Search results for "CX"

How domain-sensitive are existential constructions? Evidence from Swedish and Dutch weather reports

2020

International audience; [Introduction] Over the last two decades, linguists have shown considerable interest in the advantages of CxG-theories for various linguistic sub-disciplines. A particular question that has arisen within more “applied” frameworks, is whether or not constructions can have domain-specific manifestations regarding meaning and/or form (Fischer/Nikiforidou 2015; Bücker/Günther/Imo 2015; Gautier/Bach 2019). However, sufficient empirical analyses are currently missing, and this research question needs to be more systematically tested for constructions in various languages and different LSP-oriented domains. Beside the mere “applied” focus, such work can lead to interestin…

Analysis of connexin (Cx36 and Cx45) expression in the carotid body, adrenal medulla and enteric neurons of both mouse and rat

2009

Cx36 and Cx45 are considered the main connexins expressed in neuronal cells of central nervous system (Belluardo N. et al. Brain Res. 2000)), but at present no complete data are available on their expression in the neurons of crest-derived neuroendocrine organ, such as the adrenal medulla, the carotid body and the enteric nervous system. Therefore the present study was undertaken to evaluate using immunohistochemistry and western blotting procedures, both in rat and mouse, whether Cx36 and Cx45 were expressed in neuronal cells of the carotid body, adrenal medulla and myenteric plexus at ileum and colon level. In the carotid body of both mouse and rat only Cx45 was found expressed as diffuse…

Recovery of damaged skeletal muscle in mdx mice by low-intensity endurance exercise

2010

Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz

2012

Hepatic toxicity and metabolic disorders are major adverse effects elicited during the pharmacological treatment of the human immunodeficiency virus (HIV) infection. Efavirenz (EFV), the most widely used non-nucleoside reverse transcriptase inhibitor (NNRTI), has been associated with these events, with recent studies implicating it in stress responses involving mitochondrial dysfunction and oxidative stress in human hepatic cells. To expand these findings, we analyzed the influence of EFV on the expression profile of selected stress and toxicity genes in these cells. Significant up-regulation was observed with Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), which indicated m…

Mouse langerhans cells differentially express an activated T cell-attracting CC chemokine.

1999

Epidermal Langerhans cells represent an immature population of dendritic cells, not yet able to prime naive T cells. Following in vitro culture Langerhans cells mature into potent immunostimulatory cells. We constructed a representative cDNA library of in vitro matured murine Langerhans cells. Applying a differential screening procedure 112 differentially expressed cDNA clones were isolated. Thirty-six clones represented cDNA fragments of the same gene, identifying it to be the most actively expressed gene induced in maturing Langerhans cells. A full-length cDNA was sequenced completely. The open reading frame codes for a protein of 92 amino acids containing a leader peptide of 24 amino aci…

The formation of peak rings in large impact craters.

2016

The Chicxulub impact crater, known for its link to the demise of the dinosaurs, also provides an opportunity to study rocks from a large impact structure. Large impact craters have “peak rings” that define a complex crater morphology. Morgan et al. looked at rocks from a drilling expedition through the peak rings of the Chicxulub impact crater (see the Perspective by Barton). The drill cores have features consistent with a model that postulates that a single over-heightened central peak collapsed into the multiple-peak-ring structure. The validity of this model has implications for far-ranging subjects, from how giant impacts alter the climate on Earth to the morphology of crater-dominated …

A Life Cycle Model of XML Documents

2014

Electronic documents produced in business processes are valuable information resources for organizations. In many cases they have to be accessible long after the life of the business processes or information systems in connection with which they were created. To improve the management and preservation of documents, organizations are deploying Extensible Markup Language (XML) as a standardized format for documents. The goal of this paper is to increase understanding of XML document management and provide a framework to enable the analysis and description of the management of XML documents throughout their life. We followed the design science approach. We introduce a document life cycle model…

Two Methods for Schema Design for Intelligent XML Documents in Organizations

2007

XML markup language provides means for incorporating semantics, i.e. “meaning” of logical content parts residing within documents. Therefore it has become the lingua franca for Semantic Web, e-Business applications and for enterprise application integration. In order to realize novel, intelligent XML-based document applications in organizations, schemas defining the domain-oriented semantics are needed. So far, the potential of XML has not bee fully utilized in organizational documents, due to the lack of XML support in common and inexpensive office software. Due to the arrival of XML support on common software such as Microsoft Office 2007 and Open Office 2.0 organizations need knowledge a…

Estudio de marcadores de enfermedad mínima residual en neuroblastoma y de su posible aplicación clínica

2016

El neuroblastoma es el tumor sólido extracraneal más frecuente en la infancia y el cuarto en frecuencia en el conjunto global de neoplasias infantiles. Su incidencia en nuestro país, según el RNTI oscila entre 8-10 casos por millón de niños y año, por lo que su frecuencia supone alrededor de un 8-10% de todos los tumores en niños. Sin embargo, es el responsable de aproximadamente un 15% del total de muertes provocadas por cáncer pediátrico. La edad media del diagnóstico es de 22 meses, dos tercios de los casos se presentan antes de los 5 años de edad y en un 97% los pacientes tienen menos de 10 años. El tumor es más común en niños que en niñas, siendo el ratio niño/niña aproximadamente 1,3/…

Nanog Regulates Primordial Germ Cell Migration Through Cxcr4b

2010

Abstract Gonadal development in vertebrates depends on the early determination of primordial germ cells (PGCs) and their correct migration to the sites where the gonads develop. Several genes have been implicated in PGC specification and migration in vertebrates. Additionally, some of the genes associated with pluripotency, such as Oct4 and Nanog, are expressed in PGCs and gonads, suggesting a role for these genes in maintaining pluripotency of the germ lineage, which may be considered the only cell type that perpetually maintains stemness properties. Here, we report that medaka Nanog (Ol-Nanog) is expressed in the developing PGCs. Depletion of Ol-Nanog protein causes aberrant migration of …