Search results for "CNS"

Besteht eine Beeinträchtigung der ZNS-Aktivität durch gepulste elektromagnetische Felder? - Do Pulsed Electromagnetic Fields Impair CNS Activity?

2001

In the present pilot study we examined the effects of electromagnetic fields on the biological organism. The study was prompted by discussions on the possible effects on the nervous system and cognitive processes of fields produced by mobile phones. The experiments were performed in an electrophysiological laboratory. Eleven volunteers were exposed to pulsed electromagnetic fields (GSM standard). The psychophysiological method of assessing the order threshold (Ordnungsschwelle = OS) was used to examine cognitive performance. Under the test conditions, nine of the subjects showed a loss of mental regeneration, as reflected by an increase in the OS, in comparison with the field-free situation…

Poliprenolu iedarbība un to ietekme uz atorvastatīna efektiem WISTAR līnijas žurkām uzvedības, atmiņas un analgēzijas testos

2015

Poliprenoli (PP) ir izdalīti no augiem, tai skaitā, no skujkokiem. To ietekme uz centrālās nervu sistēmas (CNS) procesiem ir ļoti maz pētīta. Ir zināms, ka gan PP, gan holesterols un doliholi veidojas caur mevalonskābes atkarīgiem ceļiem (MVA) ar 3-hidroksi-3-metilglutaril-koenzīma A reduktāzes palīdzību. Šo enzīmu inhibē holesterola biosintēzes inhibītori statīni, kuru ilgstoša lietošana slimniekiem nelabvēlīgi ietekmē kognitīvās funkcijas (Schilling et al., 2014). Darba mērķis bija noteikt PP, atorvastatīna (AT), kā arī to kombinācijas ietekmi uz izmēģinājuma dzīvnieku (žurku) vispārējo aktivitāti, atmiņas procesiem un sāpju slieksni. Iegūtie dati liecina, ka AT piemīt pretsāpju iedarbība…

Are functional gi disorders gastroenterological or neurological diseases?

2009

Gers ķirurģiskas ārstēšanas rezultātu analīze pacientiem ar organisku CNS bojājumu

2018

Bērni ar organiskiem CNS bojājumiem bieži cieš no GERS. ( Seung Kim et al.,2017) Savukārt viena no GERS ārstēšanas metodēm ir fundoplikācija, bet vēljoprojām operācijas ietekme uz dzīves kvalitāti ir neskaidra. Pētījuma mērķis ir noteikt vai ir dzīves kvalitātes uzlabošanās pacientiem ar organiskiem CNS bojājumiem pēc gastroezofageālās refluksa slimības ķirurģiskas ārstēšanas. Pētījums ir retrospektīvs, dati tika ievākti gan no slimnīcas arhīva datorprogrammas, gan arī arhīvā tika apskatītas interesējošas pacietnu vēsturītes, par pacientiem, kuriem gastroezofageālā refluksa slimība tika ārstēta ķirurģiski laika posmā no 2008. gada 1 janvāra līdz 2017. gad 30 decembrim, ir organiski CNS bojā…

Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages

2019

Abstract Tumor-derived primary cells are essential for in vitro and in vivo studies of tumor biology. The scarcity of this cellular material limits the feasibility of experiments or analyses and hence hinders basic and clinical research progress. We set out to determine the minimum number of cells that can be analyzed with standard laboratory equipment and that leads to reliable results, unbiased by cell number. A proof-of-principle study was conducted with primary human monocyte-derived macrophages, seeded in decreasing number and constant cell density. Gene expression of cells stimulated to acquire opposite inflammatory states was analyzed by quantitative PCR. Statistical analysis indicat…

Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome – Report from the German LGG Studies

2021

Successive multicenter studies for pediatric low-grade glioma (LGG) in Germany were accompanied by a doubling of annual recruitment over 2 decades. We investigated whether this increase conveyed a change of epidemiologic characteristics or survival.Participating centers reported 4634 patients with the radiologic/histologic diagnosis of LGG (1996-2018), rising from 109 to 278/year. Relating these numbers to all pediatric CNS tumors registered at the German Childhood Cancer Registry, the LGG fraction and annual crude incidence rates increased (32% to 51%; 0.94 to 2.12/100,000 children/adolescents15 years). The consecutive LGG studies recruited 899 (HIT-LGG 1996), 1592 (SIOP-LGG 2004), and 183…

Neuroplasticity and environment: A pharmacotherapeutic approach toward preclinical and clinical understanding

2021

International audience; Emerging research in the field of behavioral neuroscience has demonstrated the fundamental role of the cerebral organization. For brain development, various important functions are required for instance synaptic plasticity and neurogenesis. This property is described in terms of neuroplasticity. Neuroplasticity denotes the extraordinary ability of the brain for the recognition of its structure and function after an experience with some external stimuli and involves in the various behavioral processes of the brain such as cognitive functions. It has multiple factors that can range from gene alteration to environmental factors. Environmental factors exert both negative…

UVB light attenuates the systemic immune response in CNS autoimmunity

2014

Brain protein expression changes in WAG/Rij rats, a genetic rat model of absence epilepsy after peripheral lipopolysaccharide treatment

2013

Peripheral injection of bacterial lipopolysaccharide (LPS) facilitates 8–10 Hz spike-wave discharges (SWD) characterizing absence epilepsy in WAG/Rij rats. It is unknown however, whether peripherally administered LPS is able to alter the generator areas of epileptic activity at the molecular level. We injected 1 mg/kg dose of LPS intraperitoneally into WAG/Rij rats, recorded the body temperature and EEG, and examined the protein expression changes of the proteome 12 h after injection in the fronto-parietal cortex and thalamus. We used fluorescent two-dimensional differential gel electrophoresis to investigate the expression profile. We found 16 differentially expressed proteins in the front…

Effects of DA-Phen, a dopamine-aminoacidic conjugate, on alcohol intake and forced abstinence

2016

The mesolimbic dopamine (DA) system plays a key role in drug reinforcement and is involved in the development of alcohol addiction. Manipulation of the DAergic system represents a promising strategy to control drug-seeking behavior. Previous studies on 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DA-Phen) showed in vivo effects as a DA-ergic modulator. This study was aimed at investigate DA-Phen effects on operant behavior for alcohol seeking behavior, during reinstatement following subsequent periods of alcohol deprivation. For this purpose, male Wistar rats were tested in an operant paradigm of self-administration; behavioral reactivity and anxiety like-behavior durin…