Search results for "CLL"
showing 10 items of 73 documents
Conceptual design of the main Ancillary Systems of the ITER Water Cooled Lithium Lead Test Blanket System
2021
Abstract The Water Cooled Lithium Lead Test Blanket System (WCLL TBS) is one of the EU Test Blanket Systems candidate for being installed and operated in ITER. In view of its Conceptual Design Review by F4E and ITER Organization (IO), planned for mid-September 2020, several technical activities have been performed in the areas of WCLL TBS Ancillary Systems design. In this article the outcomes of the conceptual design phase of the four main Ancillary Systems of WCLL TBS, namely the Water Cooling System (WCS), the Coolant Purification System (CPS), the PbLi loop and the Tritium Extraction System (TES), are reported and critically discussed. In particular, for each Ancillary System hereafter a…
On the effects of the Double-Walled Tubes lay-out on the DEMO WCLL breeding blanket module thermal behavior
2019
Abstract The EU-DEMO Water-Cooled Lithium Lead Breeding Blanket (WCLL BB) concept foresees liquid Pb-15.7Li eutectic alloy as breeder and neutron multiplier, whereas pressurized subcooled water as coolant, with operative conditions typical of the PWR fission reactors (temperature in the range of 295–328 °C and pressure of 15.5 MPa). The cooling down of the BB is guaranteed by means of two separated cooling circuits: the one consisted in square channels housed within the complex of Side Walls and First Wall, and the one composed of a set of Double-Walled Tubes (DWTs) submerged in the Breeding Zone (BZ) and deputed to remove heat power therein generated. A parametric thermal study has been ca…
Thermo-mechanical analyses and ways of optimization of the helium cooled DEMO First Wall under RCC-MRx rules
2017
Abstract The EUROfusion Consortium develops a design of a fusion power demonstrator plant (DEMO) in the framework of the European “Horizon 2020” innovation and research program. One of the key components in the fusion reactor is the Breeding Blanket (BB) surrounding the plasma, ensuring tritium self-sufficiency, heat removal for conversion into electricity, and neutron shielding. Among the 4 candidates for the DEMO BB, 2 of them use helium as coolant (HCPB, HCLL), and another one (DCLL) uses helium to cool down the First Wall (FW) only. Due to uncertainties regarding the plasma Heat Flux (HF) load the DEMO BB integrated FW will have to cope with, a set of sensitive thermal and stress analys…
Associations of ofatumumab exposure and treatment outcomes in patients with untreated CLL receiving chemoimmunotherapy
2016
Relationships between patient characteristics, ofatumumab pharmacokinetics, and treatment outcomes were investigated in this phase 2 trial of ofatumumab plus fludarabine and cyclophosphamide (FC) in untreated chronic lymphocytic leukemia. Patients were randomized 1:1 to receive 500 or 1000 mg ofatumumab (Cycle 1; 300 mg) plus FC every 4 weeks for six cycles. Median C(max) and C(trough) values were similar at Cycle 1 regardless of the ultimate clinical outcome. At later doses, these values were higher for patients with complete response (CR) than for other patients. Higher C(max) and C(trough) values at Cycles 3 and 6 were significantly associated with an increased likelihood of CR, whereas …
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
2013
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 × 10-14), 18q21.33 (BCL2, P = 7.76 × 10-11), 11p15.5 (C11orf21, P = 2.15 × 10 -10), 4q25 (LEF1, P = 4.24 × 10-10), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 × 10-9), 9p21.3 (CDKN2B-AS1, P = 1.27 × 10…
Thermo-Mechanical Analysis and Design Update of the Top Cap Region of the DEMO Water-Cooled Lithium Lead Central Outboard Blanket Segment
2022
Within the framework of the EUROfusion research and development activities, the Water-Cooled Lithium Lead (WCLL) Breeding Blanket (BB) is one of the two candidates to be chosen as the driver blanket for the European DEMO nuclear fusion reactor. Hence, an intense research work is currently ongoing throughout the EU to develop a robust conceptual design able to fulfil the design requirements selected at the end of the DEMO pre-conceptual design phase. In this work, the thermo-mechanical analysis and the design update of the top cap (TC) region of the DEMO WCLL Central Out-board Blanket (COB) segment is presented. The scope of the work is to find a design solution of the WCLL COB TC region abl…
On the influence of the supporting frame on the nuclear response of the Helium-Cooled Lithium Lead Test Blanket Module for ITER
2006
Abstract Within the European Fusion Technology Programme, very intense research activities have been promoted on the Helium-Cooled Lithium Lead (HCLL) breeding blanket concept with the specific aim of manufacturing a Test Blanket Module (TBM) to be irradiated in ITER. HCLL-TBM is foreseen to be located in an ITER equatorial port, being housed inside a proper steel-supporting frame. In particular, since that frame has been designed to provide two cavities separated by a dividing plate and HCLL-TBM is foreseen to fill just one of them, its nuclear response could vary accordingly to the filling status of the other one, unless the dividing plate is thick enough to isolate the components housed …
SiC-based sandwich material for Flow Channel Inserts in DCLL blankets: Manufacturing, characterization, corrosion tests
2017
This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under grant agreement No 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission.
Optimization of the breeder zone cooling tubes of the DEMO Water-Cooled Lithium Lead breeding blanket
2016
Abstract The determination of an optimal configuration for the breeder zone (BZ) cooling tubes is one of the most important issues in the DEMO Water-Cooled Lithium Lead (WCLL) breeding blanket R&D activities, since BZ cooling tubes spatial distribution should ensure an efficient heat power removal from the breeder, avoiding hotspots occurrence in the thermal field. Within the framework of R&D activities supported by the HORIZON 2020 EUROfusion Consortium action on the DEMO WCLL breeding blanket design, a campaign of parametric analyses has been launched at the Department of Energy, Information Engineering and Mathematical Models of the University of Palermo (DEIM), in close cooperation with…
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.
2019
Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…