Search results for "COLUMN"
showing 10 items of 1301 documents
Determination of the enantiomeric composition of amphetamine, methamphetamine and 3,4-methylendioxy-N-methylamphetamine (MDMA) in seized street drug …
2021
Amphetamine (speed), methamphetamine (crystal meth), and 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) represent the most frequently abused amphetamine-type stimulants (ATS). Differences in pharmacological potency and metabolism have been shown for the enantiomers of all three stimulants. Legal consequences in cases of drug possession may also differ according to the German law depending on the enantiomeric composition of the seized drug. Therefore, enantioselective monitoring of seized specimens is crucial for legal and forensic casework. Various kinds of samples of amphetamine (n = 143), MDMA (n = 94), and methamphetamine (n = 528) that were seized in southern Germany in 2019 and…
Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spe…
2004
Abstract An automated HPLC method with column switching is described for the determination of quetiapine, clozapine, perazine, olanzapine and metabolites in blood serum. After clean-up on silica C8 material (20 μm particle size) drugs were separated on ODS Hypersil C18 material (5 μm; column size 250 mm × 4.6 mm i.d.) within 25 min and quantified by ultraviolet (UV) detection at 254 nm. The limit of quantification ranged between 10 and 50 ng/ml. At therapeutic concentrations of the drugs, the inter-assay reproducibility was below 10%. Analyses of drug concentrations in serum of 75–295 patients treated with therapeutic doses of the antipsychotic drugs revealed mean ± S.D. steady state concen…
Adsorption of Db and its homologues Nb and Ta, and the pseudo-homologue Pa on anion-exchange resin in HF solution
2009
Anion-exchange chromatography of element 105, dubnim (Db), produced in the 206 Cm( 19 F, 5n) 262 Db reaction is investigated together with the homologues Nb and Ta, and the pseudo-homologue Pa in 13.9 M hydrofluoric acid (HF) solution. The distribution coefficient (K d ) of Db on an anion-exchange resin is successfully determined by running cycles of 1702 chromatographic column separations. The result clearly indicates that the adsorption of Db on the resin is significantly different from that of the homologues and that the adsorption of anionic fluoro complexes of these elements decreases in the sequence of Ta ≈ Nb > Db > Pa.
A computational study of LP-based heuristic algorithms for two-dimensional guillotine cutting stock problems
2002
In this paper we develop and compare several heuristic methods for solving the general two-dimensional cutting stock problem. We follow the Gilmore-Gomory column generation scheme in which at each iteration a new cutting pattern is obtained as the solution of a subproblem on one stock sheet. For solving this subproblem, in addition to classical dynamic programming, we have developed three heuristic procedures of increasing complexity, based on GRASP and Tabu Search techniques, producing solutions differing in quality and in time requirements. In order to obtain integer solutions from the fractional solutions of the Gilmore-Gomory process, we compare three rounding procedures, rounding up, t…
In-Depth Analysis of Pricing Problem Relaxations for the Capacitated Arc-Routing Problem
2015
Recently, Bode and Irnich [Bode C, Irnich S (2012) Cut-first branch-and-price-second for the capacitated arc-routing problem. Oper. Res. 60(5):1167–1182] presented a cut-first branch-and-price-second algorithm for solving the capacitated arc-routing problem (CARP). The fundamental difference to other approaches for exactly solving the CARP is that the entire algorithm works directly on the typically sparse underlying graph representing the street network. This enables the use of highly efficient dynamic programming-based pricing algorithms to solve the column-generation subproblem also known as the pricing problem. The contribution of this paper is the in-depth analysis of the CARP pricing…
Effective Handling of Dynamic Time Windows and Its Application to Solving the Dial-a-Ride Problem
2015
A dynamic time window relates to two operations that must be executed within a given time meaning that the difference between the points in time when the two operations are performed is bounded from above. The most prevalent context of dynamic time windows is when precedence is given for the two operations so that it is a priori specified that one operation must take place before the other. A prominent vehicle routing problem with dynamic time windows and precedence is the dial-a-ride problem (DARP), where user-specified transportation requests from origin to destination points must be serviced. The paper presents a new branch-and-cut-and-price solution approach for the DARP, the prototypi…
The response of calcareous nannoplankton to sea surface variability at Ceara Rise during the early Pleistocene glacial-interglacial cycles
2019
The Ceara Rise lies just beyond the edge of the Amazon River Fan and sediments from this site may record the complex interplay of different climatic systems and processes, including past changes in southern America monsoon activity, Intertropical Convergence Zone setting, different Atlantic Meridional Overturning Circulation (AMOC) strength and phytoplankton blooming triggered by Amazon River plumes. Here we investigate early Pleistocene calcareous nannoplankton at Ceara Rise, between about 1150 and 850 kiloyears ago. Our investigation shows abrupt variations in water column dynamics across glacial/interglacial cycles or, even better, linked with different AMOC modes. Dominant placoliths in…
Seismic behavior of exterior RC beam-column joints without code-specified ties in the joint core
2021
Abstract Beam-column joint design for reinforced concrete (RC) buildings is a critical issue for modern earthquake engineering, because for these structural elements, the current codes provide several geometrical constraints and reinforcement provisions, which may be very complex to implement during the construction phase. To investigate how a construction error might influence the joint behavior, two identical full-scale exterior beam-column joints specimens are built, according to Italian Building Code specifications for the high ductility class, but without the required horizontal ties inside the joint panel. This construction error could be plausible because, according to the design dra…
Night, day, sunrise, sunset: do fish under snow and ice recognize the difference?
2008
1. Although boreal lakes are ice-covered for several months annually, little is known about the behaviour of fish under ice. To consider the reasons for diel vertical migrations (DVM) it is important to compare periods under ice as opposed to under open water. Echosounding provides a tool for non-intrusive continuous monitoring of fish, even in winter. 2. Changes in the vertical distribution of fish through six 48-h periods were monitored using a stationary, mounted echosounder that beamed vertically either from the bottom up or from the surface down from February to April, 2003. The up-beaming and down-beaming transducers were run alternately for 24 h each over the 48-h period. Standard ec…