Search results for "Cain"

SATURABLE PRESYSTEMIC ELIMINATION OF THE ANTIARRHYTHMIC DRUG LORCAINIDE

1978

Cross-reinstatement between 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using conditioned place preference.

2019

Abstract 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) considered to be a cocaine-like psychostimulant. The substitution of an established illicit drug as cocaine with an NPS is a pattern of use reported among drug users. The aim of this study was to investigate the relationship between cocaine and MDPV in the reinstatement of the conditioned place preference (CPP) paradigm, in order to establish whether there is cross-reinstatement between the two psychostimulants. Four experimental groups of male OF1 mice were subjected to the CPP paradigm: MDPV-MDPV, Cocaine-Cocaine, Cocaine-MDPV, and MDPV-Cocaine. The first drug refers to the substance with which the animal…

In VitroRelease of Local Anaesthetic and Anti-Inflammatory Drugs from Crosslinked Collagen Based Device

2012

The drug delivery systems that are the object of this article take the form of a hydrophilic matrix (collagen or crosslinked collagen) containing a drug. These devices can be used as The model active agents, were chosen from the range of local anaesthetics (lidocaine hydrochloride), anti-inflammatory (diclofenac sodium salt) and antioxydant (caffeic acid). Whatever the drug affinity for water, in the first time of the experiments, the release appears to be systematically delayed when the matrix is crosslinked. For lidocaine hydrochloride based systems, as the amount of drug increases in the matrix, the high gap concentration between the matrix and the buffer solution promote the diffusion a…

Perspiration versus saliva--basic aspects concerning their use in roadside drug testing.

1999

Various aspects concerning the practical application and forensic interpretation of data obtained by saliva drug testing and drug monitoring from the skin surface are discussed. Basic information on the composition of saliva and skin secretions and their particular transport mechanisms, as far as known, are given. For drugs of abuse secretion into saliva is suggested to be by passive diffusion and to depend on lipid solubility, pKa, plasma protein binding and on the pH of saliva. Drug molecules from blood are considered to reach the skin surface by various routes such as by sweat and sebum as well as by inter- and/or transcellular diffusion. The role of the stratum corneum as a temporary dr…

Ecole démocratique, école républicaine : Prévention des conséquences civiques de l'intégrisme religieux et notation des élèves

2015

National audience; Ce texte prend appui sur la notion de Modèle Politique d'Education (en opposant le modèle démocratique de l'Amérique du Nord (Etats-Unis, Québec) au modèle républicain (France)), modèles dont il teste la pertinence à partir du questionnaire élèves de PISA 2012, pour traiter de deux questions d'actualité : comment réduire la compréhension dont bénéficient les djihadistes auprès de certains élèves, comment mettre l'évaluation des élèves au service de leurs apprentissages? Sur le premier point, il explique pourquoi le modèle démocratique est plus adapté et indique quelles caractéristiques de l'école démocratiques peuvent être mobilisées. Sur le second, il plaide que la quest…

Plus de démocratie dans l'école de la République

2015

National audience; Ce texte défend l'idée que ce qui permettrait de réduire le nombre de jeunes scolarisés en France qui manifestent de la compréhension, voire de l'admiration, pour les djihadistes est une évolution vers une école plus démocratique (donner envie de vivre dans une société libre, donner aux élèves la possibilité et le gout d'échanger avec les autres, insister sur le caractère exigeant mais aussi précaire des vérités scientifiques...) plutôt qu'une réactivation des schèmes obsolètes de l'école républicaine (jouer l'autorité de la raison contre celle de la religion, celle des enseignants contre celle des parents).

Social Housing Conditions Modulate the Long-Lasting Increase in Cocaine Reward Induced by Intermittent Social Defeat

2019

Social defeat is considered the most representative animal model for studying the consequences of social stress. Intermittent social defeat (ISD) has proved to enhance the response to cocaine hedonic properties. In the present research, we evaluated if different social housing conditions, as housing with a familiar conspecific or with a female, exert a protective effect modulating the negative consequences of ISD as the increased sensitivity to cocaine and the induction of anxiety-like behavior. To achieve this objective, non-stressed or ISD OF1 male mice were divided into five different experimental groups according to their social environment: standard housing (four adult males per cage);…

Intermittent Horner's syndrome on alternate sides: a hint for locating spinal lesions.

1980

A patient with a cervical intramedullary ependymoma is described who exhibited a Horner's syndrome on alternate sides. Pharmacological study demonstrated damage to the pre-ganglionic sympathetic neurons. Disregarding cases with the Shy-Drager syndrome, three comparable case reports have been found in the literature where the fluctuating expression of Horner's syndrome, alternating from one side to the other, was attributable to a lesion of the cervical spinal cord. In contrast to the present patient, the pharmacological responses of these patients indicated a lesion of the central sympathetic pathway.

Cardiovascular effect of dental anesthesia with articaine (40 mg with epinefrine 0,5 mg % and 40 mg with epinefrine 1 mg%) versus mepivacaine (30 mg …

2011

Objectives: The aim of the present study is to compare cardiovascular safety profiles of two dental anesthetics: articaine versus two standard mepivacaine solutions used during etiological periodontal treatment in cardiovascular patients. Study Design: Using a cross-over study design, ten cardiovascular patients were randomly assigned to dental treatment with 1.8mL of a local anesthetic injected on each quadrant of the mouth: Articaine (40mg with Epinephrine 0.5mg % and 40mg with Epinephrine 1mg %) or Mepivacaine (30mg and 20mg with Epinephrine 1mg %). A computer programme enabled continuous longitudinal data collection: O2 saturation, blood pressure (BP) and heart rate (HR). Results: No se…

Esclaves et franciscains. L’accès dans les ordres mendiants et l’affranchissement (Sicile, XVI-XVIIe siècle)

2018

L’affranchissement individuel au sein d’une société à esclaves ou esclavagiste informe sur des situations singulières ou exceptionnelles. Dans une perspective comparatiste, cet ouvrage examine les parcours originaux de ces affranchis entre le xive siècle et le début du xixe siècle, et dans un vaste espace méditerranéen et atlantique – entre la péninsule Ibérique médiévale, les Antilles et l’Europe moderne. Il retrace la vie et le destin de ces individus, majoritairement d’origine africaine, et pose des questions importantes. Quelles ont pu être les stratégies et l’agentivité développées par ces femmes et ces hommes pour gagner leur liberté ? Quel était ce rapport paradox…