Search results for "CUL4A"

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CUL4A, ERCC5, and ERCC1 as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (…

2020

A translational study was designed to analyze the expression of nucleotide excision repair (NER) and homologous recombination (HR) genes as potential predictive biomarkers for trabectedin in soft-tissue sarcoma (STS). This study is part of a randomized phase II trial comparing trabectedin plus doxorubicin versus doxorubicin in advanced STS. Gene expression levels were evaluated by qRT-PCR, while CUL4A protein levels were quantified by immunohistochemistry. Expression levels were correlated with patients&rsquo

0301 basic medicineOncologyCancer Researchmedicine.medical_specialtylcsh:RC254-282Articlepredictive biomarkers03 medical and health sciences0302 clinical medicinePredictive biomarkersInternal medicineGene expressionmedicineDoxorubicinTrabectedinbusiness.industrySoft tissue sarcomasoft-tissue sarcomalcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.disease030104 developmental biologyOncology030220 oncology & carcinogenesistrabectedinSoft-tissue sarcomaImmunohistochemistryCUL4ASarcomaERCC1CUL4AERCC1businessTrabectedinmedicine.drugCancers

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