Search results for "CONSORT"
showing 10 items of 121 documents
Smoking and Helicobacter pylori infection: an individual participant pooled analysis (Stomach Cancer Pooling- StoP Project)
2019
Smoking has been associated with acquisition and increased persistence of Helicobacter pylori infection, as well as with lower effectiveness of its eradication. A greater prevalence of infection among smokers could contribute to the increased risk for gastric cancer. We aimed to estimate the association between smoking and seropositivity to H. pylori through an individual participant data pooled analysis using controls from 14 case- control studies participating in the Stomach Cancer Pooling Project. Summary odds ratios and prevalence ratios (PRs), adjusted for age, sex and social class, and the corresponding 95% confidence intervals (CIs) were estimated through random-effects meta-analysis…
Non-Hodgkin lymphoma and obesity: A pooled analysis from the InterLymph consortium
2008
Nutritional status is known to alter immune function, a suspected risk factor for non-Hodgkin lymphoma (NHL). To investigate whether long-term over, or under, nutrition is associated with NHL, self-reported anthropometric data on weight and height from over 10,000 cases of NHL and 16,000 controls were pooled across 18 case-control studies identified through the International Lymphoma Epidemiology Consortium. Study-specific odds ratios (OR) were estimated using logistic regression and combined using a random-effects model. Severe obesity, defined as BMI of 40 kg m-2 or more, was not associated with NHL overall (pooled OR = 1.00, 95% confidence interval (CI) 0.70-1.41) or the majority of NHL …
Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
2014
Background: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design. Methods: We pooled individual-level data from 20 case-control studies (17 471 NHL cases, 23 096 controls) from North Ame…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology
2015
Primary open-angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in two parts: a central cup (without nerve fibers) surrounded by the neuroretinal rim (containing axons of the retinal ganglion cells). The International Glaucoma Genetics Consortium conducted a meta-analysis of genome-wide association studies consisting of 17,248 individuals of European ancestry and 6,841 individuals of Asian ancestry. The outcomes of the genome-wide association studies were disc area and cup area. These specific measurements describe optic nerve morphology in another way than the vertical cup-disc ratio, …
Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases.
2018
Background: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways. Objectives: The goal was to find intermediate metabolites or metabolic pathways that could be associated with both air pollutants and health outcomes (“meeting-in-the-middle”), thus shedding light on mechanisms and reinforcing causality. Methods: We applied a statistical approach named ‘meet-in-the-middle’ to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases (CCVD). We compared the results …
Enquête sur les archives ouvertes françaises menée par Couperin en 2019 : résultats et analyses
2020
French Higher Education Institutions (HEIs) are, for 89% of the respondents to the survey, now having their own open repository, or declaring to be in the implementation phase (compared to 82% in 2017 and only 62% in 2014). It can therefore be considered that almost all HEIs now offer a green open access repository or signalling solution to their researchers. The « still in progress » or suspended projects are rather related to the current recomposition of the Higher Education landscape. The most obvious obstacles to the latest implementations remain both the low involvement of researchers in the project and the human resources allocated. There is a slight but real increase in the rate of i…
Enquête Archives Ouvertes COUPERIN 2017 : résultats de l’enquête
2017
Les archives ouvertes s’inscrivent de plus en plus solidement et durablement dans le paysage documentaire de l’enseignement supérieur. Si les organismes de recherche ont été précurseurs pour la création d’archives ouvertes, les grandes écoles, mais surtout les universités ont désormais massivement rejoint le mouvement. Signe de cette progression notable, 82 % des répondants disposent en 2017 d’une archive en production ou en cours de mise en œuvre, contre 62 % en 2014. L’adoption majoritaire de la plate-forme HAL (qui représente 79 % des archives en production et 84 % des archives des universités parmi les répondants) se renforce encore depuis 2014. La structuration d’un réseau des utilisat…
Les archives ouvertes : état des lieux en 2017
2018
International audience; Les archives ouvertes s’inscrivent de plus en plus solidement et durablement dans le paysage documentaire de l’enseignement supérieur. Si les organismes de recherche ont été précurseurs pour la création d’archives ouvertes, les grandes écoles, mais surtout les universités ont désormais massivement rejoint le mouvement. Signe de cette progression notable, 82 % des répondants disposent en 2017 d’une archive en production ou en cours de mise en œuvre, contre 62 % en 2014. L’adoption majoritaire de la plate-forme HAL (qui représente 79 % des archives en production et 84 % des archives des universités parmi les répondants) se renforce encore depuis 2014. La structuration …
Stimulation of sewage sludge treatment by carbon sources and bioaugmentation with a sludge-derived microbial consortium
2021
Abstract Recently, sewage sludge (SS) disposal has become one of the greatest global challenges. In this study, we aimed to evaluate the effect of faba bean straw (Straw-B), wheat straw (Straw-W), and wood-chip pellets (WCP) amended to SS, as well as bioaugmentation (BA), on the physicochemical characteristics and structure of the microbial community of the treated SS. Sixteen days of incubation of SS-containing mixtures revealed the highest efficiency of Straw-W(BA) in terms of SS stabilisation, i.e., the highest and most stable respiration intensity, the lowest ammonia emission, and the highest stimulation effect on the cress seedling growth. Shotgun sequencing data analysis showed that P…