Search results for "CREM"

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.

2019

Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…

2018

Background Attempts to establish a biomarker reflecting individual player load in intermittent sports such as football have failed so far. Increases in circulating DNA (cfDNA) have been demonstrated in various endurance sports settings. While it has been proposed that cfDNA could be a suitable marker for player load in intermittent sports, the effects on cfDNA of repeated sprinting as an essential feature in intermittent sports are unknown. For the first time, we assessed both alterations of cfDNA due to repeated maximal sprints and due to a professional football game. Methods Nine participants were subjected to a standardised sprint training session with cross-over design of five maximal s…

Evaluating a hierarchical approach to landscape-level harvest scheduling

2018

Forest planning at the landscape level has the potential to become a large intractable problem. In Finland, Metsähallitus (the state enterprise that manages federally owned land) creates strategic plans to determine the appropriate harvest level. While these plans are feasible, they are not implementable in practice as the harvests are scattered temporally and spatially. Requiring that harvests be organized both temporally and spatially for practical implementation can result in an intractable problem. Through a hierarchical approach, the problem can be organized into steps in which the intractable problem is broken down into smaller easily solvable parts. As an approximation technique, th…

EXTERNAL RECIRCULATION IN PRS TYPE TURBINE: EXPERIMENTAL AND NUMERICAL RESULTS.

2022

Cavitation is a relevant phenomenon for structural safety and noise level in hydraulic turbines, occurring when water pressure falls below the vapor value at a given temperature. In this case bubbles of vapor grow inside the liquid and move along with it. When the pressure returns above the vapor value the bubble collapses, and the pressure can locally achieve very high values, up to 7000 bars (Kumar & Saini, 2010). Moreover, if the bubble was confined also by the solid wall of a blade, the solid particles suspended in the fluid can be transported by the fluid ones and hit the solid wall at very high velocity, generating erosion. Cavitation is also the source of high frequency noise, ve…

Futuro profesional de los menores y ejercicio de la patria potestad

2021

The personal decision about the professional future of the minor, constitutes an aspect of the development of his free personality, and, like every decision that affects him, it must be adopted considering the principle of the best interests of the child. The parents, in the exercise of parental authority, have the legal representation of their minor children, except for the acts related to the personality rights, which can be carried out by the minor child himself if he is mature enough. When personality rights and economic rights converge, it is necessary to determine the role the parents play, which in the end will always have to be the protection and respect for their children?s rights.

La ?scelta? della cremazione in stato di pandemia.

2020

Lo scritto analizza la questione della cremazione dei defunti in rapporto ad una fase emergenziale come quella causata dalla diffusione pandemica del virus COVID-19. Si delineano le norme applicabili sul territorio italiano per effetto degli interventi legislativi d?urgenza, considerando anche gli interessi personalistici in rilievo nel caso concreto e la tutela che l?ordinamento giuridico nazionale riserva ai medesimi.

Acremines A-F, novel secondary metabolites produced by an endophytic strain of Acremonium sp., isolated in grape leaves infected by Plasmopara vitico…

2005

Six novel metabolites, acremines A–F have been isolated from agar cultures of a strain of Acremonium sp. Their structures and stereochemistry were elucidated using a combination of 13C and 1H homo and heteronuclear 2D NMR experiments and X-ray analysis. Acremines A–D inhibited the germination of sporangia of Plasmopara viticola.

Exercise Effects on Erythrocyte Deformability in Exercise-induced Arterial Hypoxemia

2014

Exercise-induced arterial hypoxemia (EIAH) is often found in endurance-trained subjects at high exercise intensity. The role of erythrocyte deformability (ED) in EIAH has been scarcely explored. We aimed to explore the role of erythrocyte properties and lactate accumulation in the response of ED in EIAH. ED was determined in 10 sedentary and in 16 trained subjects, both before and after a maximal incremental test, and after recovery, along with mean corpuscular volume (MCV) and red blood cell lactate concentrations. EIAH was found in 6 trained subjects (∆SaO2=-8.25±4.03%). Sedentary and non-EIAH trained subjects showed reduced ED after exercise, while no effect on ED was found in EIAH train…

Executive and arousal vigilance decrement in the context of the attentional networks: The ANTI-Vea task

2018

Vigilance is generally understood as the ability to detect infrequent critical events through long time periods. In tasks like the Sustained Attention to Response Task (SART), participants tend to detect fewer events across time, a phenomenon known as vigilance decrement. However, vigilance might also involve sustaining a tonic arousal level. In the Psychomotor Vigilance Test (PVT), the vigilance decrement corresponds to an increment across time in both mean and variability of reaction time. New Method: The present study aimed to develop a single task Attentional Networks Test for Interactions and Vigilance executive and arousal components (ANTI-Vea) to simultaneously assess both components…

Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise

2014

To investigate the kinetics of cell-free DNA (cfDNA) due to exercise, we established a direct real-time PCR for the quantification of cfDNA from unpurified capillary plasma by amplification of a 90- and a 222-bp multilocus L1PA2 sequence. Twenty-six male athletes performed an incremental treadmill test. For cfDNA measurement, capillary samples were collected serially from the fingertip preexercise, during, and several times postexercise. Venous blood was drawn before and immediately after exercise to compare capillary and venous cfDNA values. To elucidate the strongest association of cfDNA accumulations with either cardiorespiratory or metabolic function during exercise, capillary cfDNA val…