Search results for "CONDITIONING"
showing 10 items of 632 documents
Efecto del ejercicio físico sobre las alteraciones cognitivas y el estrés oxidativo en un modelo transgénico APP/PSN1 para la enfermedad de Alzheimer
2012
Resumen Introduccion Los efectos beneficiosos del ejercicio fisico, tanto en el tratamiento como en la prevencion de distintas enfermedades, han sido ampliamente establecidos. La demencia mas frecuente, la enfermedad de Alzheimer (EA) es un trastorno donde el ejercicio ha demostrado causar notables mejoras fisiopatologicas y cognitivas. En el presente trabajo estudiamos el efecto del ejercicio fisico sobre el estres oxidativo y la cognicion en el modelo murino doble transgenico (2×Tg) para la EA, APP/PSN1, basado fundamentalmente en la deposicion cerebral de placas de β-amiloide. Material y metodos Dieciocho ratones de 10 meses de edad fueron divididos en 4 grupos experimentales: 2×Tg entre…
Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-…
2016
Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug. Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure. Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test. First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice. Then, HNS and LNS mice were pretreated i.p. with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently con…
Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference.
2009
The present study employs a conditioned place preference procedure (CPP) to examine the effects of exposure to the cannabinoid agonist WIN 55212-2 (WIN) (0.1 and 0.5mg/kg) during adolescence on the reinforcing properties of +/-3,4-methylenedioxymetamphetamine hydrochloride (MDMA) (1.25 and 2.5mg/kg) in mice. On postnatal day (PD) 27, animals received a daily injection of the assigned treatment on 5 consecutive days, and three days later the place conditioning procedure was initiated (PD 35). The results suggest that pre-exposure to cannabinoids strengthens the properties of MDMA and favors reinstatement of the craving for the drug, which endorses the gateway hypothesis.
CB1 cannabinoid receptor-mediated aggressive behavior
2013
This study examined the role of cannabinoid CB1 receptors (CB1r) in aggressive behavior. Social encounters took place in grouped and isolated mice lacking CB1r (CB1KO) and in wild-type (WT) littermates. Cognitive impulsivity was evaluated in the delayed reinforcement task (DRT). Gene expression analyses of monoaminooxidase-A (MAO-A), catechol-o-methyl-transferase (COMT), 5-hydroxytriptamine transporter (5-HTT) and 5-HT1B serotonergic receptor (5HT1Br) in the median and dorsal raphe nuclei (MnR and DR, respectively) and in the amygdala (AMY) were performed by real time-PCR. Double immunohistochemistry studies evaluated COMT and CB1r co-localization in the raphe nuclei and in the cortical (AC…
Energy-saving potential of ground source multiple chillers in simple and hybrid configurations for Mediterranean climates
2022
Air conditioning accounts for a large share of energy usage in residential and tertiary sectors. Renewable energy technologies offer promising solutions to reduce the environmental impacts of meeting buildings’ energy loads. The possibility of using the soil as a thermal reservoir for heating and cooling systems has gained growing attention in the last decade due to its high potential for energy saving. In this paper, the benefits achievable using ground source chillers for air conditioning in an office building located in Southern Italy are discussed. A multiple chillers system coupled with a borehole heat exchanger is investigated and compared to conventional air-cooled and water-cooled s…
Experimental characterization of variable-speed packaged rooftop units in presence of evaporator fouling
2022
Variable-speed packaged rooftop units have been increasingly adopted in the commercial sector. If not properly maintained, the fouling of heat exchangers and the improper refrigerant charge could increase energy consumption. In this work, the response of variable-speed rooftop units to evaporator fouling is investigated based on experiments on a variable-speed 17.5 kW rooftop unit. A novel testing procedure is proposed, aimed at covering a broad range of operating conditions by a reduced number of tests. Two opposite cases were investigated: (i) even in presence of fouling, the controller can restore the required cooling capacity, and (ii) the intensity of the fouling does not allow the con…
Adopting magnetocaloric heat pumping and refrigeration for electrical vehicle
2017
International audience; Refrigeration process is based on conventional gas compression and expansion techniques. However, this technique has numerous disadvantages since it generates greenhouse gas and is partly responsible for global warming. This paper exposes analternative method: magnetocaloric refrigeration that presents the advantage to combine high-energy efficiency and respect of theenvironment. Magnetic heat pumping and cooling is compared to conventional method applied on vehicle air conditioning system.Simulation results are used to demonstrate the approach.
Selective erasure of a fear memory
2009
International audience; Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning b…
Changes in sprint performance and sagittal plane kinematics after heavy resisted sprint training in professional soccer players
2019
Background Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic changes are unknown in a professional setting. Another unknown factor is whether violating kinematic specificity via heavy resistance will lead to changes in unloaded sprinting kinematics. We investigated whether heavy resisted sled training (HS) affects sprint performance, kinetics, sagittal plane kinematics, and spatiotemporal parameters in professional male soccer players.…