Search results for "CYP"

The impact of space development structure on the level of ecological footprint - Shift share analysis for European Union countries

2022

The impact of the space development structure on the level of the ecological footprint is an important element of the sustainable development policy, determining not only its directions, but also indicating the manner of respecting en- vironmental principles. The aim of the research is to assess the impact of the spatial development structure on the eco- logical footprint level. The considerations are based on the assumption that the spatial development structure is a determinant of the ecological footprint level. The study used the shift share analysis method. Selected European coun- tries were the subject of the research. The research period covered the years 2009–2019. The spatial differ…

Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme inductio…

2000

The use of primary hepatocytes is now well established for both studies of drug metabolism and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for fresh liver tissue. This is especially important for research with human hepatocytes because availability of human liver tissue is limited. In this review, we summarize our research on optimization and validation of cryopreservation techniques. The critical elements for successful cryopreservation of hepatocytes are (1) the freezing protocol, (2) the concentration of the cryoprotectant [10% dimethyl-sulfoxide (DMSO)], (3) slow addition and removal of DMSO, (4) carbogen equilibration during isolation of hepatocytes and…

Cypress pollen: An unexpected major sensitizing agent in different regions of Italy

2014

In this multicenter survey, we assessed the impact of sensitization to cypress in atopic patients in Italy and determined whether cypress pollen concentration changed over time.Allergists were required to collect the results of 100-200 consecutive skin prick tests (SPTs) performed during 2012. Seasonal symptoms were also recorded, as were airborne cypress pollen concentrations (data from the Italian Aerobiology Association) in 1998-2000 and 2010-2012.We examined 2258 atopic outpatients (56% females; age, 2-84 years) sensitized to at least 1 of the aeroallergens tested (Dermatophagoides species, grass, pellitory, olive, cypress, birch, Alternaria tenuis, and dog and cat dander). We found tha…

Food selection in Eucypris virens (Crustacea: Ostracoda) under experimental conditions

2007

Ostracods have long been studied by scientists because their fossil remnants provide a valuable tool for the reconstruction of past environmental changes, including climate change and anthropogenic eutrophication. Relatively little is known about the physiology, behaviour and reproductive ecology of recent forms. We argue that filling this gap in knowledge requires stable cultures that can be used in laboratory studies. Here we provide quantitative information on the food preference of the common non-marine ostracod Eucypris virens. Using an experimental device allowing a free choice of eight food items, including both auto- and heterotrophic organisms, observations were carried out on grou…

[Pharmacogenomics of antiretrovirals].

2008

HIV infection is a serious but treatable disease, yet current treatment is limited by development of resistance and high rates of adverse drug reactions. Antiretroviral therapy is especially suitable for pharmacogenomic investigation as both drug exposure and treatment response can be reliably measured. Increasing knowledge about genes implicated in pharmacokinetics, mode of action, efficacy, and toxicity of drugs has already provided relevant results for clinical practice, for example: The strong association of the abacavir hypersensitivity reaction with HLA-B*5701 permits testing patients for the allele, and if present avoiding the drug and therefore preventing the reaction. Persons with …

Pharmacokinetic interaction between efavirenz and ketoconazole in rats

2009

It is well known that efavirenz and ketoconazole act as an inducer and inhibitor of CYP3A4, respectively. As a result of these actions, co-administration of these drugs may result in changes in the pharmacoki- netic parameters of one or both of them. 2. Duodenum-cannulated rats have been used to compare the effect of intraduodenal (KC i.d. ) and intrave- nous administration of ketoconazole (KC i.v. ) on the pharmacokinetics of efavirenz after intraduodenal administration, as well as the potential effect of efavirenz as a CYP450 inducer on ketoconazole phar - macokinetic profile. 3. While KC i.v. did not show any significant effect on efavirenz pharmacokinetic profile, KC i.d. increased sig-…

Notula 128, Cyperus eragrostis. – P. 189 in: PERUZZI L., NEPI C., PECCENINI S. (EDS): Notulae alla flora esotica d’Italia 6 (115-136).

2012

Generic revision of Cypricercinae McKenzie, 1971 (Crustacea, Ostracoda), with the description of three new genera and one new species and a phylogene…

2009

The Cypricercinae are one of the most speciose subfamilies of non-marine ostracods, with more than 170 described species, mostly from the tropics. Although the identity of the subfamily as such is clear, because of the presence of unifying characters such as the Triebel’s loop in the attachment of the caudal ramus, the supra-specific taxonomy of this group has long been confused because of lack of good generic and tribal characters. Here, the generic characters of the Cypricercinae are revised. Eleven genera are retained in this subfamily, including three new genera: Bradleytriebella n. gen., Nealecypris n. gen. and Pseudostrandesia n. gen. Tanycypris siamensis n. sp. is described from Thai…

Les enjeux cognitifs et linguistiques du sujet parlant plurilingue en néoténie linguistique : le cas du locuteur chypriote-grec

2019

It is not realistic to claim that a speaker can use a language perfectly or that he /she has an excellent knowledge of whichever language, like many speakers like to claim when asked. It is true that a speaker may have some excellent linguistic skills, however cognitively speaking, this doesn’t say much. The cognitive relations that we maintain with the world’s languages are far beyond the linguistic dimension, excessively found in textbooks. Speaking a language means being able to exist in that language, in the sense that our being is there registered. We are led by our linguistic intuition to express ourselves and we do it spontaneously with respect to each language’s boundaries. However,…

The onset of the Messinian salinity crisis: Insights from Cyprus sections.

2009

International audience