Search results for "COD"
showing 10 items of 2985 documents
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of th…
2022
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10 % of the mutations affecting the CFTR gene are "stop" mutations, which generate a Premature Termination Codon (PTC), thus resulting in the synthesis of a truncated CFTR protein. A way to bypass PTC relies on ribosome readthrough, that is the capacity of the ribosome to skip a PTC, thus generating a full-length protein. “TRIDs” are molecules exerting ribosome readthrough and for some of them the mechanism of action is still under debate. By in silico analysis as well as in vitro studies, we investigate a possible mechanism of action (MOA) by whic…
Movement and Emotional Facial Expressions during the Adult Attachment Interview: Interaction Effects of Attachment and Anxiety Disorder
2019
<b><i>Introduction:</i></b> Adult attachment is commonly associated with emotion regulation. Less is known about the nonverbal embodiment of adult attachment. <b><i>Objective:</i></b> We hypothesized that dismissing attachment is related to less movement and fewer facial expressions of emotions, whereas preoccupied attachment is associated with more negative emotional facial expressions. Moreover, the interaction of attachment and the presence of an anxiety disorder (AD) was explored. <b><i>Methods:</i></b> The sample included 95 individuals, 21 with AD without comorbidity, 21 with AD and comorbid major depression (AD-C…
Gene symbol: f9.
2007
A generalized method for the design of ergodic sum-of-cisoids simulators for multiple uncorrelated rayleigh fading channels
2010
In this paper, we present a new method for the design of ergodic sum-of-sinusoids (SOS) simulation models for multiple uncorrelated Rayleigh fading channels. The method, which is intended for a special class of SOS models, known as sum-of-cisoids (SOC) models, can be used to generate an arbitrary number of uncorrelated Rayleigh fading waveforms with specified Doppler power spectral characteristics. This is in contrast to the SOS simulators currently available in the open literature that have been designed under the isotropic scattering assumption, which are limited to the simulation of uncorrelated channels characterized by Clarke's U-shaped Doppler power spectral density (DPSD). The excell…
Le Famiglie e le Disabilità
2019
Il vertice di osservazione dal quale descriveremo gli elementi dei paragrafi a seguire che, a nostro parere, fondano e sostanziano la psicodinamica delle disabilità, è il vertice psicoanalitico. Secondo l’orientamento psicoanalitico, il sintomo è fondamentale, non perché vada subito silenziato tentando così di eliminare la sofferenza che ne deriva, ma perché come un reperto archeologico, ne va ricercato pazientemente il senso, riconnettendo legami perduti all’interno della vita del soggetto, allargando lo spazio di pensiero, per incrementare la padronanza della vita psichica e il piacere relativo al funzionamento della mente. Il sintomo – di per sé fisso, denso, immutabile, ignorante - va i…
Personalización del tratamiento antineoplásico con capecitabina en pacientes con carcinoma colorrectal
2019
Objetivo: desarrollar y validar un modelo farmacocinético – farmacodinámico (PKPD) poblacional de capecitabina que proporcione información útil en la personalización del tratamiento en pacientes con carcinoma colorrectal. Métodos: estudio prospectivo observacional post-autorización desarrollado en el Hospital Universitario Doctor Peset de Valencia entre febrero de 2015 y agosto 2016 en pacientes con carcinoma colorrectal. Las determinaciones de las concentraciones plasmáticas de CAP y sus metabolitos (5-DFUR y 5-FU) se realizaron a partir de muestras de sangre obtenidas 1h, 2h y 3h post-administración. Los recuentos absolutos de neutrófilos (RAN) se realizaron entre los días 15-24 post…
Farmacología clínica aplicada a la enfermería (2009/2010)
2009
El objetivo fundamental de la farmacología es el conocimiento de los fármacos, de sus interacciones con sistemas biológicos, de su utilidad en el tratamiento, prevención y diagnóstico de enfermedades y de las reacciones adversas a que pueden dar lugar.
desat1 and the Evolution of Pheromonal Communication in Drosophila
2009
1749-6632 (Electronic) 0077-8923; The evolution of communication is a fundamental biological problem. The genetic control of the signal and its reception must be tightly coadapted, especially in interindividual sexual communication. However, there is very little experimental evidence for tight genetic linkage connecting the emission of a signal and its reception. In Drosophila melanogaster, desat1 is the first known gene that simultaneously affects the emission and the perception of sex pheromones. Our experiments show that both aspects of pheromonal communication (the emission and the perception of sex pheromones) depend on distinct genetic control and may result from tissue-specific expre…
desat1: A Swiss army knife for pheromonal communication and reproduction?
2012
International audience; The desat1 gene possesses an extraordinary-maybe unique-feature in the control of sensory communication systems: it codes for the two principal and complementary aspects-the emission and the reception-of Drosophila sex pheromones. These two complex aspects depend on separate genetic control indicating that desat1 pleiotropically acts on pheromonal communication. This gene also control other characters either related to reproduction and to osmoregulation. Such a functional pleiotropy may be related to the molecular structure of desat1 gene which combines a highly conserved coding region with fast evolving regulatory regions: It produces at least five transcripts all g…
Pharmacotherapy for Breakthrough Cancer Pain
2012
Breakthrough pain (BTP) is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. The principal pharmacological treatment of BTP is represented by the administration of opioids as needed. Oral opioids have traditionally been the only available drugs for BTP. However, the onset and duration of action of oral opioids such as morphine or oxycodone may not be suitable for treating many episodes of BTP that are of short onset and duration. Transmucosal administration of lipophilic substances has gained a growing popularity in recent years due to the …