Search results for "CML"
showing 10 items of 91 documents
Role of CML exosomes in the crosstalk between chronic myelogenous leukemia and bone-marrow derived exosomes
2012
Crosstalk between chronic myelogenous leukemia (CML) and bone marrow stromal cells: role of interleukin 8 and CML derived- exosomes
2013
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized by the t(9:22) (q34:q11) reciprocal translocation, resulting in the expression of the chimeric Bcr–Abl oncoprotein with constitutive tyrosine kinase activity. Exosomes (Exo) are small vesicles of endosomal origin and of 40-100 nm diameter released by many cell types including cancer cells. Several data indicate that Exo play an important role in cell-to-cell communication and tumor-stroma interaction, thus potentially affecting cancer progression. It is well known that stromal microenvironment contributes to disease progression through the establishment of a bi-directional crosstalk with cancer cells. In the b…
Molecular profiling of imatinib resistant chronic myelogenous leukemia cells
2010
Crosstalk between chronic myelogenous leukemia (CML)and bone marrow stromal cells: role of exosomes in the IL8- dependent signalling mediated by EGFR…
2014
Introduction: CML is a myeloproliferative disorder characterized by Bcr-Abl oncoprotein with a constitutive tyr-kinase activity. Exosomes (exo) shed by cancer cells potentially affect tumor-stroma interaction through the establishment of a bi-directional crosstalk. Interleukin-8 (IL8) is a proinflammatory chemokine that regulate proliferation and survival of cancer cells. We previously demonstrated that CML-derived exo modulate bone marrow microenvironment through the IL8 secretion from stromal cells. EGFR, as well as IL8, regulate cell proliferation and survival; it has been recently demonstrated that EGFR ligands can signal via exosomes shed by cancer cells. We hypothesized that the effec…
Exosomes mediate a paracrine interplay between Chronic Myelogenous Leukemia and stromal cells: a role for interleukin 8
2013
Mobile Security with Location-Aware Role-Based Access Control
2012
Published version of an article from the book: Security and privacy in mobile information and communication systems. Also available on SpringerLink: http://dx.doi.org/10.1007/978-3-642-30244-2_15 This paper describes how location-aware Role-Based Access Control (RBAC) can be implemented on top of the Geographically eXtensible Access Control Markup Language (GeoXACML). It furthermore sketches how spatial separation of duty constraints (both static and dynamic) can be implemented using GeoXACML on top of the XACML RBAC profile. The solution uses physical addressing of geographical locations which facilitates easy deployment of authorisation profiles to the mobile device. Location-aware RBAC c…
ViSPE: A Graphical Policy Editor for XACML
2015
In this paper we present the Visual Security Policy Editor (ViSPE), a policy-maker-friendly graphical editor for the eXtensible Access Control Markup Language (XACML). The editor is based on the programming language Scratch and implemented in Smalltalk. It uses a graphical block-based syntax for declaring access control polices that simplifies many of the cumbersome and verbose parts of XACML. Using a graphical language allows the editor to aid the policy-maker in building polices by providing visual feedback and by grouping blocks and operators that fit together and also indicating which blocks that stick together. It simplifies building policies while still maintaining the basic structure…
Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism.
2014
Background Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL oncoprotein, with a constitutive tyrosine kinase activity. Consequently, BCR-ABL causes increased proliferation, inhibition of apoptosis, and altered adhesion of leukemic blasts to the bone marrow (BM) microenvironment. It has been well documented that cancer cells can generate their own signals in order to sustain their growth and survival, and recent studies have revealed the role of cancer-derived exosomes in activating signal transduction pathways involved in cancer cell…
Mikroservisa autorizēšanās sistēma balstīta uz XACML standartu
2017
Bakalaura darbā ir izpētīts XACML standarts, kas ir vecākais un populārākais no diviem atribūtu bāzētās piekļuves kontroles standartiem. Galvenais mērķis bakalaura darba izstrādē bija izstrādāt uz XACML standarta balstītu, bet ne obligāti tā implementējošu autorizēšanās sistēmu, kas ir veidota Node.js vidē TypeScript programmēšanas valodā un ir vieglāk izmantojama par esošajiem risinājumiem. Viens no veidiem, kā padarīt implementēto sistēmu vieglāk izmantojumu, bija izstrādāt jaunu, uz XML nebalstītu politiku valodu un tās apstrādes modeli. Teorētiskajā daļā ir aprakstīts XACML standarts - tā politiku valoda, darbības mehānismi un arhitektūra -, sniegts pārskats par esošajām atvērtā pirmkod…
A novel policy-driven reversible anonymisation scheme for XML-based services
2015
Author's version of an article in the journal: Information Systems. Also available from the publisher at: http://dx.doi.org/10.1016/j.is.2014.05.007 This paper proposes a reversible anonymisation scheme for XML messages that supports fine-grained enforcement of XACML-based privacy policies. Reversible anonymisation means that information in XML messages is anonymised, however the information required to reverse the anonymisation is cryptographically protected in the messages. The policy can control access down to octet ranges of individual elements or attributes in XML messages. The reversible anonymisation protocol effectively implements a multi-level privacy and security based approach, s…