Search results for "Cance"
showing 10 items of 12092 documents
Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis
2022
Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…
Radiation protection of patients undergoing high-dose-rate brachytherapy: peripheral dose estimation, review of radiation risks and implant shielding…
2015
La braquiterapia (BT) es una modalidad de tratamiento de radioterapia en la que se coloca una fuente radiactiva encapsulada cerca, en contacto o en el interior del volumen a tratar. La desintegración de esta fuente produce la emisión de energía, lo que puede dar lugar a la muerte celular. Una dosis absorbida muy elevada (la dosis absorbida se define como la energía absorbida por unidad de masa) se deposita en un corto período de tiempo y en un pequeño número de fracciones. Para poder realizar un tratamiento de BT se requiere que el volumen de tratamiento sea accesible y bien delimitado en tamaño y forma. La BT se utiliza comúnmente como una modalidad de tratamiento eficaz para el cáncer de …
Peroxisome Proliferator-Activated Receptors and Atherosclerosis
2011
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, …
Is HLA type a possible cancer risk modifier in Lynch syndrome?
2022
Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…
The Value of Liquid Biopsies for Guiding Therapy Decisions in Non-small Cell Lung Cancer
2019
Modulation of Efficient Diiodo-BODIPY in vitro Phototoxicity to Cancer Cells by Carbon Nano-Onions
2020
Photodynamic therapy (PDT) is currently one of the most promising approaches for targeted cancer treatment. It is based on responses of vital physiological signals, namely reactive oxygen species (ROS), which are associated with diseased condition development, such as tumors. This study presents the synthesis, incorporation, and application of a diiodo-BODIPY based photosensitizer, based on a non-covalent functionalization of carbon nano-onions (CNOs). In vitro assays demonstrate that HeLa cells internalize the diiodo-BODIPY molecules, and their CNOs nanohybrids. Upon cell internalization and light exposure, the pyrene-diiodo-BODIPY molecules induce an increase of the ROS level of HeLa cell…
TRAIL acts synergistically with iron oxide nanocluster-mediated magneto- and photothermia
2019
International audience; Targeting TRAIL (Tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand) receptors for cancer therapy remains challenging due to tumor cell resistance and poor preparations of TRAIL or its derivatives. Herein, to optimize its therapeutic use, TRAIL was grafted onto iron oxide nanoclusters (NCs) with the aim of increasing its pro-apoptotic potential through nanoparticle-mediated magnetic hyperthermia (MHT) or photothermia (PT). Methods: The nanovector, NC@TRAIL, was characterized in terms of size, grafting efficiency, and potential for MHT and PT. The therapeutic function was assessed on a TRAIL-resistant breast cancer cell line, MDA-MB-231, wild type (WT) or T…
Physical and Quality of Life Changes in Elderly Patients after Laparoscopic Surgery for Colorectal Cancer—A Prospective Cohort Study
2022
Background—The incidence of colorectal cancer is increasing among elderly people, where postoperative complications are frequent. Methods—We evaluated postoperative physical and quality of life changes in elderly patients undergoing laparoscopic surgery for colorectal cancer. A prospective cohort study was performed in 31 colorectal cancer patients ≥60 years who were scheduled for laparoscopic surgery due to colorectal cancer. Outcomes were measured one month preoperative (T1), three days postoperative (T2) and one month postoperative (T3). Results—The largest early postoperative (from T1 to T2) declines were observed for isometric knee extension strength (33.1%), 30 s …
Skuteczność doświadczenia liturgii
2020
Artykuł podejmuje zagadnienie skutecznego oddziaływania liturgii na jej uczestników i w ogóle stykających się z nią, uwypuklając jej ewangelizacyjne i formacyjne skutki. W szczególny sposób uwzględniono w nim znaczenie piękna liturgicznych celebracji, jak również kwestie związane z tzw. participatio actuosa. Zasadniczą bazę źródłową artykułu stanowią publikacje takich wybitnych teologów, jak: J. Ratzinger, R. Guardini oraz J.A. Jungmann. Analiza ich refleksji zachęca do nowego odkrywania istotnej roli liturgii, zwłaszcza liturgii niedzielnej Mszy św. − jako najważniejszego wydarzenia w religijnym życiu chrześcijanina na przestrzeni tygodnia, a także do ukazywania wartości doświadczenia litu…
Bar à vin dans un établissement de santé : un dispositif innovant d’atelier thérapeutique
2016
International audience; Comme le souligne justement Antoine Hennion dans son plaidoyer pour une approche pragmatique du soin et de l’accompagnement (2006), la maladie est avant tout une rupture modifiant profondément le socle identitaire et l’altérité du malade. La rupture touche alors l’intégrité et la vie sociale. Cette double rupture a des impacts sur la vie dans son ensemble et en redessine les contours. Dans le cadre du projet de recherche ALIMS (Alimentation et Lutte contre les Inégalités en Milieu de Santé), une série d’entretiens a été conduite avec des patients hospitalisés, atteints d’un cancer et en cure de chimiothérapie. L’analyse des premières données montre toute la complexit…