Search results for "CONTINUA"
showing 10 items of 362 documents
A Retrospective Analysis about Frequency of Monitoring in Italian Chronic Myeloid Leukemia Patients after Discontinuation.
2020
Successful discontinuation of tyrosine kinase inhibitors has been achieved in patients with chronic-phase chronic myeloid leukemia (CML). Careful molecular monitoring after discontinuation warrants safe and prompt resumption of therapy. We retrospectively evaluated how molecular monitoring has been conducted in Italy in a cohort of patients who discontinued tyrosine kinase inhibitor (TKI) treatment per clinical practice. The outcome of these patients has recently been reported&mdash
Effect of aerobic exercise on insulin resistance and central adiposity disappeared after the discontinuation of intervention in overweight women
2016
Purpose: This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance (HOMA-IR) are maintained after discontinuation of intervention in the overweight/obese (OWOB) women. Methods: The study subjects were from 2 independent studies with similar aerobic exercise (AE) intervention programs. In study I, 15 OWOB postmenopausal women with pre-diabetes (body mass index, BMI = 24–33 kg/m2 , aged 52–65 years) completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study II, 12 OWOB (BMI = 25–35 kg/m2 , aged 30–50 years) premenopausal women participated in a 6-week AE and were followed for 4 years after the interve…
Evaluation of the predictive value of the bleeding prediction score VTE‐BLEED for recurrent venous thromboembolism
2019
Abstract Introduction VTE‐BLEED is a validated score for identification of patients at increased risk of major bleeding during extended anticoagulation for venous thromboembolism (VTE). It is unknown whether VTE‐BLEED high‐risk patients also have an increased risk for recurrent VTE, which would limit the potential usefulness of the score. Methods This was a post hoc analysis of the randomized, double‐blind, placebo‐controlled PADIS‐PE trial that randomized patients with a first unprovoked pulmonary embolism (PE) initially treated during 6 months to receive an additional 18‐month of warfarin vs. placebo. The primary outcome of this analysis was recurrent VTE during 2‐year follow‐up after ant…
Early virologic response with pegylated interferons
2004
Abstract Recently, 12-week evaluation of viral response has been recommended as a means of reducing antiviral treatment morbidity and costs. The development of early stopping rules relies on an important assumption: rules must minimise discontinuation of treatment in patients who might ultimately respond after completion of the full course of therapy. Minimising loss of potential responders is the most important clinical goal in defining an early stopping rule because it provides the most sustained virological responders. This definition of the rule relies on maximising the negative predictive value. Conversely, rules that select patients based on optimising the positive predictive value pr…
Pensamiento crítico y su impacto en el desempeño del proyecto de mejora continua
2022
¿Cómo influye el pensamiento crítico (PC) en el desempeño del proyecto de mejora continua (MC), considerando mediación de las capacidades dinámicas (CDs) que subyacen en dicho proyecto? Guiados por tal interrogante general, la tesis cubre tres aspectos. El primero se centra en la conceptualización y operativización del PC en la organización, bajo un marco de MC, lo cual redunda en el diseño y validación psicométrica de un modelo de medida al respecto. El segundo presenta el mismo alcance que el primero, pero esta vez comprende el constructo CDs del proyecto de MC. El tercero se orienta al contraste empírico de la relación estructural entre PC, CDs y desempeño del proyecto, usando analítica/…
La calidad en la gestión de los Servicios Sociales Municipales: algunas experiencias de INTRESS
2011
Queremos presentar en este breve artículo dos experiencias de INTRESS en el desarrollo de buenas prácticas que puedan ayudar a la implantación de sistemas de gestión de calidad en las administraciones locales así como en organizaciones y entidades del Tercer Sector. Se expone pues, por un lado, la experiencia desarrollada en la Concejalía de Acción Social, Mujer y Familia del Ayuntamiento de Valdemoro (Madrid) a través de la formación de sus profesionales en la gestión por procesos y la mejora continua y por otro lado, la iniciativa 'Indicadores Sociales' desarrollada por la red de Consultoría Social, para el desarrollo de una Web de indicadores sociales que permita compartir resultados y b…
User behaviours after critical mobile application incidents : the relationship with situational context
2017
Users occasionally have critical incidents with information systems (IS). A critical IS incident is an IS product or service experience that a user considers to be unusually positive or negative. Critical IS incidents are highly influential in terms of users’ overall perceptions and customer relationships; thus, they are crucial for IS product and service providers. Therefore, it is important to study user behaviors after such incidents. Within IS, the relationships between the situational context and user behaviors after critical incidents have not been addressed at all. Prior studies on general mobile use as a related research area have recognized the influence of the situational context,…
Why Is Your Crowd Abandoning You? : Exploring Crowdsourcing Discontinuance through the Lens of Motivation Theory
2019
A typical crowdsourcing platform connects organisations in need for workforce to individuals willing to work for a compensation. Considering that a motivated crowd constitutes a vital resource of such platforms, nurturing it becomes a crucial managerial consideration. Yet, little is known of why individual workers abandon crowdsourcing platforms after long periods of usage. Therefore, we set out to explore how crowd-workers’ motivations change during a platform’s usage lifecycle, from initial usage, to continued use, to its eventual abandonment. To this end, we conducted an in-depth qualitative inquiry into a popular crowdsourcing platform in the software-testing domain. Leveraging self-det…
Global representation and multiscale expansion for the Dirichlet problem in a domain with a small hole close to the boundary
2019
For each pair (Formula presented.) of positive parameters, we define a perforated domain (Formula presented.) by making a small hole of size (Formula presented.) in an open regular subset (Formula presented.) of (Formula presented.) ((Formula presented.)). The hole is situated at distance (Formula presented.) from the outer boundary (Formula presented.) of the domain. Thus, when (Formula presented.) both the size of the hole and its distance from (Formula presented.) tend to zero, but the size shrinks faster than the distance. Next, we consider a Dirichlet problem for the Laplace equation in the perforated domain (Formula presented.) and we denote its solution by (Formula presented.) Our ai…
Conseguenze metaboliche dell'ipossia
2011
Riassunto La sopravvivenza in condizioni di ipossia dipende dall’attivazione di processi cellulari complessi, con risposte di adattamento (quali il potenziamento del trasporto di O2 attraverso l’aumento dell’eritropoiesi, l’attivazione dell’angiogenesi e l’aumento della glicolisi anaerobica) e l’inibizione di processi metabolici che richiedono alta disponibilità di O2. Ciò consente di mantenere l’omeostasi energetica anche in condizioni di ridotta disponibilità di O2. Nel modello fisiologico del soggiorno ad alta quota si verificano riduzione di peso e della capacità di lavoro associata a riduzione della massa muscolare, che però sono reversibili al ripristino di condizioni di normossia. Le…