Search results for "CLO"
showing 10 items of 9986 documents
Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period
2023
Background Measures of biological aging range from DNA methylation (DNAm)-based estimates to measures of physical abilities. The purpose of this study was to compare DNAm- and physical functioning-based measures of biological aging in predicting mortality. Methods We studied 63- to 76-year-old women (N = 395) from the Finnish Twin Study on Aging (FITSA). Participants’ biological age (epigenetic clocks DNAm GrimAge and DunedinPACE) was estimated using blood DNAm data. Tests of physical functioning conducted under standardized laboratory conditions included the Timed Up and Go (TUG) test and 10-m walk test. Mortality hazard ratios (HRs) were calculated per every one standard deviation (SD) in…
Does the epigenetic clock GrimAge predict mortality independent of genetic influences : an 18 year follow-up study in older female twin pairs
2021
Background: Epigenetic clocks are based on DNA methylation (DNAm). It has been suggested that these clocks are useable markers of biological aging and premature mortality. Because genetic factors explain variations in both epigenetic aging and mortality, this association could also be explained by shared genetic factors. We investigated the infuence of genetic and lifestyle factors (smoking, alcohol consumption, physical activity, chronic diseases, body mass index) and education on the association of accelerated epigenetic aging with mortality using a longitudinal twin design. Utilizing a publicly available online tool, we calculated the epigenetic age using two epigenetic clocks, Horvath D…
Parametrizētu algoritmu paātrinājumi kvantu datoram
2021
Darbā tiek aplūkots, kā uz kvantu datora iespējams paātrināt zināmus parametrizētus algoritmus problēmām “Closest string”, “Cluster vertex deletion”, “Cluster editing”, “Vertex cover” un “Longest path” problēmu risinājumiem, ka arī to uzlabošana kvantu datoram, izmantojot kvantu algoritmus meklēšanas koka apstaigāšanai un dinamiskai programmēšanai. Ir parādīts, kā izveidot kvantu algoritmus “Cluster vertex deletion” problēmas risinājumam ar laika sarežģītību 𝑂(1.7321^𝑘 * √𝑘 * 𝑛^3) un “Vertex cover” problēmai ar laiku 𝑂(1.175^𝑘 * 𝑘^𝑂(1) + 𝑛√𝑚), kas ir labāk, nekā labākajiem zināmajiem algoritmiem ar laiku 𝑂(1.9102^𝑘 * (𝑛 + 𝑚)) un 𝑂(1.2738^𝑘 + 𝑘𝑛), attiecīgi. Ka arī ir parād…
Flow-bed interactions analysis and application of automatic close range digital photogrammetric survey in a laboratory flume
2014
This paper reports on a laboratory study in which the automatic digital photogrammetric survey was applied to derive the high-resolution Digital Surface Model (DSM) of the bed topography, used for the flow-bed interactions analysis, in a large amplitude meandering laboratory flume. The analysis has been conducted with the aid of detailed data of three-dimensional flow field previously collected using the acoustic Doppler velocity profiler DOP2000. The applied surveying procedure has allowed the evaluation of the DSM with a resolution of ±0.5 mm. The detailed DSM has been compared with peculiar maps describing the flow velocity pattern (downstream and the crossstream flows) and the shear vel…
Laiksakritības vadības modeļi JVM platformas programmēšanas valodās
2015
Programmētājam izstrādājot lietotnes dažkārt nākas tajās realizēt skaitļošanas procesus, kuri notiek vienlaicīgi, t.i., laiksakritīgi. Šāda nepieciešamība kļuvusi vēl aktuālāka līdz ar daudzkodolu centrālo procesoru izplatību. Lai varētu pilnā apjomā izmantot daudzos kodolus uz tiem vienlaicīgi jādarbina kādas lietotnes daļas. Lai to sasniegtu jāizmanto tāda vai citāda veida laiksakritīgas programmēšanas veids, jo programmējot standarta paņēmieniem sasniedzama tikai laiksecīga programmas izpilde. Rodas jautājums par tāda vai citāda veida laiksakritības vadības modeļa izmantošanu, kas ļauj kontrolēt, kādā veidā laiksakritīgas lietotnes daļas izmanto datora resursus un mijiedarbojas savā star…
