Search results for "CTL"
showing 10 items of 521 documents
Numerical study of the Kadomtsev–Petviashvili equation and dispersive shock waves
2018
A detailed numerical study of the long time behaviour of dispersive shock waves in solutions to the Kadomtsev-Petviashvili (KP) I equation is presented. It is shown that modulated lump solutions emerge from the dispersive shock waves. For the description of dispersive shock waves, Whitham modulation equations for KP are obtained. It is shown that the modulation equations near the soliton line are hyperbolic for the KPII equation while they are elliptic for the KPI equation leading to a focusing effect and the formation of lumps. Such a behaviour is similar to the appearance of breathers for the focusing nonlinear Schrodinger equation in the semiclassical limit.
SHARP: Environment and Person Independent Activity Recognition with Commodity IEEE 802.11 Access Points
2022
In this article we present SHARP, an original approach for obtaining human activity recognition (HAR) through the use of commercial IEEE 802.11 (Wi-Fi) devices. SHARP grants the possibility to discern the activities of different persons, across different time-spans and environments. To achieve this, we devise a new technique to clean and process the channel frequency response (CFR) phase of the Wi-Fi channel, obtaining an estimate of the Doppler shift at a radio monitor device. The Doppler shift reveals the presence of moving scatterers in the environment, while not being affected by (environment-specific) static objects. SHARP is trained on data collected as a person performs seven differe…
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
2000
The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …
Side effect management during immune checkpoint blockade using CTLA-4 and PD-1 antibodies for metastatic melanoma – an update
2020
CTLA-4 and PD-1 play a key role in tumor-induced downregulation of lymphocytic immune responses. Immune checkpoint inhibitors have been shown to alter the immune response to various cancer types. Anti-CTLA-4 and anti-PD-1 antibodies affect the interaction between tumor, antigen-presenting cells and T lymphocytes. Clinical studies of the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibodies nivolumab and pembrolizumab have provided evidence of their positive effects on overall survival in melanoma patients. Combined treatment using ipilimumab and nivolumab has been shown to achieve five-year survival rates of 52 %. Such enhancement of the immune response is inevitably associated with …
UV Exposure Boosts Transcutaneous Immunization and Improves Tumor Immunity: Cytotoxic T-Cell Priming through the Skin
2010
Immunologic approaches to combat cancer aim at the induction of tumor-reactive immune responses to achieve long-term protection. In this context, we recently developed a transcutaneous immunization (TCI) method using the Toll-like receptor (TLR) 7 agonist imiquimod and a peptide epitope. Application onto intact skin induces potent cytotoxic T lymphocyte (CTL) responses and protection against transplanted tumors. The purpose of this study was to explore the effects of UV irradiation on imiquimod-based TCI. Here we show that skin exposure to low-dose UV light before TCI with imiquimod strongly boosts specific CTL responses leading to memory formation and enhanced tumor protection. Toward the …
Numerical study of soliton stability, resolution and interactions in the 3D Zakharov–Kuznetsov equation
2021
International audience; We present a detailed numerical study of solutions to the Zakharov-Kuznetsov equation in three spatial dimensions. The equation is a three-dimensional generalization of the Korteweg-de Vries equation, though, not completely integrable. This equation is L-2-subcritical, and thus, solutions exist globally, for example, in the H-1 energy space.We first study stability of solitons with various perturbations in sizes and symmetry, and show asymptotic stability and formation of radiation, confirming the asymptotic stability result in Farah et al. (0000) for a larger class of initial data. We then investigate the solution behavior for different localizations and rates of de…
Numerical study of blow-up and stability of line solitons for the Novikov-Veselov equation
2017
International audience; We study numerically the evolution of perturbed Korteweg-de Vries solitons and of well localized initial data by the Novikov-Veselov (NV) equation at different levels of the 'energy' parameter E. We show that as |E| -> infinity, NV behaves, as expected, similarly to its formal limit, the Kadomtsev-Petviashvili equation. However at intermediate regimes, i.e. when |E| is not very large, more varied scenarios are possible, in particular, blow-ups are observed. The mechanism of the blow-up is studied.
Covariant Operator Formalism for Quantized Superfields
1988
The Takahashi-Umezawa method of deriving the free covariant quantization relations from the linear equations of motion is extended to superfields. The Cauchy problem for free superfields is solved, and an expression for the time independent scalar product is given. For the case of interacting fields, we give the general Kallen-Lehmann spectral representation for the two-point superfield Green functions and, after the introduction of the asymptotic condition for superfields, we give the superfield extension of the Yang-Feldman equation. The case of the D = 2 real scalar superfield and the case of the D = 4 chiral superfield are discussed in detail.
Wronskian and Casorati determinant representations for Darboux–Pöschl–Teller potentials and their difference extensions
2009
We consider some special reductions of generic Darboux?Crum dressing formulae and of their difference versions. As a matter of fact, we obtain some new formulae for Darboux?P?schl?Teller (DPT) potentials by means of Wronskian determinants. For their difference deformations (called DDPT-I and DDPT-II potentials) and the related eigenfunctions, we obtain new formulae described by the ratios of Casorati determinants given by the functional difference generalization of the Darboux?Crum dressing formula.
Other 2N− 2 parameters solutions of the NLS equation and 2N+ 1 highest amplitude of the modulus of theNth order AP breather
2015
In this paper, we construct new deformations of the Akhmediev-Peregrine (AP) breather of order N (or APN breather) with real parameters. Other families of quasirational solutions of the nonlinear Schrodinger (NLS) equation are obtained. We evaluate the highest amplitude of the modulus of the AP breather of order N; we give the proof that the highest amplitude of the APN breather is equal to . We get new formulas for the solutions of the NLS equation, which are different from these already given in previous works. New solutions for the order 8 and their deformations according to the parameters are explicitly given. We simultaneously get triangular configurations and isolated rings. Moreover,…