Search results for "Cape"

Risk of Invasive Lupinus polyphyllus Seed Survival in Biomass Treatment Processes

2021

Invasive plant species threaten native species and habitats causing ecologic, economic and social burden. When creating climate friendly solutions by utilizing plant biomasses in biogas and fertilizer production, safety should be ensured concerning the use of residues. This study concentrates on the treatment of biomasses containing invasive plant material by tunnel and windrow composting, and by farm-scale and laboratory-scale anaerobic digestion (AD) in mesophilic conditions. Germination of the nationally settled and harmful invasive species Lupinus polyphyllus Lindl. was investigated after these processes. In addition, the role of the conditions found in the processes that destroyed seed…

Reintroduced northern bald ibises from Spain reach Morocco

2017

5G IoT system for real-time psycho-acoustic soundscape monitoring in smart cities

2020

In Next-Generation Technologies, the monitoring of environmental noise nuisance in the Smart City should be as efficient as possible. 5G IoT systems offer a great opportunity to offload the node calculation, as they provide a number of new concepts for dynamic computing that previous technologies did not offer. In this case, a complete 5G IoT system for psycho-acoustic monitoring has been implemented using different options to offload the calculation of the parameters to different parts of the system. This offloading has been implemented by directly computing the metrics in the node (as a Raspberry Pi), and in a ESP32 device (FiPy) and by sampling the audio and sending it to the EDGE in the…

Soil genetic erosion: New conceptual developments in soil security

2019

In the last decades, in some Mediterranean areas, pedodiversity decreased mainly due to pedotechnique application in large-scale farming that transformed original soils into Anthrosols. Supporting the consideration that soils can be considered as living systems, the original concept of 'soil genetic erosion' is re-proposed. Data, extrapolated and modeled from a Soil Information System in a study case representative of a Mediterranean landscape, predicted that most of the soil types would disappear in few years leading to a decrease of the soil diversity and originating soil genetic erosion. This circumstance is intentionally here told in form of a story where the fairy tale characters are s…

Soil conservation and sustainable development goals(SDGs) achievement in Europe and central Asia: Which role for the European soil partnership?

2021

Abstract Voluntary soil protection measures are not sufficient to achieve sustainable soil management at a global scale. Additionally, binding soil protection legislation at national and international levels has also proved to be insufficient for the effective protection of this non-renewable natural resource. In 2012, the FAO Members established the Global Soil Partnership (GSP) with the mission to facilitate and contribute exchange of knowledge and technologies related to soils, and develop dialogue and raise awareness for the need to establish a binding global agreement for sustainable soil management. Moreover, region-specific aspects of implementation are considered and strengthened th…

Effect of Host Species on Topography of the Fitness Landscape for a Plant RNA Virus

2016

[EN] Adaptive fitness landscapes are a fundamental concept in evolutionary biology that relate the genotype of individuals with their fitness. At the end, the evolutionary fate of evolving populations depends on the topography of the landscape, that is, the number of accessible mutational pathways and of possible fitness peaks (i.e, adaptive solutions). For long time, fitness landscapes were only theoretical constructions due to a lack of precise information on the mapping between genotypes and phenotypes. In recent years, however, efforts have been devoted to characterize the properties of empirical fitness landscapes for individual proteins or for microbes adapting to artificial environme…

FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric …

2021

Claudin 18.2 (CLDN18.2) is contained within normal gastric mucosa epithelial tight junctions; upon malignant transformation, CLDN18.2 epitopes become exposed. Zolbetuximab, a chimeric monoclonal antibody, mediates specific killing of CLDN18.2-positive cells through immune effector mechanisms.The FAST study enrolled advanced gastric/gastro-oesophageal junction and oesophageal adenocarcinoma patients (aged ≥18 years) with moderate-to-strong CLDN18.2 expression in ≥40% tumour cells. Patients received first-line epirubicin + oxaliplatin + capecitabine (EOX, arm 1, n = 84) every 3 weeks (Q3W), or zolbetuximab + EOX (loading dose, 800 mg/mIn the overall population, both PFS [hazard ratio (HR) = 0…

The Bioactive Compounds and Antioxidant Activity of Food Products of Rhizophora stylosa Fruit (Coffee and Tea Mangrove)

2018

The objective of this study is to investigate the bioactive compounds and antioxidant activity of coffee and tea mangrove (locally known in Indonesia) produced from the fruit of Rhizophora stylosa. Furthermore, three raw materials of coffee mangrove were also investigated to clarify their potencies. The crude extracts of five samples were subjected to antioxidant assay using DPPH. The results show that the extract of tea mangrove has the strongest activity; then, it was successfully fractionated using different polarity of solvents and yielded acetone and methanol fractions that had high antioxidant activity. The acetone fraction was purified and gave fractions A1, A2, A3, A4, A5, and A6, b…

Checkpoint Inhibition in Non-Hodgkin's Lymphoma.

2017

As patients continue to die from malignant lymphoma, novel treatment options continue to be warranted. To successfully grow and spread, tumor cells need to escape the immune system; therefore, the augmentation or restoration of immune effectors against the malignant cell could be of great value, as shown, e.g., for allogeneic transplantation. A deepened understanding of the regulation of activation and inhibition of the T cell-based effector mechanisms has led to the development of drugs that are able to modify specific checkpoints of this system and thereby raise an immune response against tumor cells. With dramatic responses observed in Hodgkin's disease (HD), interest has risen to explor…

Common extracellular matrix regulation of myeloid cell activity in the bone marrow and tumor microenvironments

2017

The complex interaction between cells undergoing transformation and the various stromal and immunological cell components of the tumor microenvironment (TME) crucially influences cancer progression and diversification, as well as endowing clinical and prognostic significance. The immunosuppression characterizing the TME depends on the recruitment and activation of different cell types including regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages. Less considered is the non-cellular component of the TME. Here, we focus on the extracellular matrix (ECM) regulatory activities that, within the TME, actively contribute to many aspects of tumor progression, acti…