Search results for "CMA"

showing 8 items of 188 documents

Genotype-driven pharmacokinetic simulations of warfarin levels in Puerto Ricans.

2020

Abstract Objectives The inter-individual variability of warfarin dosing has been linked to genetic polymorphisms. This study was aimed at performing genotype-driven pharmacokinetic (PK) simulations to predict warfarin levels in Puerto Ricans. Methods Analysis of each individual dataset was performed by one-compartmental modeling using WinNonlin®v6.4. The k e of warfarin given a cytochrome P450 2C9 (CYP2C9) genotype ranged from 0.0189 to 0.0075 h−1. K a and V d parameters were taken from literature. Data from 128 subjects were divided into two groups (i.e., wild-types and carriers) and statistical analyses of PK parameters were performed by unpaired t-tests. Results In the carrier group (n=6…

medicine.medical_specialtyGenotypeCmax030204 cardiovascular system & hematology030226 pharmacology & pharmacyGastroenterologyArticle03 medical and health sciences0302 clinical medicinePharmacokineticsVitamin K Epoxide ReductasesInternal medicineGenotypemedicineHumansPharmacology (medical)DosingGeneral Pharmacology Toxicology and PharmaceuticsCYP2C9GenotypingCytochrome P-450 CYP2C9business.industryWarfarinArea under the curveFarmàcia InvestigacióAnticoagulantsHispanic or LatinoAryl Hydrocarbon HydroxylasesWarfarinbusinessmedicine.drugDrug metabolism and personalized therapy
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Hypovitaminosis D and orthostatic hypotension: A systematic review and meta-analysis

2016

Objectives: Orthostatic hypotension is a common condition among older adults and is associated with a range of deleterious outcomes. Recently, interest has developed in hypovitaminosis D (defined as low 25 hydroxiyVitamin D levels) as a potential risk factor for orthostatic hypotension. We conducted a systematic review and meta-analysis examining the association of orthostatic hypotension between study participants with and without hypovitaminosis D, including the adjustment of potential confounders (age, sex, BMI, renal function, comorbidities, seasonality, use of antihypertensive medications, and supplementation with cholecalciferol). Methods: A systematic literature search of major elect…

medicine.medical_specialtyOdds ratiosCross-sectional studyPhysiologyCMA030204 cardiovascular system & hematologyvitamin D deficiencyserum 25 hydroxyVitamin Dorthostatic hypotension03 medical and health sciencesOrthostatic vital signsHypotension Orthostatic0302 clinical medicineRisk FactorsInternal medicinemeta-analysis orthostatic hypotension serum 25 hydroxyvitamin D vitamin DOrthostatic hypotension; vitamin DmedicineVitamin D and neurologyPrevalenceInternal MedicineHumans030212 general & internal medicineVitamin DORsbusiness.industryConfoundingConfidence intervalCase-control studyOdds ratioParathyroidhormoneComprehensive meta-analysisCImedicine.diseaseVitamin D Deficiency3. Good healthmeta-analysis25 hydroxyvitamin DCross-Sectional StudiesMeta-analysisCase-Control StudiesPhysical therapy25OHDmeta-analysis; orthostatic hypotension; serum 25 hydroxyVitamin D; Vitamin D; Internal Medicine; Physiology; Cardiology and Cardiovascular MedicinebusinessCardiology and Cardiovascular Medicine[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyPTH
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Skārienjūtīgu augstas izšķirtspējas monitoru sienas izstrāde

2017

Daudz-monitoru sienas risinājumi tiek bieži izmantoti, lai attēlotu liela apjoma informāciju, kura nav manuāli jāšķirsta. Siena uzreiz parāda vajadzīgo informāciju, ko nevar parādīt uz viena monitora bez pāršķirstīšanas, kas uzlabo ātrdarbību datu piekļūšanai no cilvēka puses. Diemžēl, bezgalīgi palielinot monitoru skaitu sienā, rodas produktivitātes problēmas no citiem aspektiem, kā fiziskā navigācija un fokusa zaudēšana. Skārienjūtīgo monitoru sienas atļautu izmantot citu pieeju fiziskajai navigācijai vai satura manipulācijai, kur lietotājs var ietekmēt monitoru saturu ar skāriena ievadu konkrētam monitoram monitora sienā. Klasisko monitoru gadījumā, lietotājam vajadzētu iet pie servera, …

monitoru sienaDatorzinātneBoost bibliotēkaRaspberry PiCMakeC++
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Režģa Bolcmaņa metodes lietojums konvekcijas-difūzijas-reakcijas problēmām

2022

Darbs ir veltīts režģa Bolcmaņa metodes pielietojumiem Navjē-Stoksa vienādojuma, konvekcijas-difūzijas-reakcijas vienādojuma un to sistēmu risināšanā. Šādas sistēmas parādās, modelējot enerģijas un masas pārneses uzdevumus, tostarp tādus, kas iekļauj ķīmiskās reakcijas. Darba ietvaros ir apskatīta metodes implementācija ar dažāda veida robežnosacījumiem, un izstrādāti MATLAB risinājumi divās telpas dimensijās plūsmai Teslas ventilī, degšanas procesam porainā vidē, siltumvadīšanas vienādojumam un cilindra aptecēšanai. Ir piedāvāti ieteikumi optimālai metodes implementācijai.

režģa Bolcmaņa metodedabiskā konvekcijaNavjē-Stoksa vienādojumsMatemātikadegšanakonvekcijas-difūzijas-reakcijas vienādojums
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The Role of Corporate Social Responsibility and Its Influences on Vietnamese Small and Medium-sized Enterprises (SMEs) in Ho Chi Minh City

2020

In the new era, the importance of Corporate Social Responsibility (CSR) for business organizations is a matter of primary concern and has been researched by scholars around the world. Interest in CSR in business enterprises is often neglected due to its high-cost factor and the enterprises only focused on its operations and profitability for the existence of a business. If the enterprises have a good CSR policy within their development strategy, they will attain greater success. It was deemed that the empirical study adopted a descriptive survey method, 103 data samples were selected from the SMEs for analysis. The results indicated that SME management who adopted and implemented CSR polici…

sustainable developmentVietnamkestävä kehitysyritysvastuuComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONtyöntekijätbrändäysbrandingcorporate responsibilityBranding developmentCSRCommunity DevelopmentEmployee engagement
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Regularity for nonlinear stochastic games

2015

We establish regularity for functions satisfying a dynamic programming equation, which may arise for example from stochastic games or discretization schemes. Our results can also be utilized in obtaining regularity and existence results for the corresponding partial differential equations. peerReviewed

viscosity solutionsDiscretization01 natural sciencesMathematics - Analysis of PDEsBellman equationComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATIONFOS: MathematicsApplied mathematicstug-of-war0101 mathematicsMathematics - Optimization and ControlMathematical PhysicsMathematicsstokastiset prosessitPartial differential equationApplied Mathematics91A15 35J92 35B65 35J60 49N60010102 general mathematicsta111dynamic programming principletug-of-war with noise with space dependent probabilities010101 applied mathematicsNonlinear systemOptimization and Control (math.OC)p-LaplaceAnalysisAnalysis of PDEs (math.AP)
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Zinātnieks dzimtenē : (Atmiņas par profesoru Pēteri Šmitu)

1929

Atmiņās J. Lapiņš ieskicē gan savu, gan citu raunēniešu viedokļus par prof. P. Šmitu, piemin citus ievērojamus darbiniekus no Raunas novada, apkārtējo un profesora viedokli par 1905. gada revolūciju Latvijā, Latvijas karoga krāsu, kā arī P. Šmita kundzes publicētajām Ķīnas ceļojuma piezīmēm "Mājas Viesa Mēnešrakstā".

vēsture:HUMANITIES and RELIGION [Research Subject Categories]Krēsliņš Kārlis (1860–1929)Ducmanis Kārlis (1881-1943)valodniecībaDermanis Vilis (1875-1938)Kalniņš Alfrēds (1879-1951)Šmits PēterisLapiņš Jānis Eduards (1885-1941)Cimze Jānis (1814-1881)mitoloģijaAuškāps Jūlijs (1884–1942)Zālīte Pēteris (1864-1939)Švābe Arveds
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Évaluation ergonomique du serveur intranet Bull

1997

Rapport de contrat Bull INRIA; Évaluation par inspection du serveur intranet Bull

évaluation par inspection[SHS.INFO]Humanities and Social Sciences/Library and information sciences[SCCO.COMP]Cognitive science/Computer scienceSoftware_PROGRAMMINGTECHNIQUES[SHS.INFO] Humanities and Social Sciences/Library and information sciencesdocument électroniqueComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMSInformationSystems_MODELSANDPRINCIPLES[SCCO.COMP] Cognitive science/Computer science[ SCCO.COMP ] Cognitive science/Computer scienceComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION[ SHS.INFO ] Humanities and Social Sciences/Library and information sciencesergonomie informatiquedocument numériqueHardware_CONTROLSTRUCTURESANDMICROPROGRAMMINGévaluation d'un intranet
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