Search results for "Cance"
showing 10 items of 12092 documents
The Prognostic Characteristics and Recurrence Patterns of High Grade Endometrioid Endometrial Cancer: A Large Retrospective Analysis of a Tertiary Ce…
2023
High grade endometrioid endometrial cancer (HGEEC) is a heterogeneous group of tumors with unclear prognostic features. The aim of the present study is to evaluate the independent risk factors for recurrence and mortality and to describe the recurrence patterns of HGEEC. Ninety-six consecutive cases of HGEEC treated with primary surgery in a single Tertiary Center were retrospectively reviewed. Clinicopathological and treatment details were recorded, and all patients were closely followed up. Disease-free, overall and cancer-specific survival rates were 83.8%, 77.8% and 83.6%, respectively. Cervical stromal involvement was independently related to recurrence (HR = 25.67; 95%CI 2.95–223.30; …
D.M. 155/07: Registro degli esposti agli agenti cancerogeni
2008
Four-dimensional representation of scattering amplitudes and physical observables through the application of the Loop-Tree Duality theorem
2019
Las últimas dos décadas han sido testigo de un tremendo progreso en la física teórica de alta precisión. Muchos avances han sido hechos, en particular, en la evaluación de diagramas multi-loop, pero el principal desafío yace en el tratamiento de las divergencias IR a través de eficientes esquemas de substracción. Con la complejidad del procedimiento incrementándose exponencialmente con el número de escalas, se ha hecho necesario tratar la cuestión desde un ángulo diferente, invocando así al desarrollo de nuevas técnicas. La Dualidad Lazo-Árbol (LTD, por sus siglas en inglés) provee de un nuevo marco para el cómputo de amplitudes con loops. A través de la modificación de la prescripción está…
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group…
2021
Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received three cycles with bortezomib (btz), cyclophosphamide, and dexamethasone (dex
El papel moderador de la inteligencia competitiva en la orientación ambidiestra de las Pymes
2017
Resumen: En los últimos años se ha generado conocimiento e investigación sobre inteligencia competitiva en organizaciones de gran tamaño pero poco se sabe del uso de ésta en empresas de pequeño tamaño y cuál es su contribución a la generación de ambidestreza organizativa en empresas frente a entornos turbulentos y mercados en declive. Basándose en la evidencia empírica en la industria del mueble en la Comunidad Valenciana en España y utilizando el Sistema de Inteligencia Competitiva Sectorial (SICM) desarrollado por el Instituto Tecnológico AIDIMA, desde 1998, el presente documento propone un trabajo de tesis de investigación orientado a construir analizar la relación entre el uso de la int…
Inhibition of Hsp60 expression by doxorubicin and replicative senescence instauration in mucoepidermoid carcinoma cells
2014
Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker
2022
Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…
Characterization of the metabolic profile and identification of potential therapeutic targets in advanced prostate cancer patients
2023
INTRODUCCIÓN El cáncer de próstata (CaP) representa el segundo tumor en incidencia en hombres y es la quinta causa de muerte por cáncer a nivel global. El CaP es un tumor hormono-dependiente, que requiere de la activación del receptor de andrógenos (AR) para su proliferación. Clínicamente, se caracteriza por una gran variabilidad en su evolución, progresando desde una condición indolente hasta un fenotipo agresivo que puede diseminarse y metastatizar a los nodos linfáticos y huesos. Actualmente, el diagnóstico temprano del CaP se realiza mediante la determinación sérica del antígeno prostático específico (PSA) y el examen rectal digital (DRE). Si estas pruebas dan resultados anómalos y hay …
Low levels of both xanthine dehydrogenase and of cellular retinol binding protein are responsible for retinoic acid deficiency in malignant human mam…
2009
The seeming impairment of retinoid metabolism in human breast tumor cells has been attributed to the lower expression of cellular retinol binding proteins (CRBPs), of alcohol/retinol dehydrogenases, or aldehyde/retinaldehyde dehydrogenases. In a previous study we indicated that xanthine dehydrogenase (XDH) is able to oxidize actively both all-trans-retinol (t-ROL) bound to the CRBP (holo-CRBP) and all-trans-retinaldehyde (t-RAL) to all-trans-retinoic acid (t-RA) in human mammary epithelial cells (HMEC). Since both XDH and CRBP are required for the biosynthesis of t-RA, we have inspected their bioavailability in both estrogen-responsive and nonresponsive human mammary epithelial cancer cells…