Search results for "CLR"
showing 7 items of 7 documents
Genome-wide association study reveals the locus responsible for microtia in Valle del Belice sheep breed.
2018
Microtia is a congenital deformity of the outer ear with phenotypes varying from a small auricle to total absence (anotia). The genetic basis is still poorly understood, and very few studies have been performed in sheep. Valle del Belice sheep is a breed showing microtia. The aim of this study was to identify the potential genomic regions involved in microtia in sheep. A total of 40 individuals, 20 with microtia and 20 normal, were genotyped with the Illumina OvineSNP50 BeadChip. The comparison among the results from a genome-wide association study, Fisher's exact test and FST analysis revealed a single strong association signal: rs419889303 on chromosome 1, located within intron 3 of the C…
Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils
2021
Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T cells, but was independent of IFN-γ and other classical antibacterial effector mechanisms. Further, mice deficient for immune recognition and signaling via Toll-like receptor (TLR) 2, TLR4 or MyD88 were unimpaired in pathogen control. In contrast, animals lacking adaptor molecules of Nod-like receptors (NLR) such as RIP2 or ASC showed delayed clearance of A. phagocytophilum. In the present study, we investigated the contribution of further pattern…
Fixed points of weakly compatible mappings satisfying generalized $\varphi$-weak contractions
2014
In this paper, utilizing the notion of the common limit range property, we prove some new integral type common fixed point theorems for weakly compatible mappings satisfying a \(\varphi \)-weak contractive condition in metric spaces. Moreover, we extend our results to four finite families of self mappings, and furnish an illustrative example and an application to support our main theorem. Our results improve, extend, and generalize well-known results on the topic in the literature.
Equivalences between refractive index and equilibrium water content of conventional and silicone hydrogel soft contact lenses from automated and manu…
2007
PURPOSE: The purpose of the present study was to develop mathematical relationships that allow obtaining equilibrium water content and refractive index of conventional and silicone hydrogel soft contact lenses from refractive index measures obtained with automated refractometry or equilibrium water content measures derived from manual refractometry, respectively. METHODS: Twelve HEMA-based hydrogels of different hydration and four siloxane-based polymers were assayed. A manual refractometer and a digital refractometer were used. Polynomial models obtained from the sucrose curves of equilibrium water content against refractive index and vice-versa were used either considering the whole range…
On coincidence and common fixed point theorems of eight self-maps satisfying an FM-contraction condition
2019
In this paper, a new type of contraction for several self-mappings of a metric space, called FM-contraction, is introduced. This extends the one presented for a single map by Wardowski [Fixed points of a new type of contractive mappings in complete metric spaces, Fixed Point Theory Appl., 2012:94, 2012]. Coincidence and common fixed point of eight self mappings satisfying FM-contraction conditions are established via common limit range property without exploiting the completeness of the space or the continuity of the involved maps. Coincidence and common fixed point of eight self-maps satisfying FM-contraction conditions via the common property (E.A.) are also studied. Our results generaliz…
Refractive index and equilibrium water content of conventional and silicone hydrogel contact lenses
2006
Prova tipográfica (In Press)
Regulation of physiological differentiation in Nonomuraea sp. ATCC 39727
2014
The Actinomycete Nonomuraea produces the glycopeptide A40926, precursor of dalbavancin, a novel lipoglycopeptide homologous to vancomycin that could be used against emerging resistant Gram-positive bacteria. The A40926 biosynthetic gene cluster (dbv), which consists of 37 genes, encodes two regulators, Dbv3 (LuxR-like) and Dbv4 (StrR-like), as well as the response regulator (Dbv6) and the sensor-kinase (Dbv22) of a putative two-component system. Previous work demonstrated a positive role of Dbv4 in antibiotic production by activating the transcription of 13 dbv genes; up to now no role was assigned to Dbv3, Dbv6 and Dbv22. In addition, an IclR-like protein is thought to be involved in dbv4 …