A Scan-to-BIM Approach for the Management of Two Arab-Norman Churches in Palermo (Italy)
2023
The paper shows the results of the research activities carried out by the Department of Engineering at the University of Palermo (Italy), which assessed the application of the Heritage Building Information Modelling (HBIM) methodology through a Scan-to-BIM approach to two local churches belonging to the medieval period. This project was motivated by a renewed interest from the city administrators towards the conservation of cultural heritage dating back to the Arab-Norman domination in Sicily since one of the two buildings was included in the UNESCO World Heritage Sites list in 2015. The morpho-typological style of the churches has been acquired by high-detailed 3D surveys, which provided t…
Mass Spectroscopy in Penning Trap
2009
While mass spectrometry in Paul traps serves well mainly for molecular analysis in chemistry, Penning traps provide high accuracy and precision. The technique is based on the fact that the ratio of cyclotron frequencies ω c = (Q/M)B of two ions in the same magnetic field B gives directly the ratio of their masses ω c(1)/ω c(2) = M(2)/M(1). If carbon-12 as the standard of the atomic mass scale is used as reference, the mass of the ion of interest is obtained directly in atomic units. Although the cyclotron frequency is not an eigenfrequency of the Penning trap, it can be obtained from combinations of ω+, ω, and ω z as evident from the set of equations (1.31)-(1.33). In the ideal case of a pe…
Immunoaffinity purification and characterization of mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis.
2008
Abstract Background The interconversion of two important energy metabolites, 3-hydroxybutyrate and acetoacetate (the major ketone bodies), is catalyzed by D-3-hydroxybutyrate dehydrogenase (BDH1: EC 1.1.1.30), a NAD+-dependent enzyme. The eukaryotic enzyme is bound to the mitochondrial inner membrane and harbors a unique lecithin-dependent activity. Here, we report an advanced purification method of the mammalian BDH applied to the liver enzyme from jerboa (Jaculus orientalis), a hibernating rodent adapted to extreme diet and environmental conditions. Results Purifying BDH from jerboa liver overcomes its low specific activity in mitochondria for further biochemical characterization of the e…
BIFOCAL PAIRS OF IMAGES FOR LOW-COST SURVEY IN CLOSE RANGE PHOTOGRAMMETRY
2019
Abstract. This paper present a method for close range photogrammetry based on an camera positioning scheme in which two cameras capture an equal portion of an object at the same scale, but have different focal lengths and camera-to-object distances. This scheme is alternative to the stereoscopic scheme and is associated with a system of equations which permits one to calculate first the relief displacement of points on a photograph and then their relief relative to a reference plane. The obtained relief and relief displacement values can be used to produce low-cost orthophotographs by using software for image processing, which doesn’t need to be dedicated, but has to provide measurement and…
HYPERSPECTRAL REFLECTANCE SIGNATURES AND POINT CLOUDS FOR PRECISION AGRICULTURE BY LIGHT WEIGHT UAV IMAGING SYSTEM
2018
Abstract. The objective of this investigation was to study the use of a new type of a low-weight unmanned aerial vehicle (UAV) imaging system in the precision agriculture. The system consists of a novel Fabry-Perot interferometer based hyperspectral camera and a high-resolution small-format consumer camera. The sensors provide stereoscopic imagery in a 2D frame-format and they both weigh less than 500 g. A processing chain was developed for the production of high density point clouds and hyperspectral reflectance image mosaics (reflectance signatures), which are used as inputs in the agricultural application. We demonstrate the use of this new technology in the biomass estimation process, w…