Search results for "CYP39A1"

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<i>NR1H4</i> rs35724 G>C Variant Modulates Liver Damage in Nonalcoholic Fatty Liver Disease

2020

Background and Aims: Farnesoid X receptor (FXR) plays a key role in bile acid and lipid homeostasis. Experimental evidence suggests that it can modulate liver damage related to nonalcoholic fatty liver disease (NAFLD). We examined the impact of the NR1H4 rs35724 variant, encoding for FXR, on liver damage in a large cohort of patients at risk of steatohepatitis. Methods: We considered 2,660 consecutive individuals at risk of steatohepatitis with liver histology. The rs35724 G>C polymorphisms was genotyped by TaqMan assays. Gene expression was evaluated by RNASeq in a subset of patients (n=124). Results: The NR1H4 rs35724 variant was protective against severity of steatosis (OR 0.89, 95% C.I.…

0303 health sciencesmedicine.medical_specialtyBile acidCholesterolbusiness.industrymedicine.drug_class030302 biochemistry & molecular biologymedicine.diseaseGastroenterology3. Good health03 medical and health scienceschemistry.chemical_compoundchemistryFibrosisInternal medicineNonalcoholic fatty liver diseasemedicineCYP39A1Farnesoid X receptorSteatosisSteatohepatitisbusiness030304 developmental biologySSRN Electronic Journal
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