Search results for "CONDITIONING"
showing 10 items of 632 documents
Effects of extended cocaine conditioning in the reinstatement of place preference.
2008
Rats allowed extended access to cocaine self-administration develop a number of symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the conditioned place preference (CPP), the number of conditioning training sessions was increased in order to augment exposure to contextual cues associated with the effects of a drug. Mice were conditioned with a steady dose of 6 or 25 mg/kg of cocaine for 4, 8, 12, 16, 20 or 40 days. Weekly sessions of extinction followed the establishment of preference, after which a priming dose of cocaine was administered to reinstate the extinguished preference. The magnitude of the place preference effect was equal in all groups, indepen…
Post-remission treatment with allogeneic stem cell transplantation in patients aged 60 years and older with acute myeloid leukaemia: a time-dependent…
2015
Summary Background Acute myeloid leukaemia mainly affects elderly people, with a median age at diagnosis of around 70 years. Although about 50–60% of patients enter first complete remission upon intensive induction chemotherapy, relapse remains high and overall outcomes are disappointing. Therefore, effective post-remission therapy is urgently needed. Although often no post-remission therapy is given to elderly patients, it might include chemotherapy or allogeneic haemopoietic stem cell transplantation (HSCT) following reduced-intensity conditioning. We aimed to assess the comparative value of allogeneic HSCT with other approaches, including no post-remission therapy, in patients with acute…
Hs-cTnT levels in professional soccer players throughout a season: No evidence of sustained cardiac damage
2015
a Research Institute of the Hospital 12 de Octubre (“i + 12”), Madrid, Spain b Research Institute “Dr. Vina Giner”, Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Martir, Valencia, Spain c School of Medicine, Catholic University of Valencia San Vicente Martir, Valencia, Spain d Human Performance Laboratory, MAPEI Sport Research Center, Italy e Department of Physical Education and Sports, University of Valencia, Valencia, Spain f Laboratory of Experimental Biochemistry & Molecular Biology, I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy g Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy
Calcium and increase excitability promote tolerance against anoxia in hippocampal slices.
1999
We have previously demonstrated that anoxic preconditioning (APC) protects against a subsequent otherwise 'lethal' anoxic insult in hippocampal slices. Tested here are two hypotheses: (a) APC requires calcium to improve electrical recovery in hippocampal slices; and (b) mild excitation promotes preconditioning neuroprotection. Control hippocampal slices were given a single 'test' anoxic insult followed by reoxygenation. Experimental slices were preconditioned by three short anoxic insults of 1 min separated by 10 min of reoxygenation. At 30 min after the third 'conditioning' insult, slices underwent a 'test' anoxic insult [1 min of anoxic depolarization (AD)], and then slices were reoxygena…
Training-induced protection and effect of terminated training on exercise-induced damage and water content in mouse skeletal muscles.
1995
Muscle swelling in connection with training-induced protection against exercise-induced damage and the disappearance of the protective adaptation after termination of training was studied in male NMRI-mice, aged 8 weeks at the beginning of the experiment. Mice were randomly assigned to several different treatment groups (training, training-exercise, exercise, detraining, detraining-exercise, together with their respective controls). Training and prolonged exercise sessions were performed by running uphill (6 degrees) on a motor-driven treadmill. Muscle damage was estimated by the total activity of beta-glucuronidase and water content from the red parts of m. quadriceps femoris (MQF), m. sol…
Muscle Activity During Unilateral vs. Bilateral Battle Rope Exercises.
2015
High training intensity is important for efficient strength gains. Although battle rope training is metabolically demanding, no studies have quantified intensity of muscle activity during this type of training. This study analyzes muscle activity during unilateral alternating waves vs. bilateral waves of battle rope training. Twenty-one volunteers participated in a repeated-measures study on 2 different occasions. Surface electromyographic signals were recorded from the anterior deltoid (AD), external oblique (OBLIQ), lumbar erector spinae (LUMB), and gluteus medius (GM) during bilateral waves and unilateral waves and were normalized to the maximum voluntary isometric contraction (MVIC). Re…
Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training
2018
New Findings: What is the central question of this study? Can phenotypic traits associated with low response to one mode of training be extrapolated to other exercise-inducible phenotypes? The present study investigated whether rats that are low responders to endurance training are also low responders to resistance training. What is the main finding and its importance? After resistance training, rats that are high responders to aerobic exercise training improved more in maximal strength compared with low-responder rats. However, the greater gain in strength in high-responder rats was not accompanied by muscle hypertrophy, suggesting that the responses observed could be mainly neural in orig…
Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice.
2015
Bupropion is an antidepressant drug that is known to aid smoking cessation, although little experimental evidence exists about its actions on active avoidance learning tasks. Our aim was to evaluate the effects of this drug on two-way active avoidance conditioning. In this study, NMRI mice received bupropion (10, 20 and 40mg/kg) or saline before a daily training session (learning phase, days 1-4) in the active avoidance task. Performance was evaluated on the fifth day (retention phase): in each bupropion-treated group half of the mice continued with the same dose of bupropion, and the other half received saline. Among the vehicle-treated mice, different sub-groups were challenged with diffe…
Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction.
2010
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. Since amphetamine (Amph) and cocaine share mechanisms of action at the DAT, we evaluated the effectiveness of a BZT analog in animal models of Amph addiction. We tested in mice and rats the effects of the BZT derivative, 3α-[bis(4-fluorophenyl)methoxy]-tropane (AHN-1055), on Amph-induced conditioned place preference (CPP), locomotor activity, sensitization, self-administration and ΔFosB accumulation in th…
Training Load and Energy Expenditure during Military Basic Training Period
2019
Purpose: To compare training load and energy expenditure during an 8-week military BT period among individuals having different fitness level using objective measurements in an authentic environment. Methods: Thirty-four voluntary male conscripts (age 19.1±0.3 years) were divided into three training groups (inactive, moderate, active) by their reported physical activity (PA) level evaluated by the International Physical Activity Questionnaire (IPAQ) prior to military service. Maximal oxygen uptake (VO2max) and heart rate (HR) were determined by maximal treadmill test in the beginning and after 4 and 7 weeks of BT. During BT, HR monitors and accelerometers were used to measure PA and energy …