Search results for "COD"
showing 10 items of 2985 documents
Pharmacodynamic Monitoring of the Efficacy of a Targeted Therapy with Midostaurin By Plasma Inhibitor Activity (PIA) Analysis in FLT3 -ITD Positive A…
2015
Abstract Background: Activating mutations in receptor tyrosine kinases like FLT3 (FLT3mut) lead to an aberrant signal transduction thereby causing an increased proliferation of hematopoietic cells. Internal tandem duplications (FLT3-ITD) or mutations in the tyrosine kinase domain (FLT3-TKD) occur in about 25% of younger adult patients (pts) with acute myeloid leukemia (AML), with FLT3 -ITD being associated with an unfavourable outcome. FLT3mut present an excellent target for small molecule tyrosine kinase inhibitors (TKI). The multi-targeted kinase inhibitor midostaurin (PKC412) is currently under investigation as a FLT3-inhibitor in combination with intensive chemotherapy. Monitoring of th…
Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity
2019
Background: In patients with NAFLD liver biopsy is the gold standard to detect NASH and stage liver fibrosis. We aimed to identify differentially expressed mRNAs and non-coding RNAs in serum samples of biopsy-diagnosed mild and severe NAFLD patients with respect to controls and to each other. Methods: We first performed a whole transcriptome analysis through microarray (n=12: 4 CTRL; 4 mild NAFLD: NAS≤4 F0; 4 severe NAFLD NAS≥5 F3), followed by validation of selected transcripts through qPCRs in 88 subjects: 63 NAFLD, 25 CTRL. A similar analysis was also performed on HepG2 exposed to Oleate:Palmitate or only Palmitate (cellular model of NAFL/NASH) at intracellular/extracellular levels. Tran…
408 Phase I, first-in-human trial evaluating BI 1387446 (stimulator of interferon genes [STING] agonist) alone and combined with BI 754091 (anti-prog…
2020
Background Activation of the STING pathway in intratumoral immune cells leads to increased type I interferon production, promoting recruitment and priming of T-cells against tumor antigens, and providing anti-tumor activity.1 Intratumoral administration of STING agonists has resulted in notable therapeutic activity in animal models.1 STING agonists have also shown clinical activity in patients, which was more pronounced when combined with an anti-PD-1 antibody.2,3 BI 1387446 potently and highly selectively activates the STING pathway; BI 754091 is a humanized IgG4 anti-PD-1 monoclonal antibody. Intratumoral administration of BI 1387446 resulted in tumor regression, and enhanced the activity…
More restrictive Gray codes for necklaces and Lyndon words
2008
In the last years, the order induced by the Binary Reflected Gray Code or its generalizations shown an increasing interest. In this note we show that the BRGC order induces a cyclic 2-Gray code on the set of binary necklaces and Lyndon words and a cyclic 3-Gray code on the unordered counterparts. This is an improvement and a generalization to unlabeled words of the result in [V. Vajnovszki, Gray code order for Lyndon words, Discrete Math. Theoret. Comput. Sci. 9 (2) (2007) 145-152; M. Weston, V. Vajnovszki, Gray codes for necklaces and Lyndon words of arbitrary base, Pure Mathematics and Applications/Algebra and Theoretical Computer Science, in press]; however an algorithmic implementation …
Temperature Cues Bias the Memory of Trustworthiness of Faces
2016
Humans rely on temperature cues to navigate and make sense of their social world. In two experiments we find that part of this process can be detected in the perception and memory of faces. We conducted two studies to find this effect through a method called “reverse correlation”, where we average a face over a large amount of trials. For participants who experienced physical warmth (vs. cold) at the initial confrontation with a face we found that the average of the trials displayed a psychologically warmer face (judged by independent raters). Excluding the possibility of a “carry-over” effect, in Study 2 we replicated the Study 1 effect, but only if physical warmth (vs. cold) preceded the …
Optical CDMA enhanced by nonlinear optics
2010
Intended for the next generation of optical access networks, OCDMA is of great interest to meet the demand of increasing the number of users per access fiber, especially as spectral phase coding increases its performance in the optical domain. This, however, requires handling broad spectra and short pulses, which are best dealt with using opto-electronic or all-optical devices instead of slower electronics. Among others, we demonstrate spectral-phase-coded OCDMA using a fiber-based saturable absorber as thresholding in the receiver.
Spectral Slicing of a Supercontinuum Source for WDM/DS-OCDMA Application
2008
WDM and optical CDMA are leading contenders to easily upgrade access network performances in terms of multiple access technique. Both methods can be used at once, using a single multiwavelength optical source. We show, numerically and experimentally, that spectral slicing of a 10-GHz pulse train broadened to a supercontinuum yields pulses suitable for use in a direct sequence optical CDMA system. Simulations with optical CDMA encoders and decoders based on superstructured fiber Bragg gratings indicate good performance can be expected.
Spatial information transmission using axial temporal coherence coding
2007
We present an approach that can be used for transmission of information through space-limited systems or for superresolution. The spatial information is coded with different axial temporal coherence by interfering every spatial region in the input with the same region, but with a certain known delay in the longitudinal axis. Every spatial region has different delay. After mixing all of the spatial information, it is transmitted through the space-limited system. At the detection the information is passed through a similar interference setup containing certain axial delay. By temporally scanning along the longitudinal axis, each time a different spatial region that was coded with the correspo…
Joint Power Allocation and Link Selection for Multi-Carrier Buffer Aided Relay Network
2019
In this paper, we present a joint power allocation and adaptive link selection protocol for an orthogonal frequency division multiplexing (OFDM)-based network consists of one source node i.e., base station (BS), one destination node i.e., (MU) and a buffer aided decode and forward (DF) relay node. Our objective is to maximize the average throughput of the system via power loading over different subcarriers at source and relay nodes. A separate power budget is assumed at each transmitting node to make the system more practical. In order to form our solution more tractable, a decomposition framework is implemented to solve the mixed integer optimization problem. Further, less complex suboptim…
Distributed Resource Allocation for Energy Efficiency in OFDMA Multicell Networks with Wireless Power Transfer
2019
In this paper, an energy-efficient resource allocation problem is investigated for the wireless power transfer (WPT)-enabled OFDMA multicell networks. In the considered system, multiple base stations (BSs) with a large number of antennas are responsible to provide WPT in the downlink, and the users can recycle and utilize the received energy for uplink data transmission. The role of BS is to execute WPT; thus, there are no data transmissions in the downlink. A time-division protocol is considered to divide the time of downlink WPT and uplink wireless information transfer into separate time slots. With the objective to improve the energy efficiency, we propose the time, subcarrier, and power…