Search results for "COLON"
showing 10 items of 2038 documents
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
2014
Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal …
Carga y factores de riesgo para la neumonía adquirida en la comunidad de Pseudomonas aeruginosa : un estudio multinacional de prevalencia puntual de …
2018
Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeru…
“Podalirius” o “Polidarius”? Da Arrigo da Settimello a Guido delle Colonne
2016
This paper is dedicated to the defence of the variant "Polidarius" (and not the correction in the vulgate "Podalirius") that occurs in all the manuscripts of Henry of Septimello's «Elegia» (book IV, line 209). "Polidarius", however, has many attestations in Medieval Troy literary tradition (Joseph of Exeter, Benoît de Sainte-Maure, Guido delle Colonne) and is an alternative, correct and good name for the famous mythical doctor, son of Asclepius and brother of Machaon.
Early modern state formation in the margins? A review of early modern popular politics and limited royal power in the Polish-Lithuanian Commonwealth …
2017
The traditional historiography of early modern state-building has usually followed the western European paradigm of historiography, the usual models being France, England, Brandenburg-Prussia and Sweden. Regions that do not follow this paradigm have simply been left out and labeled “backward” or as “lagging behind”. In this literary review, our focus is on two different and rather surprising cases of early modern state formation: the Polish-Lithuanian Commonwealth and the Spanish colonial empire in Latin America. By following the scholarship on these two large conglomerates, we focus on two scholarly concepts: the idea of early modern realms as composite/conglomerate states, and state forma…
Biodegradable and pH-sensitive hydrogels for potential colon-specific drug delivery: Characterization and in vitro release studies
2008
A novel pH-sensitive and biodegradable composite hydrogel, based on a methacrylated and succinic derivative of dextran, named Dex-MA-SA, and a methacrylated and succinic derivative of alpha,beta-poly( N-2-hydroxyethyl)- DL-aspartamide (PHEA), named PHM-SA, was produced by photocross-linking. The goal was to obtain a colon-specific drug delivery system, exploiting both the pH-sensitive behavior and the colon-specific degradability. The hydrogel prepared with a suitable ratio between the polysaccharide and the polyaminoacid was characterized regarding its swelling behavior in gastrointestinal simulated conditions, chemical and enzymatic degradability, interaction with mucin, and cell compatib…
Distributed learning automata-based scheme for classification using novel pursuit scheme
2020
Learning Automata (LA) is a popular decision making mechanism to “determine the optimal action out of a set of allowable actions” (Agache and Oommen, IEEE Trans Syst Man Cybern-Part B Cybern 2002(6): 738–749, 2002). The distinguishing characteristic of automata-based learning is that the search for the optimising parameter vector is conducted in the space of probability distributions defined over the parameter space, rather than in the parameter space itself (Thathachar and Sastry, IEEE Trans Syst Man Cybern-Part B Cybern 32(6): 711–722, 2002). Recently, Goodwin and Yazidi pioneered the use of Ant Colony Optimisation (ACO) for solving classification problems (Goodwin and Yazidi 2016). In th…
Personāži ar hibrīdu identitātēm Amitava Goša un Salmana Rušdi romānos
2017
Šis maģistra darbs analizē personāžu hibrīdu identitātes un to savdabīgās balsis Salmana Rušdi un Amitava Goša romānos. Darba teorētiskā daļa ir balstīta uz krievu filozofa Mihaila Bahtina teorijām par heteroglosiju un polifoniju romānos, kā arī Edvarda Saida, Homi Babas, Roberta Janga un citu filozofu teorijām par koloniālismu, migrāciju, diasporām un hibriditāti. Darba praktiskā daļa izmeklē personāžu hibrīdu identitātes Salmana Rušdi un Amitava Goša romānos – “Magoņu jūra”, “Pusnakts bērni”, “Zeme zem viņas kājām” un “Maura pēdējā nopūta”. Pētījums pierāda, ka Amitavs Gošs un Salmans Rušdi meistarīgi iekļauj hibriditāti savos romānos, katram personāžam piešķirot specifisku un unikālu ide…
What is the best surgical option for the resection of transverse colon cancer?
2019
Transverse colon is an infrequent localization of colon cancer and it is burdened by a poor prognosis. The principle of oncological radicality includes primary tumor resection with adequate lymphadenectomy. To date, there is still no consensus on which type of surgical resection perform in case of transverse colon cancer (TCC). Lymphatic drainage and vascularization of this section of the colon is highly variable presenting with different anatomical variants. Moreover, mobilization of the transverse colon can be particularly challenging in comparison to other colon tracts. Despite a lack of standardized definitions, three main surgical options are proposed: segmental colectomy of the transv…
Mould germination: data treatment and modelling.
2006
Abstract The objectives of this study were i/ to examine germination data sets over a range of environmental conditions (water activity, temperature) for eight food spoilage moulds, ii/ to compare the ability of the Gompertz equation and logistic function to fit the experimental plots, iii/ to simulate germination by assessing various distributions of the latent period for germination amongst a population of spores. Data sets (percentage germination, P (%), versus time, t) of Aspergillus carbonarius, Aspergillus ochraceus, Fusarium verticillioides, Fusarium proliferatum, Gibberella zeae, Mucor racemosus, Penicillium chrysogenum and Penicillium verrucosum were analysed. No correlation, or re…
Between-population Similarity in Intestinal Parasite Community Structure of Pike (Esox Lucius)—Effects of Distance and Historical Connections
2009
The effect of geographical distance on similarity in parasite communities of freshwater fish has received considerable attention in recent years, and it has become evident that these apparently simple relationships are influenced by, among other things, colonization ability of parasites and degree of connectivity between the populations. In the present paper, we explored qualitative and quantitative similarity in the intestinal parasite communities of pike (Esox lucius) in a particular system where previously interconnected groups of lakes became isolated ca. 8,400 yr ago. Contrary to our expectations, we did not find differences in similarity between the lake groups or a negative effect of…