Search results for "COMB"

Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.

2007

Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…

A new method to value efficiency of enzyme blends for pancreatic tissue digestion.

2010

Islet transplantation, since the 90’s, has been resulting to be one of the best successful example of human cell therapy. Nevertheless, islet isolation procedure is not completely standardized; in fact, more than fifty percent of islets procedures don’t arrive to their transplantation. This is due both to the variability of donor’s pancreas and to an unpredictable enzymatic blend efficiency. Enzymes used in pancreas digestion are extracted from Clostridium histolyticum bacteria and digest several substrates. In particular they have strong collagenolytic activity compared to vertebrate collagenases. However, several impediments persist in human islet isolation success probably due to the var…

A Novel Long-Term Graves’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies

2020

<b><i>Introduction:</i></b> A novel long-term murine model for Graves’ disease (GD) using repeated, long-term immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human thyrotropin receptor (Ad-TSHR) was applied to evaluate the functional anti-TSHR-antibody (TSHR-Ab) profile. <b><i>Methods:</i></b> BALB/c mice received 7 immunizations with either 10<sup>10</sup> plaque-forming units of Ad-TSHR or control Ad-GFP. Naïve (nonimmuized native) mice were also studied. Three 3-weekly immunizations were followed by 4-weekly boosts until the 7th immunization. Blocking (TBAb) and stimulating (TSAb) TSHR-Ab …

Acute neuromuscular, cardiorespiratory and endocrine responses and chronic adaptations to combined strength and endurance training in recreationally …

2013

Topological surface wave metamaterials for robust vibration attenuation and energy harvesting

2021

International audience; We propose topological metamaterials working in Hertz frequency range, constituted of concrete pillars on the soil ground in a honeycomb lattice. Based on the analog of the quantum valley Hall effect, a non-trivial bandgap is formed by breaking the inversion symmetry of the unit cell. A topological interface is created between two different crystal phases whose robustness against various defects and disorders is quantitatively analyzed. Finally, we take advantage of the robust and compact topological edge state for designing a harvesting energy device. The results demonstrate the functionality of the proposed structure for both robust surface vibration reduction and …

Pila de combustible de hidrógeno. La apuesta por una energía sostenible

2012

El objetivo de este trabajo es mostrar diferentes aplicaciones de una pila de combustible de hidrógeno como acumulador de energía. Para fabricar la pila de hidrógeno en primer lugar se cortan los tubos de metacrilato y se reparten en la posición que tendrían en la pila, y con esas medidas se marcan y se cortan las dos placas de metacrilato. Posteriormente se pegan los tubos anchos en su lugar mediante pegamento termofusible y se comprueba su estanqueidad. Tras reparar las fugas, se señala sobre la otra placa de metacrilato la posición de los tubos finos, y se pegan en su lugar correspondiente, probando a cada tubo pegado si las dos partes de la pila encajan correctamente. Las celdas de comb…

Determinación experimental del equilibrio entre fases de sistemas azeotrópicos relacionados con biocombustibles. Selección de entrainers de bajo impa…

2016

El problema del calentamiento global hace indispensable plantear alternativas que permitan llevar a cabo una transición desde el actual sistema energético basado en combustibles fósiles hacia otro en el que tengan mayor presencia las llamas energías “limpias” o renovables. De entre todas ellas, el uso de biocombustibles es una de las opciones más atractivas y con un estado de desarrollo más avanzado. Sin embargo, aún existen una serie de problemas tecnológicos, como por ejemplo la deshidratación de los biocombustibles basados en el bioetanol y biopropanol, pues al tratarse de mezclas azeotrópicas el agua que contienen no puede eliminarse mediante destilación convencional. En este sentido, e…

A formula for the Euler characteristic of $\overline{{\cal M}}_{2,n}$

2001

In this paper we compute the generating function for the Euler characteristic of the Deligne-Mumford compactification of the moduli space of smooth n-pointed genus 2 curves. The proof relies on quite elementary methods, such as the enumeration of the graphs involved in a suitable stratification of \(\overline{{\cal M}}_{2,n}\).

The effects of a 10-week combined maximal and explosive strength and high-intesity endurance training period on neuromuscular performance and 3K time…

2015

Combined strength and endurance training has been noted to produce significant improvements in strength and endurance performances in both men and women. However, there seems to be moderate inhibitory effect regarding strength adaptations, especially considering power production. This study was conducted to investigate the effects of a 10-week combined maximal and explosive strength and high-intensity endurance training period on neuromuscular performance and 3K time-trial in males and females. A total of 19 healthy recreationally trained subjects (Males: M= 10, Females: F= 9) completed a 10-week combined strength and endurance training period. All subjects trained twice a week strength and…

Integrin-mediated Cell Adhesion to Type I Collagen Fibrils

2004

In the integrin family, the collagen receptors form a structurally and functionally distinct subgroup. Two members of this subgroup, α1β1 and α2β1 integrins, are known to bind to monomeric form of type I collagen. However, in tissues type I collagen monomers are organized into large fibrils immediately after they are released from cells. Here, we studied collagen fibril recognition by integrins. By an immunoelectron microscopy method we showed that integrin α2I domain is able to bind to classical D-banded type I collagen fibrils. However, according to the solid phase binding assay, the collagen fibril formation appeared to reduce integrin α1I and α2I domain avidity to collagen and to lower …