Search results for "COD"
showing 10 items of 2985 documents
Moderate-to-Strong Turbulence Generation in a Laboratory Indoor Free Space Optics Link and Error Mitigation via RaptorQ Codes
2016
Free Space Optics (FSO) is rapidly gaining interest as a line-of sight communication technology that offers capabilities similar - in terms of bandwidth and transfer rates - to optical fibre, also possessing several advantages compared with traditional radio frequency links. However, FSO link quality can be strongly affected by unfavourable weather conditions and also by the phenomenon of optical turbulence, even in clear sky. In this work, we have implemented an indoor FSO link and generated moderate-to-strong turbulence conditions along the optical path by using heaters and a mechanical ventilation system. In this way, we have been able to investigate the effects of the generated turbulen…
Rateless Codes Performance Tests On Terrestrial FSO Time-Correlated Channel Model
2012
Free Space Optics (FSO) links are affected by several impairments: optical turbulence, scattering, absorption, and pointing. In particular, atmospheric optical turbulence generates optical power fluctuations at the receiver that can degrade communications with fading events, especially, in high data rate links. A way to mitigate FSO link outages can be to add a coding to communications. Nevertheless, in order to study innovative solutions (software or hardware) and to improve the FSO link performance it needs accurate testing models. In this paper we describe an accurate time-correlated channel model able to predict random temporal fluctuations of optical signal irradiance caused by optical…
Upwind Relativistic MHD Code for Astrophysical Applications
2003
We describe the status of devolpment of a 2.5D numerical code to solve the equations of ideal relativistic magnetohydrodynamics. The numerical code, based on high-resolution shock-capturing techniques, solves the equations written in conservation form and computes the numerical fluxes using a linearized Riemann solver. A special procedure is used to force the conservation of magnetic flux along the evolution.
A Divergence-Free High-Resolution Code for MHD
2001
We describe a 2.5D numerical code to solve the equations of ideal magnetohydrodynamics (MHD). The numerical code, based on high-resolution shock-capturing (HRSC) techniques, solves the equations written in conservation form and computes the numerical fluxes using a linearized Riemann solver. A special procedure is used to force the conservation of magnetic flux along the time.
Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice
2020
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based pharmacokinetic/pharmacodynamic (PBPK-PD) model of MBQ-167 to predict tumor growth inhibition following intraperitoneal (IP) administration in mice bearing Triple Negative and HER2+ mammary tumors. PBPK and Simeoni tumor growth inhibition (TGI) models were developed using the Simcyp V19 Animal Simulator. Our developed PBPK framework adequately describes the time course of MBQ-167 in each of the mo…
The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells
2007
The human PVT-1 gene is located on chromosome 8 telomeric to the c-Myc gene and it is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. It has been proposed that PVT-1 regulates c-Myc gene transcription over a long distance. To get new insights into the functional relationships between the two genes, we have investigated PVT-1 and c-Myc expression in normal human tissues and in transformed cells. Our findings indicate that PVT-1 expression is restricted to a relative low number of normal tissues compared to the wide distribution of c-Myc mRNA, whereas the gene is highly expressed in many transformed cell types including neuroblastom…
Evidence for involvement of a nuclear envelope-associated RNA helicase activity in nucleocytoplasmic RNA transport
1990
It seems well established that translocation of at least some mRNAs through the nuclear pore is (1) an energy-dependent process, and (2) dependent on the presence of the poly(A) segment attached to most mRNA species. We describe that RNA helicase (RNA duplex unwindase) activity is present in a nuclear envelope (NE) preparation, which also appears to be involved in nucleocytoplasmic RNA transport. This activity unwinds RNA: RNA hybrids. The helicase has a pH optimum of 7.5 and a temperature optimum of 30 degrees C. Applying the sealed NE vesicle system, it was shown that duplex RNA species are readily released from the vesicles in an unidirectional manner, in contrast to single-stranded RNA,…
Breaking the temperature-size rule: Thermal effects on growth, development and fecundity of a crustacean from temporary waters
2013
The temperature-size rule (TSR) is a well-established phenomenon to describe the growth response of ectotherms to temperature by which individuals maintained at low temperatures grow more slowly, but attain a larger size upon maturity. Although there are adaptive and non-adaptive theories about the plasticity of body size in response to temperature, these cannot be applied to all ectotherms, and little is known about the changes in growth and development rates through ontogeny. The ostracod species Heterocypris bosniaca, an inhabitant of freshwater temporary ponds, was used to examine the growth and development rates of its nine growth stages and female fecundity at four different temperatu…
Release of Hypoacetylated and Trimethylated Histone H4 Is an Epigenetic Marker of Early Apoptosis
2006
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Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
2021
Tsetse flies are vectors of parasitic African trypanosomes, the etiological agents of human and animal African trypanosomoses. Current disease control methods include fly-repelling pesticides, fly trapping, and chemotherapeutic treatment of infected people and animals. Inhibiting tsetse’s ability to transmit trypanosomes by strengthening the fly’s natural barriers can serve as an alternative approach to reduce disease. The peritrophic matrix (PM) is a chitinous and proteinaceous barrier that lines the insect midgut and serves as a protective barrier that inhibits infection with pathogens. African trypanosomes must cross tsetse’s PM in order to establish an infection in the fly, and PM struc…