from the cytosol to the nucleus, where it forms a heterodimer with aryl hydroc…