Search results for "CYP"

Note nomenclaturali, tassonomiche e corologiche su Cyperus papyrus L. (Cyperaceae)

2011

A research on the action of testosterone propionate and of ciproterone acetate on the mouse-killing behaviour of the adult rat.

1979

AbstractData demonstrate exactly that testosterone favour above all the killing behaviour of castrate males at birth in comparison with control males while ciproterone acetate turns out to be more effective in diminishing the killing behaviour of males having integral testicle and of androgenized females at birth in comparison with castrated males.The results point out that the killing behaviour of rats is affected by the presence of testosterone in the first days of life, and in the grown-up animal.

Host specificity of Argulus coregoni (Crustacea: Branchiura) increases at maturation.

2007

SUMMARYWe tested the hypothesis that host specificity in ectoparasites does not depend exclusively on the features of the host but also on surrounding habitats, using 2 fish ectoparasites, Argulus coregoni and A. foliaceus (Crustacea: Branchiura), occurring sympatrically in Finnish lakes. Although these parasites are considered to be of low specificity, we found that the larger of the 2 species, A. coregoni developed a pronounced preference for salmonid hosts at the beginning of maturation (defined by the presence of copulating specimens). Argulus foliaceus infects a much wider range of fish hosts. We showed that specialization of A. coregoni on salmonids does not necessarily result from in…

Research focusing on plant performance in constructed wetlands and agronomic application of treated wastewater – A set of experimental studies in Sic…

2019

Constructed wetlands are sustainable technologies for the treatment of wastewater. These biological systems have been widely studied throughout the world for more than 30 years; however, most studies have focused on the effects of design and engineering on pollutant removal from wastewater. Undoubtedly, agro-technical aspects have been given too little consideration by research. This paper reports the main results of a set of experiments carried out on two pilot horizontal subsurface flow systems in Sicily (Italy). Festuca, Lolium and Pennisetum spp. in combination and three emergent macrophytes-Arundo donax L., Cyperus alternifolius L. and Typha latifolia L.-alone, were assessed. The aim o…

Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes

2020

International audience; The aryl hydrocarbon receptor (AhR) is a chemical sensor upregulating the transcription of responsive genes associated with endocrine homeostasis, oxidative balance and diverse metabolic, immunological and inflammatory processes, which have raised the pharmacological interest on its modulation. Herein, a novel set of 32 unsymmetrical triarylmethane (TAM) class of structures has been synthesized, characterized and their AhR transcriptional activity evaluated using a cell-based assay. Eight of the assayed TAM compounds (14, 15, 18, 19, 21, 22, 25, 28) exhibited AhR agonism but none of them showed antagonist effects. TAMs bearing benzotrifluoride, naphthol or heteroarom…

Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein α and Hepatocyte Nuclear Factor-3γ

2003

Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more than 50% of currently used therapeutic drugs, yet the mechanisms that control CYP3A4 basal expression in liver are poorly understood. Several putative binding sites for CCAAT/enhancer-binding protein (C/EBP) and hepatic nuclear factor 3 (HNF-3) were found by computer analysis in CYP3A4 promoter. The use of reporter gene assays, electrophoretic mobility shift assays, and site-directed mutagenesis revealed that one proximal and two distal C/EBP alpha binding sites are essential sites for the trans-activation of CYP3A4 promoter. No trans-activation was found in similar reporter gene experiments with a HNF-3 gamma expression vec…

The recipient CYP2D6 allele 4-associated poor metabolizer status correlates with an early fibrosis development after liver transplantation

2011

Summary CYP2D6 is part of the cytochrome P450 system, which catalyzes biotransformation of endogenous substrates and xenobiotics. Approximately 10% of the Caucasian population has two null alleles, resulting in a poor metabolizer (PM) status. Mostly, allele four (CYP2D6*4) is responsible for the PM status, which is suspected to be associated with an accelerated fibrosis progression (FP). The aim of the present study was to analyze the role of the CYP2D6*4 genotype for FP after liver transplantation (LT). Genotypes were determined in liver biopsies (donor) and peripheral blood (recipient) by fluorescence resonance energy transfer. Data were correlated with clinical variables and risk factors…

Effects of plant species in a horizontal subsurface flow constructedwetland – phytoremediation of treated urban wastewater withCyperus alternifolius …

2013

Abstract Plant species carry out a series of important biological, chemical and physical processes within a constructed wetland wastewater treatment system and make a significant contribution to wastewater purification. This paper compares two emergent macrophytes – Cyperus alternifolius L. and Typha latifolia L. – planted separately in a pilot horizontal subsurface flow system for the phytoremediation of treated urban wastewater in the West of Sicily (Italy). The total surface area of the three units within the pilot system was 99 m 2 . Six subunits were planted with two species and three subunits were left unplanted as the control. The main aim of the study was to demonstrate that, under …

Bezpilota gaisa kuģu attēlu apstrādes iespējas medūzu Aurelia aurita kvantificēšanā Rīgas līcī

2022

Globāli ir novērota medūzu biomasas palielināšanās, kas saistīta ar klimata pārmaiņām, eitrofikāciju un pārzveju. Medūzu populāciju pieaugums negatīvi ietekmē un liecina par nelabvēlīgu jūras ekoloģisko stāvokli, kā arī traucē akvakultūras, tūrisma, būvniecības, enerģētikas un citu industriju funkcionēšanai. Tomēr Baltijas jūras reģionā vienota medūzu kvantificēšanas metodoloģija joprojām nepastāv. Šī bakalaura darba mērķis ir izvērtēt bezpilota gaisa kuģu attēlu apstrādes iespējas ausainās aurēlijas Aurelia aurita kvantificēšanā Rīgas līcī. Darbā veikta zinātniskās literatūras analīze, veikti medūzu novērojumi ar bezpilota gaisa kuģi gar Rīgas līča dienvidaustrumu piekrasti, analizēti uzņe…

Tuning host specificity during the ontogeny of a fish ectoparasite: behavioural responses to host-induced cues

2003

The choice between two alternative hosts, brown trout (Salmo trutta) and roach (Rutilus rutilus), and the response to visual and olfactory cues were studied in the ontogeny of Argulus coregoni. The initial preference of the smallest parasites for brighter roach changed at the age of 2 weeks, at the size of about 2 mm, for trout, a typical salmonid host. Younger argulids were attracted by a non-specific visual stimulus (white disc over dark background), and they did not respond to olfactory stimulation (fish-conditioned water). Later, the response to visual stimuli was modulated by trout-conditioned water, but not by that conditioned by roach. The primary role of vision, particularly in earl…