Search results for "COM.E.TA."
showing 10 items of 198 documents
Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures
2015
We are pleased to note that our publication “Comparison of spike parameters from optically identified GABAergic and glutamatergic neurons in sparse cortical cultures” by Weir et al. (2015) raised some discussion on the feasibility of solely electrophysiological discrimination of distinct neuronal subpopulations in vitro. We agree with Becchetti and Wanke (2015) that their report and our study on the same question were conducted with different technical approaches and that this may explain the observed differences between both studies. Although we obviously recorded a reduced spontaneous neuronal activity under our sparse culture conditions, these conditions were necessary to enable the uneq…
Commentary: "Nitric oxide releases Cl(-) from acidic organelles in retinal amacrine cells".
2015
In their recent article (Krishnan and Gleason, 2015) Vijai Krishnan and Evanna Gleason investigate the cellular mechanisms underlying the shift in the GABA reversal potential upon application of nitric oxide (NO). Functional alteration in GABAergic signaling by alterations in the GABA reversal potential has been identified as an important mechanism of plasticity (Raimondo et al., 2012) and NO is clearly one key substance involved in plasticity (Prast and Philippu, 2001). Therefore, the investigation of the mechanisms behind the NO induced shift in GABAergic effects is an important issue. However, in my opinion the authors neglected a possible explanation of their observations in the discuss…
On the divide between animate and inanimate
2015
Vitalism was abandoned already for a long time ago, yet the impression that animate beings differ in some fundamental way from inanimate objects continues to thrive. Here, we argue that scale free patterns, found throughout nature, present convincing evidence that this demarcation is only imaginary. Therefore, all systems ought to be regarded alike, i.e., all are consuming free energy in least time. This way evolutionary processes can be understood as a series of changes from one state to another, so that flows of energy themselves naturally select those ways and means, such as species and societies or gadgets and galaxies to consume free energy in the least time in quest of attaining therm…
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
2004
Alzheimer disease (AD) is characterized by excessive deposition of amyloid beta-peptides (A beta peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the alpha-secretase within the A beta peptide sequence. Proteinases of the ADAM family (adisintegrin and metalloproteinase) are the main candidates as physiologically relevant alpha-secretases, but early lethality of knockout animals prevented a detailed analysis in neuronal cells. To overcome this restriction, we have generated transgenic mice that overexpress either ADAM10 or a catalytically inactive ADAM10 mutant. In this report we show that a moderate neuronal overexpression of ADAM10 i…
Reconsidering authorship in the Ciceronian corpus through computational authorship attribution
2019
In recent years, methods of computational authorship attribution have offered promising results for the reattribution of classical texts. We use and further develop these methods to verify the authorship of several texts belonging or related to the Ciceronian corpus: Rhetorica ad C. Herennium, De inventione, De optimo genere oratorum, and Commentariolum petitionis. We use two classifiers, Support Vector Machine and Convolutional Neural Network, of which the latter is more accurate except in regard to certain aspects of vocabulary. The most important of our results is that Commentariolum petitionis seems to be authored by Marcus Cicero, not by his brother Quintus. Negli ultimi anni metodi co…
An Integrated Approach for the Valorization of Cheese Whey
2021
Taking into account the large amount of whey that is produced during the cheese production process and the constant demand by society for more sustainable processes, in accordance with Sustainable Development Goals (SDGs) and the circular economy concept, it is necessary to adapt two-unit operations into a single process, allowing us to not only valorize a part of the whey but the whole process, which is known as bioprocess integration. In this sense, the adaptation of different processes, for example, physicochemical (micro, ultra and nanofiltration) and fermentation, that are commonly used to obtain proteins, lactose and other compounds with different activities (antioxidant, antifungal, …
Studi sui commentarii 'istituzionali' di Gaio: formazione e natura del testo, vol. 01
2022
The only classical jurisprudential text to have come down to us, in its entirety, without the mediation and filter of the Justinian Digest, Gaius's commentaries from the famous Codex Veronensis no. 13 - commonly referred to as institutiones, but perhaps not by their author - present such characters and writing techniques as to be recognised as an isagogical text that the jurist-teacher must have composed (around the middle of the 2nd century AD, reigning Antoninus Pius) as a teaching aid intended to circulate exclusively among the circle of his students. The peculiarities of the compositional strategy suggest an original and direct Gaian authorship, freeing the work from a consolidated cons…
The prohibition of commentaries to the Digest and the antecessorial literature
2014
Esaminate e criticate le diverse interpretazioni presenti in storiografia, si propone una nuova lettura del divieto giustinianeo di commentari al Digesto, che postula il divieto come avente ad oggetto il Digesto quale testo da usare nei tribunali e non quale testo oggetto di studio. Conseguentemente, i destinatari del divieto non erano gli antecessores, come finora unanimemente ritenuto: il che rende perfettamente giustificabile e non in contrasto col divieto la presenza di una ricca produzione di commentari derivanti dall'attività di insegnamento.
Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study
2021
Abstract Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of…