Search results for "CTL"
showing 10 items of 521 documents
Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance
2012
Background Allergic contact dermatitis is one of the most common occupational diseases. A main protective mechanism in those who do not develop allergic contact dermatitis is tolerance induction by repeated exposure to low doses of contact allergen, which is termed low zone tolerance (LZT). The mechanisms that determine the tolerance induction in subjects with LZT are still elusive. Objective We performed analysis of the role of CD4 + CD25 + forkhead box protein 3 (FOXP3)–positive regulatory T (Treg) cells and dendritic cells (DCs) in mice with LZT. Methods Mechanisms of tolerance induction were analyzed in a murine model of LZT by using FOXP3 and IL-10 reporter mice, as well as mice that a…
Exogenous introduction of an immunodominant peptide from the non-structural IE1 protein of human cytomegalovirus into the MHC class I presentation pa…
2008
Exogenous introduction of particle-associated proteins of human cytomegalovirus (HCMV) into the major histocompatibility complex (MHC) class I presentation pathway by subviral dense bodies (DB) is an effective way to sensitize cells against CD8 T-cell (CTL) recognition and killing. Consequently, these particles have been proposed as a platform for vaccine development. We have developed a strategy to refine the antigenic composition of DB. For proof of principle, an HCMV recombinant (RV-VM3) was generated that encoded the immunodominant CTL determinant IE1TMY from the IE1 protein in fusion with the major constituent of DB, the tegument protein pp65. To generate RV-VM3, a bacterial artificial…
Rotavirus-Specific Cytotoxic T Lymphocytes Recognize Overlapping Epitopes in the Amino-Terminal Region of the VP7 Glycoprotein
1999
Abstract Rotavirus-specific cytotoxic T lymphocytes (CTL) play an important role in the resolution of rotavirus infection. The outer capsid glycoprotein, VP7, elicits a class I MHC-restricted CTL response. Vaccinia virus recombinants expressing the VP7 genes from simian rotavirus SA11 (serotype G3) and from the RF strain of bovine rotavirus (serotype G6) were used to analyze the CTL activity to this antigen in BALB/c (H-2 d ) and C57BL/6 (H-2 b ) mice neonatally infected with homologous and heterologous rotaviruses. A vaccinia virus recombinant expressing the first amino-terminal 88 amino acids of VP7 was constructed and used to search for cross-reactive CTL against this region of the prote…
"Table 3" of "Comprehensive measurements of $t$-channel single top-quark production cross sections at $\sqrt{s} = 7$ TeV with the ATLAS detector"
2014
The cross sections for top-quark and top-antiquark production in the t-channel, together with the cross-section ratio.
Poisson-Nijenhuis structures and the Vinogradov bracket
1994
We express the compatibility conditions that a Poisson bivector and a Nijenhuis tensor must fulfil in order to be a Poisson-Nijenhuis structure by means of a graded Lie bracket. This bracket is a generalization of Schouten and Frolicher-Nijenhuis graded Lie brackets defined on multivector fields and on vector valued differential forms respectively.
Council Appointed Mayors in Spain: Effects on Local Democracy
2017
El presente artículo toma en consideración los efectos que el sistema de elección del Alcalde tiene sobre la democracia local, basándose en la consideración cinco aspectos: el sistema electoral y su influencia en la composición política de las administraciones locales; la estructura de la administración local y la distribución de funciones entre los alcaldes y el pleno municipal; el papel de los partidos políticos; los mecanismos de control del ejecutivo local y la participación ciudadana. El estudio subraya especialmente la incidencia que el sistema de elección del alcalde por los concejales tiene en relación con los principios de responsabilidad, legitimidad, transparencia y eficiencia de…
The Kp Hierarchy
1989
As an application of the theory of infinite-dimensional Grassmannians and the representation theory of gl1 we shall study in this chapter certain nonlinear “exactly solvable” systems of differential equations. Exactly solvable means here that the nonlinear system can be transformed to an (infinite-dimensional) linear problem. A prototype of the equations is the Korteweg-de Vries equation $$\frac{{\partial u}}{{\partial t}} = \frac{3}{3}u\frac{{\partial u}}{{\partial x}} + \frac{1}{4}\frac{{{\partial ^3}u}}{{\partial {x^3}}}$$ . It turns out that it is more natural to consider an infinite system of equations like that above, for obtaining explicit solutions. The set of equations is called th…
Generation of travelling sine-Gordon breathers in noisy long Josephson junctions
2022
The generation of travelling sine-Gordon breathers is achieved through the nonlinear supratransmission effect in a magnetically driven long Josephson junction, in the presence of losses, a current bias, and a thermal noise source. We demonstrate how to exclusively induce breather modes by means of controlled magnetic pulses. A nonmonotonic behavior of the breather-only generation probability is observed as a function of the noise intensity. An experimental protocol providing evidence of the Josephson breather's existence is proposed.
Note di Abū Naṣr al-Fārābī sulla verità e falsità dell’astrologia
2020
Il presente contributo propone l’introduzione, la traduzione italiana e il commento delle Note sulla verità e falsità dell’astrologia (Nukat fī mā yaṣiḥḥu wa-mā lā yaṣiḥḥu min aḥkām al-nuǧūm) di Abū Naṣr al-Fārābī (m. 950). Tale scritto non è stato trasmesso direttamente dal suo autore né ci è giunto nella sua redazione definitiva, bensì in forma di appunti ricopiati da un grammatico di nome Abū Isḥāq al-Baġdādī. In trenta brevi capitoli al-Fārābī spiega ciò che è accessibile e ciò che è inaccessibile alle predizioni astrologiche e quali aspetti di tale scienza sia opportuno accogliere o respingere.
Shock formation in the dispersionless Kadomtsev-Petviashvili equation
2016
The dispersionless Kadomtsev-Petviashvili (dKP) equation $(u_t+uu_x)_x=u_{yy}$ is one of the simplest nonlinear wave equations describing two-dimensional shocks. To solve the dKP equation we use a coordinate transformation inspired by the method of characteristics for the one-dimensional Hopf equation $u_t+uu_x=0$. We show numerically that the solutions to the transformed equation do not develop shocks. This permits us to extend the dKP solution as the graph of a multivalued function beyond the critical time when the gradients blow up. This overturned solution is multivalued in a lip shape region in the $(x,y)$ plane, where the solution of the dKP equation exists in a weak sense only, and a…