Search results for "COMPLEX"
showing 10 items of 5889 documents
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…
El edificio gremial de los abaixadors o tundidores, en Valencia
2020
In the ?barri del mercat?, in the city of Valencia and very close to its Lonja, there is a building complex which is the object of this study. The research, carried out from the simple field of toponymy, to the constructive analysis, lead us to suppose that it is the building of the Valencian trade union of cloth-shearers. It can be seen how the building now camouflaged by other subsequent interventions, corresponds to a type that cannot be related to those usually built in the city of Valencia. Its origins clearly from the Valencian self-governing period splendor, its dimensions and the finishes used in its construction seem to refer to a medieval workshop. A structure of great importance …
Thermal anomalies detection in a photovoltaic plant using artificial intelligence: Italy case studies
2021
This paper proposes the application of artificial intelligence techniques for the identification of thermal anomalies that occur in a photovoltaic system due to malfunctions or faults, with the aim to limit the energy production losses by detecting faults at an early stage. The proposed approach is based on a Thermographic Non-Destructive Test conducted with Unmanned Aerial Vehicles equipped with a thermal imaging camera, which allows the detection of abnormal operating conditions without interrupting the normal operation of the PV system rapidly and cost-effectively. The thermographic images and videos are automatically inspected using a Convolutional Neural Network, developed by an open-s…
Modèles de comportements collectifs et coopératifs
2012
Le choix résidentiel est considéré comme un acte individuel ou celui d'un " mini-groupe " (famille) qui est conditionné par des références collectives. De ce fait, il s'appuie sur des informations (renommée de quartiers, d'une école, accessibilité à des services, commerces ...) mais il contribue également à l'émergence de tendances (préférence de certains modes de vie et de quartiers ...) qui peuvent être à l'origine de flux migratoires. Ces derniers participent à l'émergence de nouvelles configurations spatiales à l'échelle d'une ville, donc de phénomènes macroscopiques. De telles tendances sont donc le résultat d'interactions entre individus et groupe sociaux, entre individus et société, …
Measuring syntactic complexity in learner Finnish
2020
In the study of complexity, accuracy and fluency (CAF), syntactic complexity can be measured by a multitude of measures. Traditionally, the measures are quantitative and they use production units such as words, clauses, T -units, and sentences. Despite the vast number o f measures available, many studies have used only one or two of them, or parallel ones tapping the same component of complexity. The present study explores syntactic complexity using seven frequently used quantitative complexity measures to gauge different facets of complexity in written learner Finnish. The data of the study consist of texts written by adult and adolescent language learners, and they cover proficiency level…
Words, clauses, sentences, and T-units in learner language: Precise and objective units of measure?
2020
In research on learner language complexity, accuracy and fluency (CAF), syntactic complexity is often studied with quantitative measures based on words, clauses, sentences, and T-units. The findings have been mixed, but segmenting learner language into these units of measure has seldom been problematised, even if the need for accurate coding is well known. The present study explores words, clauses, sentences, and T-units as production units in written learner language using a corpus of 352 L2 Finnish texts (28,813 words). The results illustrate how written learner language can be hard to fit into the production unit categories, which are essential for the most frequently used quantitative m…
From conceptualization to constructions in Finnish as an L2 : a case study
2017
AbstractThis study traces the individual learning trajectories of an adult beginner L2 Finnish learner in expressing the extralinguistic concept of evaluation from a dynamic usage-based perspective. Our results provide support for the view of learner language as a dynamic system in which patterns wax and wane and in which a change in one component has the potential to affect the whole system. In the early stages of learning there was a strong preference to use lexical verbs first, and then adjectives. The study also shows that variability plays a role. Finally, the study confirms that the learning of L2 constructions is in some cases item based. However, another highly frequent and superfic…
Investigating Syntactic Complexity in EFL Learners' Writing across Common European Framework of Reference Levels A1, A2, and B1
2019
Abstract The study investigates the linguistic basis of Common European Framework of Reference (CEFR) levels in English as a foreign language (EFL) learners’ writing. Specifically, it examines whether CEFR levels can be distinguished with reference to syntactic complexity (SC) and whether the results differ between two groups of EFL learners with different first languages (Sindhi and Finnish). This sheds light on the linguistic comparability of the CEFR levels across L1 groups. Informants were teenagers from Pakistan (N = 868) and Finland (N = 287) who wrote the same argumentative essay that was rated on a CEFR-based scale. The essays were analysed for 28 SC indices with the L2 Syntactic Co…
Conjunctions and syntactic complexity: Development of the use of conjunctions in written learner Finnish
2022
Kielitaidon kehittymistä voidaan tutkia mittaamalla oppijankielen sujuvuutta, tarkkuutta ja kompleksisuutta. Kompleksisuus voidaan määritellä oppijankielen monipuolisuudeksi ja kehittyneisyydeksi, mutta syntaktista kompleksisuutta on kansainvälisessä toisen kielen oppimisen tutkimuksessa tyypillisesti mitattu alisteisiin lauserakenteisiin perustuvilla kvantitatiivisilla mittareilla. Tässä artikkelissa syntaktisen kompleksisuuden kehitystä tutkitaan tarkastelemalla rinnastus- ja alistuskonjunktioiden käyttöä suomi toisena kielenä -teksteissä Eurooppalaisen viitekehyksen eri taitotasoilla. Aineistona käytetään Jyväskylän yliopiston Cefling-hankkeen oppijansuomen korpuksen tekstejä. Rinnasteis…