Search results for "CPVT"
showing 2 items of 2 documents
Trigeneration and Polygeneration Configurations for Desalination and Other Beneficial Processes
2018
Abstract The integration of renewable energy sources (geothermal, biomass, and solar) and desalination systems into novel polygeneration plants is investigated. Two main arrangements are considered: geothermal (GP) and biomass (BP) polygeneration. Both systems include concentrating photovoltaic/thermal solar collectors, a multieffect distillation system for seawater desalination, a single-effect LiBr-H2O absorption chiller, storage tanks, heat exchangers, balance-of-plant devices; a biomass auxiliary heater and geothermal wells are also included, in BP and GP, respectively. The systems can provide electricity and hot water, used for space heating, cooling, domestic hot water production, and…
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
2021
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …